Understanding genetic causes of childhood lung diseases
Official title: INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE
Funded at Boston Children's Hospital · NIH-10981781 · Data updated 2026-11-12
This study is looking at the genes that might cause lung diseases in babies and young kids, hoping to find specific changes in their DNA that could help doctors give better treatments tailored just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 26, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $844,386 |
| NIH project number | 1R01HL170151-01A1 |
| Project ID | NIH-10981781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with interstitial lung diseases, particularly those under the age of 11.
✕Less likely to help
Patients with lung diseases not classified as interstitial or diffuse, or those over the age of 21, may not benefit from this research.
What this research studies
This research investigates the genetic factors behind Children's Interstitial and Diffuse Lung Diseases (chILD), which affect infants and young children. By using whole-exome sequencing and gene expression profiling of lung biopsy samples, the team aims to identify specific genetic mutations that contribute to these diseases. The goal is to create a molecular classifier that can categorize patients based on their genetic profiles, potentially leading to more targeted and effective treatments. This project seeks to improve the understanding of chILD and enhance the care provided to affected children.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatments for children suffering from chILD.
How similar studies have gone: Previous research has shown promise in identifying genetic causes of similar lung diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Raby, Benjamin Alexander — Boston Children's Hospital
- Study coordinator: Raby, Benjamin Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.