Finding genes that cause interstitial lung disease in children
INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11177025
Researchers will look at genes and lung tissue from children with interstitial lung disease to group similar cases and guide better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11177025 on ClinicalTrials.gov |
What this research studies
This project uses two approaches: genetic sequencing of children seen in specialized chILD clinics and detailed gene activity mapping of lung biopsy samples. The team will profile about 300 biopsy samples to identify groups of patients with similar molecular signatures. They will build a molecular classifier using 50 samples with clear genetic diagnoses, validate it on another 50 samples, and then apply it to the remaining 200 samples. The aim is to find shared biological causes that could point to more targeted care for children with chILD.
Who could benefit from this research
Good fit: Children (infants through adolescence) diagnosed with or suspected to have childhood interstitial and diffuse lung disease who have available clinical data and donated or could donate blood or lung biopsy samples would be the ideal candidates.
Not a fit: People without chILD or those who cannot or will not provide genetic or biopsy samples are unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, the work could lead to clearer genetic diagnoses for many children with chILD and help direct more precise, biologically based treatments.
How similar studies have performed: Earlier work by this team has already provided genetic diagnoses in about 20% of cases and discovered several new candidate genes, so this project builds on promising preliminary results.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RABY, BENJAMIN ALEXANDER — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: RABY, BENJAMIN ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.