Condition

Pulmonary Fibrosis clinical trials and research

• 22Clinical trials
• 174NIH research projects
• 11Countries

Newest Pulmonary Fibrosis clinical trials

All recruiting trials (22)

• AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT

  This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT07761377

• Advanced imaging to see how immunosuppression affects lung fibrosis activity

  This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07572383

• 68Ga-NI-FAPI-04 PET/CT imaging to detect fibroblast activation in cancer, fibrotic, and heart diseases

  This test will see if an injected PET tracer called 68Ga-NI-FAPI-04 can better show fibroblast activation in people with tumors, pulmonary fibrosis, certain autoimmune vascular diseases, hypertrophic cardiomyopathy, or other cardiovascular conditions.

  Recruiting Phase 1/2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07464132

• Home monitoring for patients with pulmonary fibrosis

  This study tests if using home monitoring and video calls can help people with pulmonary fibrosis manage their condition as well as or better than regular clinic visits.

  Recruiting at 11 sites Erasmus Medical Center · Amsterdam and 10 other locations · NCT06883448

• Understanding genetic and environmental factors in pulmonary fibrosis

  This study looks at how genes and environmental factors affect pulmonary fibrosis to help understand the disease better for people who have it.

  Recruiting Royal College of Surgeons, Ireland · Dublin · NCT06702228

• Identifying biomarkers for progressive pulmonary fibrosis in lung disease patients

  This study is trying to find early signs that can help predict if adults with certain lung diseases will develop progressive pulmonary fibrosis over the next five years.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06644144

• Routine versus on-demand ECMO during lung transplant

  This trial tests whether using ECMO routinely during lung transplant or only when needed leads to fewer complications for people having a lung transplant.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Edmonton, Alberta and 3 other locations · NCT06615492

• Advanced Imaging for Pulmonary Fibrosis

  This study is testing a new imaging technique to see if it can help doctors better understand and treat people with pulmonary fibrosis.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06532071

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Using cryobiopsy to diagnose progressive pulmonary fibrosis

  This study is testing a new lung biopsy method called cryobiopsy to see if it can diagnose progressive pulmonary fibrosis better and safer than the traditional method.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT06251687

• Evaluating FAP as a biomarker for fibrotic lung diseases

  This study is testing if a protein called FAP can help doctors understand and track fibrotic lung diseases like idiopathic pulmonary fibrosis by looking at its levels in different samples and using special scans before and after treatments.

  Recruiting Phase 2 Erasme University Hospital · Brussels · NCT06189820

• Predicting worsening of pulmonary fibrosis using AI from CT scans

  This study is testing if using AI to analyze CT scans can help predict which patients with pulmonary fibrosis are likely to get worse over time.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06162884

• Digital self-management package for people with interstitial lung disease

  This study is testing a new smartphone app designed to help people with interstitial lung disease manage their health better and feel improved overall compared to standard care.

  Recruiting at 4 sites University of Sydney · Sydney, New South Wales and 3 other locations · NCT06122233

• Biobank for interstitial lung diseases

  This study is setting up a collection of health information and samples from patients with interstitial lung diseases to help researchers learn more about the condition and find better treatments.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05392881

• Registry for individuals affected by pulmonary fibrosis

  This study invites people with pulmonary fibrosis, along with their caregivers and family members, to share their experiences through online surveys to help researchers understand the condition better and possibly reach out for future studies.

  Recruiting Pulmonary Fibrosis Foundation · Chicago, Illinois · NCT05382572

• Comparing two imaging methods for diagnosing pulmonary fibrosis

  This study is testing if a new imaging method called 68Ga-FAPI PET/CT can better diagnose and monitor treatment for people with pulmonary fibrosis compared to the standard method, 18F-FDG PET/CT.

  Recruiting Phase 1 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05121779

• Non-drug therapy for controlling cough in patients with lung disease

  This study is testing a new non-drug therapy to help adults with interstitial lung disease and a long-lasting cough feel better when combined with pulmonary rehabilitation.

  Recruiting at 2 sites West Park Healthcare Centre · Hamilton, Ontario and 1 other locations · NCT04767074

• Evaluating a new imaging probe for lung conditions

  This study is testing a new imaging tool to see if it can safely help detect lung problems like fibrosis and cancer in healthy people and patients.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT03535545

• European database and biobank for childhood interstitial lung diseases

  This study is creating a database and biobank to collect information and samples from children with interstitial lung diseases across Europe to improve their treatment and understanding of these conditions.

  Recruiting at 3 sites Ludwig-Maximilians - University of Munich · Hanover, Lower Saxony and 2 other locations · NCT02852928

• Using lung tissues to study pulmonary fibrosis

  This study looks at lung tissues from patients with pulmonary fibrosis to see what changes happen in the lungs and how it might help find new treatments for the disease.

  Recruiting University of Chicago · Chicago, Illinois · NCT00515567

• Exploring genetic traits in pulmonary fibrosis

  This study is trying to find out if certain genes affect how idiopathic pulmonary fibrosis develops and how it impacts lung healing in patients.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT00258570

• Exploring genetic factors in lung disease development

  This study is trying to find out how certain genes might play a role in lung diseases like cystic fibrosis and asthma by looking at lung cells from both patients and healthy people.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT00001532

NIH-funded research (newest 40 of 174)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Molecular clues to progressive lung scarring

  Researchers are studying how lung tissue becomes progressively scarred, focusing on cell signals and receptors that may drive fibrosis in people with lung disease.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11577962

• Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Targets

  This grant explores how rare SFTPC mutations in alveolar cells may drive IPF and seeks new molecular targets to improve treatment.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11575419

• Iron and scar-forming cells in the lungs (IPF)

  Researchers are exploring how iron in the lungs may drive the scarring seen in idiopathic pulmonary fibrosis and whether this could lead to new therapies.

  NIH research Oklahoma State University Stillwater · Stillwater, United States · NIH-11559120

• Repurposing Pyrvinium as an Inhaled Therapy for Idiopathic Pulmonary Fibrosis

  A patient-friendly look at a project trying to use an existing drug, pyrvinium, as an inhaled treatment option for idiopathic pulmonary fibrosis (IPF).

  NIH research Oleolive, INC. · Shreveport, United States · NIH-11550918

• Screening new compounds to reverse gene signatures in IPF lungs

  A researcher hopes to find compounds that reverse harmful gene changes in the lungs of people with idiopathic pulmonary fibrosis (IPF).

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11494256

• Role of lactate transporters in lung scarring

  Aims to see if blocking lactate transporters can slow or stop scar-forming cells from thickening the lungs in people with fibrotic lung disease.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11477025

• Formyl peptide receptor links inflammation to lung disease in rheumatoid arthritis

  This grant looks at how a receptor on immune cells may drive lung inflammation in people with rheumatoid arthritis and related conditions.

  NIH research University of Washington · Seattle, United States · NIH-11451453

• p53 acetylation and alveolar stem cell aging in progressive lung fibrosis

  Scientists are studying how changes to a cancer-related protein, p53, affect aging lung cells and contribute to a scary lung disease called IPF.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11449164

• Targeted nanoparticle therapy for lung fibrosis

  A researcher team is testing inhaled nanoparticles that deliver medicine directly to the lungs to slow or stop scarring in people with pulmonary fibrosis.

  NIH research Texas Engineering Experiment Station · College Station, United States · NIH-11448075

• Understanding how tobacco smoke changes lung fibroblasts in pulmonary fibrosis

  A study exploring how cigarette smoke affects lung cells to drive fibrosis, with a focus on a protein called PRMT5 and potential ways to slow disease progression.

  NIH research University of California at Davis · Davis, United States · NIH-11443942

• Lung cell transplantation for drug-induced lung scarring in cancer patients

  A new approach tests transplanting lung cells to repair scarring caused by cancer drugs in people with cancer.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425968

• Unraveling IPF subtypes to guide prognosis and therapy

  This grant aims to identify different IPF subtypes in the lung to improve how we predict outcomes and tailor treatments for people with IPF.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11411171

• Understanding how early changes in lungs lead to progressive fibrotic disease

  This grant studies the cells and genes involved in starting and advancing pulmonary fibrosis to uncover why some people progress to severe disease.

  NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11406083

• Thromboxane Receptor: a new target to reduce radiation lung scarring

  Aims to see if blocking a specific receptor in the lungs can reduce scarring after chest radiation in patients.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11398095

• Proteomic clues for early and late lung fibrosis

  Researchers are studying protein markers in the lungs to understand how pulmonary fibrosis starts and progresses, with the aim of helping people at risk for the disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11397762

• Epac1 and lung scarring in idiopathic pulmonary fibrosis

  Looks at whether blocking a protein called Epac1 can reduce lung scarring in people with idiopathic pulmonary fibrosis.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11397242

• Support-T: a mobile tool to help people with progressive pulmonary fibrosis and their caregivers get palliative care and planning

  A mobile app called SUPPORT-T helps people with progressive pulmonary fibrosis and their caregivers access palliative care and plan for the future.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11396964

• Alveolar immune and lung cell lipid metabolism in fibrosis

  A physician-scientist at UCLA is pursuing a five-year plan to understand how lipid metabolism in lung cells contributes to idiopathic pulmonary fibrosis and to build translational research using patient samples.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11393697

• Defining how early pulmonary fibrosis develops at the molecular level

  Researchers are studying early stages of pulmonary fibrosis at the molecule-by-molecule level to understand how the disease starts and progresses in people.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11392457

• Functional genomic insights into epithelial dysfunction in pulmonary fibrosis

  Researchers are studying people at risk for familial pulmonary fibrosis to understand how early cellular changes in the lungs develop into full disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11392456

• Understanding and preventing early lung fibrosis in at-risk people

  A program to uncover the early clues and biology that lead to lung fibrosis and to develop ways to prevent it before symptoms start.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11392446

• Cell competition in lung fibrosis and ARDS

  A Mayo Clinic team is studying how lung cells compete and repair after injury in people with severe lung diseases like IPF, ARDS, and after viral infections, to find ways to improve recovery.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11392294

• Targeting an amino acid transporter to fight lung scarring

  A researcher is studying whether blocking a specific transporter (SLC7A5) in lung cells can slow or stop the scarring process seen in idiopathic pulmonary fibrosis.

  NIH research Washington University · Saint Louis, United States · NIH-11385344

• How mechanical forces affect lung scarring and metabolism in IPF

  A researcher at a major university is studying how the stiffness of lung tissue and specific cellular sensors may drive metabolism changes that worsen idiopathic pulmonary fibrosis in patients.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11382219

• Novel antibody therapy to treat idiopathic pulmonary fibrosis

  A small business gig is developing a targeted antibody drug (VSR-H5) to treat idiopathic pulmonary fibrosis in patients, aiming for better safety and effectiveness than current medicines.

  NIH research Vasarya Therapeutics, INC. · Camden, United States · NIH-11382077

• IgA antibodies to oxidation-related targets in lung fibrosis

  This NIH grant explores how certain IgA antibodies against damaged lung components relate to idiopathic pulmonary fibrosis and what that means for future therapies.

  NIH research University of Virginia · Charlottesville, United States · NIH-11381817

• Predicting Post-Covid Lung Scarring with Easy-to-Understand Deep Learning and Key Biomarkers

  Aims to use explainable artificial intelligence and biomarker data from multiple hospitals to predict which patients will develop long-term lung scarring after COVID-19.

  NIH research Northwestern University · Chicago, United States · NIH-11380916

• Advanced Imaging to Predict Progressive Lung Fibrosis in ILD

  This grant tests imaging tools to identify people with non-IPF interstitial lung disease who will develop progressive fibrotic lung disease, so doctors can tailor treatment early.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11380706

• Collagen oxidation and cell signals in aging-related lung fibrosis

  A patient-facing study exploring how aging-related changes in collagen and cell signaling contribute to scarring in the lungs of people with a condition like idiopathic pulmonary fibrosis (IPF).

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11378412

• Desmoplakin’s Role in Lung Fibrosis in HD AT2 Cells

  A study in adult human lung cells aims to understand how a genetic change in desmoplakin may contribute to lung fibrosis.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11377594

• Targeting WNT7A Signaling to Improve Lung Repair in Pulmonary Fibrosis

  Aims to test whether blocking WNT7A signaling can help the lungs repair themselves and reduce scarring in people with a serious lung disease.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11377523

• Understanding how MUC5B gene control affects lung scarring (IPF)

  This grant explores how changes in gene regulation lead to high MUC5B levels and lung scarring in IPF, with potential implications for patients living with this disease.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11377009

• Using targeted PET imaging and new treatment to predict and treat radiation-induced lung scarring

  Aims to use a special PET imaging button to see a specific protein (αvβ6) in the lungs after radiation and test a new drug to prevent or treat the scarring called RIPF.

  NIH research Washington University · Saint Louis, United States · NIH-11376191

• Intracellular Collagen Sensing in Lung Fibrosis

  Researchers are studying how lung cells detect and clear collagen to find new ways to reverse fibrosis in IPF.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11375427

• Optical imaging biomarker to predict lung disease outcomes in IPF

  A new imaging test using tiny endobronchial optics could help predict how IPF will progress and who might need a transplant.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11374250

• Understanding why some lung repairs go wrong in pulmonary fibrosis

  This NIH grant looks at why the lungs sometimes repair damage poorly after injury, with a focus on people who have or are at risk for pulmonary fibrosis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11367540

• Repurposing Vonoprazan as an inhaled therapy for IPF

  A high-profile NIH grant is testing whether an existing drug, vonoprazan, can be inhaled to slow or reverse lung fibrosis in people with idiopathic pulmonary fibrosis (IPF).

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11366024

• Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Treatments

  A study focused on a specific lung cell defect linked to a common scarring lung disease (IPF) to uncover new targets for therapy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11365117

• Proteomic profile of IPF progression to help tailor treatments

  A study will look for blood protein patterns that predict how IPF lung disease will progress in patients.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11365030

• Understanding how blood vessel signals affect post-flu and post-coronavirus lung scarring

  This NIH grant looks at how a specific blood vessel signal (S1PR1) in the lungs might prevent scarring after severe viral lung infections like flu or COVID-19.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11364083

Related topics

Quick answers

How many Pulmonary Fibrosis clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (9 trials), China (4 trials), Canada (2 trials), Netherlands (2 trials), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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