Condition

Progressive Pulmonary Fibrosis clinical trials and research

• 12Clinical trials
• 9NIH research projects
• 1New in 30 days
• 25Countries

Newest Progressive Pulmonary Fibrosis clinical trials

All recruiting trials (12)

• Nerandomilast in IPF and Progressive Fibrosis: Real-World Data

  This study tests whether nerandomilast helps slow lung function decline in adults with IPF or progressive fibrotic lung disease in routine clinical care.

  Recruiting at 4 sites Tel Aviv Medical Center · Ashkelon and 3 other locations · NCT07919015

• Inspiratory Flow Rate Capability in Pulmonary Fibrosis Patients

  This observational study tests how fast patients with IPF or PPF can inhale through dry powder inhalers with different resistances.

  Recruiting Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT07820254

• Treprostinil Palmitil Inhalation Powder for Progressive Pulmonary Fibrosis

  A 52-week study will test whether once-daily Treprostinil Palmitil Inhalation Powder helps lung function in adults with progressive pulmonary fibrosis compared to placebo.

  Recruiting Phase 3 Insmed Incorporated · DuBois, Pennsylvania · NCT07805785

• Finger vs. Earlobe Pulse Oximetry During a 6-Minute Walk Test in ILD

  This study tests whether finger or earlobe pulse oximetry gives the same oxygen saturation readings during a 6-minute walk in people with interstitial lung disease.

  Recruiting Hospital de Granollers · Granollers, Spain · NCT07723872

• Progressive Pulmonary Fibrosis in China: A Nationwide Registry

  This study will follow 600 Chinese adults with progressive pulmonary fibrosis to see how the disease changes over 1–2 years using real-world data.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07683728

• Quercetin supplementation for people with fibrotic interstitial lung disease

  This research will try whether taking 500 mg/day of quercetin in two 12-week cycles can change telomere length, reduce signs of cellular aging, and affect lung function in people with IPF and other fibrotic interstitial lung diseases.

  Recruiting University of Crete · Heraklion, Crete · NCT07466420

• Measuring body fat and thigh muscle in people with pulmonary fibrosis starting anti-fibrotic drugs

  This project will test whether quick bioelectrical impedance measurements and thigh muscle ultrasound can detect changes in body fat and muscle in adults with IPF or progressive pulmonary fibrosis who are starting anti-fibrotic medications.

  Recruiting Royal Brompton & Harefield NHS Foundation Trust · London · NCT07332117

• SUPPORT-T palliative program for people with progressive pulmonary fibrosis and their caregivers

  This pilot tests a 9-week digital palliative care program plus quarterly virtual support groups to see if it helps adults with progressive pulmonary fibrosis and their caregivers.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07269262

• Extension of inhaled antifibrotic treatment with AP01 for pulmonary fibrosis

  This open-label extension lets people with progressive pulmonary fibrosis or IPF who finished a prior Avalyn inhaled-drug study continue taking inhaled pirfenidone (AP01) twice daily to see if they can tolerate and stay on treatment.

  Recruiting at 88 sites Phase 2 Avalyn Pharma Inc. · Birmingham, Alabama and 91 other locations · NCT06951217

• Observational study on progressive pulmonary fibrosis and its classification

  This study is trying to better understand and classify progressive pulmonary fibrosis in people with certain lung diseases by following them over two years and collecting their health information and blood samples.

  Recruiting at 9 sites University of Massachusetts, Worcester · Aurora, Colorado and 23 other locations · NCT06855329

• Evaluating inhaled treprostinil for progressive pulmonary fibrosis

  This study is testing if inhaled treprostinil can help people with progressive pulmonary fibrosis breathe better and live longer compared to a placebo.

  Recruiting at 165 sites Phase 3 United Therapeutics · Birmingham, Alabama and 164 other locations · NCT05943535

• Registry for individuals affected by pulmonary fibrosis

  This study invites people with pulmonary fibrosis, along with their caregivers and family members, to share their experiences through online surveys to help researchers understand the condition better and possibly reach out for future studies.

  Recruiting Pulmonary Fibrosis Foundation · Chicago, Illinois · NCT05382572

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Molecular clues to progressive lung scarring

  Researchers are studying how lung tissue becomes progressively scarred, focusing on cell signals and receptors that may drive fibrosis in people with lung disease.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11577962

• p53 acetylation and alveolar stem cell aging in progressive lung fibrosis

  Scientists are studying how changes to a cancer-related protein, p53, affect aging lung cells and contribute to a scary lung disease called IPF.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11449164

• Support-T: a mobile tool to help people with progressive pulmonary fibrosis and their caregivers get palliative care and planning

  A mobile app called SUPPORT-T helps people with progressive pulmonary fibrosis and their caregivers access palliative care and plan for the future.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11396964

• Defining how early pulmonary fibrosis develops at the molecular level

  Researchers are studying early stages of pulmonary fibrosis at the molecule-by-molecule level to understand how the disease starts and progresses in people.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11392457

• How lung cells change in early and worsening pulmonary fibrosis

  Researchers will map how specific lung cells and their local neighborhoods change over time in people at risk for or with pulmonary fibrosis using advanced tissue-based gene mapping.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11193835

• The effects of air pollution on progressive pulmonary fibrosis

  This study is looking at how air pollution, especially tiny particles and nitrogen dioxide, might lead to a serious lung condition called progressive pulmonary fibrosis, particularly in people living in areas that are more vulnerable to pollution.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11053723

• Understanding how lung fibrosis progresses at a molecular level

  This study is looking at how a substance called hyaluronan affects lung inflammation and healing in people with progressive pulmonary fibrosis, with the hope of finding new ways to help improve lung health.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11045656

• New oral medications for treating progressive lung scarring

  This study is testing a new oral medication for people with idiopathic pulmonary fibrosis (IPF) that aims to slow down or even reverse lung damage by targeting cells that cause scarring, offering a safer and more effective option than current treatments.

  NIH research Novomedix, INC. · San Diego, United States · NIH-11008167

• Understanding the early stages and progression of pulmonary fibrosis

  This study is looking at how pulmonary fibrosis develops by examining tissue samples from people at risk for the condition, with the goal of finding new ways to diagnose and treat it better.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10846188

Related topics

Quick answers

How many Progressive Pulmonary Fibrosis clinical trials are recruiting right now?

12, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (6 trials), Spain (3 trials), Australia (3 trials), Canada (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →