Understanding how certain cells contribute to lung disease in systemic sclerosis
Uncovering the genomic regulatory network of myofibroblast differentiation in systemic sclerosis-associated interstitial lung disease
['FUNDING_CAREER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10910899
This study is looking at how certain genes help turn cells into myofibroblasts, which are important in lung problems for people with systemic sclerosis, to better understand how to treat this condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10910899 on ClinicalTrials.gov |
What this research studies
This research investigates the gene regulatory networks that control the differentiation of myofibroblasts, which are crucial cells involved in fibrosis, particularly in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study aims to uncover the molecular mechanisms that lead to the formation of these cells, as they play a significant role in the progression of lung disease. By utilizing advanced techniques in computational and molecular biology, the research seeks to develop a deeper understanding of these processes, which could inform future treatment strategies. Patients may benefit from insights gained that could lead to targeted therapies for this challenging condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic sclerosis and associated interstitial lung disease.
Not a fit: Patients with other forms of lung disease not related to systemic sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target myofibroblasts, potentially improving outcomes for patients with systemic sclerosis-associated lung disease.
How similar studies have performed: While the specific approach of targeting myofibroblast differentiation in SSc-ILD is novel, similar research in other fibrotic diseases has shown promising results.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VALENZI, ELEANOR — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: VALENZI, ELEANOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome