Genetic Mapping of Childhood Lung Disease to Find Better Treatments
Official title: INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE
Funded at Boston Children's Hospital · NIH-11404895 · Data updated 2026-11-12
A Boston Children’s Hospital team is studying why some kids develop interstitial lung disease by mapping their genes and lung tissue patterns to find more precise, biologically based therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 26, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $730,540 |
| NIH project number | 5R01HL170151-03 |
| Project ID | NIH-11404895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children diagnosed with chILD who have or could have genetic and molecular profiling of lung tissue.
✕Less likely to help
Patients without access to lung tissue samples or whose disease does not align with identified molecular clusters may not benefit directly.
What this research studies
In this project, researchers will analyze genetic data from children with chILD and examine gene activity in lung biopsy samples to identify distinct molecular groups. They will profile about 300 biopsy samples to define patient clusters with similar genetic profiles and create a molecular classifier using a subset of samples, then test it on additional cases. The goal is to connect specific gene differences to lung disease mechanisms so future treatments can target those pathways. This work relies on real patient samples and clinic data, with the aim of guiding more personalized care for affected children.
Why it matters
Potential benefit: If successful, the study could lead to more targeted therapies for childhood lung disease based on a child’s genetic and molecular profile.
How similar studies have gone: Past work has shown that genetic profiling can identify meaningful groups within chILD and related conditions, supporting this approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Raby, Benjamin Alexander — Boston Children's Hospital
- Study coordinator: Raby, Benjamin Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.