High-flow oxygen therapy for patients on long-term oxygen therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the impact of adding high-flow oxygen therapy to standard low-flow oxygen therapy in patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) who are already on long-term oxygen therapy. Conducted in Sweden, the study recruits participants through the Swedish National Registry for Respiratory Failure and compares the outcomes of those receiving high-flow therapy at night against those receiving only standard therapy over a one-year period. The goal is to enhance treatment protocols and improve patient outcomes in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 40 years or older
* Ongoing LTOT: prescribed for at least 15 hours per day; and since at least 28 days as registered in Swedevox
* COPD or ILD as main underlying reason for LTOT
* Oxygen concentrator as stationary oxygen source in the home including night-time
* Body mass index (BMI) \< 35 kg/m2

Exclusion Criteria:

* Current or previous treatment with home HFOT
* Current treatment with home mechanical ventilation
* Current treatment with home CPAP
* Hospitalized during the last 2 weeks
* Current smoking or contact with flames
* Self-reported average use of the LTOT \< 15h per day (24 hours)
* PaCO2 (breathing air at rest) \> 8 kPa
* Strong clinical suspicion of obstructive sleep apnea (OSA) or obesity-related hypoventilation syndrome (OHS) (as judged by the responsible staff)
* Inability to participate in the study procedures (as judged by the staff)
* Not eligible for continuing LTOT due to other reason (as judged by the staff)
* Expected survival less than 3 months (as judged by the staff)

Where it's running

• Research Unit, Blekinge University of Technology
  Karlskrona, Blekinge County, Sweden Recruiting
• Department of Heart, Lung and Clinical Physiology, Örebro University Hospital
  Örebro, Sweden Recruiting

Study contacts

• Principal investigator: Magnus Ekström, MD, PhD — Skane University Hospital
• Study coordinator: Magnus Ekström, MD, PhD
• Email: magnus.ekstrom@med.lu.se
• Phone: 0455731000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.