Clinical trial Recruiting at 1 site Observational Ages 21 and up

Treatment Response in Myositis-Associated RP-ILD in Adults

Official title: Assessment of Treatment Response in Immune-mediated Myositis Associated Rapidly-progressing Interstitial Lung Disease

Run by Singapore General Hospital · NCT07775235 · Data updated 2026-11-12

This study tests how people with myositis and rapidly progressing interstitial lung disease respond to an immunosuppressant treatment approach.

More Interstitial Lung Disease trials

Quick facts

Study typeObservational
Ages21 Years and up
SexAll
Enrollment80 (estimated)
SponsorSingapore General Hospital
Academic / other
Drugs / interventionsrituximab, tofacitinib
Locations1 site (Singapore)
StatusRecruiting
StartedDecember 26, 2024
Main results expectedJuly 1, 2029
Study endsJuly 1, 2029
Registry record updatedAugust 20, 2026
Trial IDNCT07775235 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (21 years or older) diagnosed with myositis-associated rapidly progressive interstitial lung disease.

Probably not a fit

Patients with other forms of ILD not related to myositis or those not experiencing rapid progression may not benefit from the study insights.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study focusing on adults with immune-mediated myositis and rapidly progressive interstitial lung disease. It aims to describe treatment responses to immunosuppressant regimens used in real-world care, including factors that may influence outcomes. The investigation builds on existing knowledge that RP-ILD in anti-MDA5+ dermatomyositis carries high mortality and explores patterns of care and prognosis without random assignment. Data come from patients treated at Singapore General Hospital and related clinical centers. The study acknowledges the lack of randomized trials in this rare condition and seeks to inform future research and clinical practice.

Why it matters

Potential benefit: If successful, the findings could help clinicians tailor immunosuppressive strategies for adults with myositis-associated RP-ILD and identify factors linked to better outcomes.

How similar studies have gone: Previous work in similar conditions has shown varied responses; this observational approach adds real-world data but randomised evidence remains limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age of 21 years or above;
2. Diagnosis of myositis associated rapidly progressive interstitial lung disease

Exclusion Criteria:

1. Age of less than 21 year old;

Where it's running

  • Singapore General Hospital
    Singapore, Singapore
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.