Treatment Response in Myositis-Associated RP-ILD in Adults
Official title: Assessment of Treatment Response in Immune-mediated Myositis Associated Rapidly-progressing Interstitial Lung Disease
Run by Singapore General Hospital · NCT07775235 · Data updated 2026-11-12
This study tests how people with myositis and rapidly progressing interstitial lung disease respond to an immunosuppressant treatment approach.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Singapore General Hospital Academic / other |
| Drugs / interventions | rituximab, tofacitinib |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | December 26, 2024 |
| Main results expected | July 1, 2029 |
| Study ends | July 1, 2029 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07775235 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (21 years or older) diagnosed with myositis-associated rapidly progressive interstitial lung disease.
✕Probably not a fit
Patients with other forms of ILD not related to myositis or those not experiencing rapid progression may not benefit from the study insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study focusing on adults with immune-mediated myositis and rapidly progressive interstitial lung disease. It aims to describe treatment responses to immunosuppressant regimens used in real-world care, including factors that may influence outcomes. The investigation builds on existing knowledge that RP-ILD in anti-MDA5+ dermatomyositis carries high mortality and explores patterns of care and prognosis without random assignment. Data come from patients treated at Singapore General Hospital and related clinical centers. The study acknowledges the lack of randomized trials in this rare condition and seeks to inform future research and clinical practice.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor immunosuppressive strategies for adults with myositis-associated RP-ILD and identify factors linked to better outcomes.
How similar studies have gone: Previous work in similar conditions has shown varied responses; this observational approach adds real-world data but randomised evidence remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age of 21 years or above; 2. Diagnosis of myositis associated rapidly progressive interstitial lung disease Exclusion Criteria: 1. Age of less than 21 year old;
Where it's running
-
Singapore General Hospital
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Mohamad Fadhli Bin Masri, MD PhD
- Email: mohamad.fadhli@mohh.com.sg
- Phone: 6576 2609
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Telitacicept for primary Sjögren’s with interstitial lung disease
This study tests whether Telitacicept helps people with primary Sjögren’s syndrome and interstitial lung disease compared with standard immunosuppressants.
-
Imaging markers for bulbar involvement in inclusion body myositis among IBM and comparison groups
This study tests whether ultrasound and MRI can detect swallowing and bulbar muscle problems in people with inclusion body myositis.
-
Inhaled mosliciguat for pulmonary hypertension in interstitial lung disease (PH-ILD) patients
This study tests inhaled mosliciguat versus placebo in people with PH-ILD to see if it helps with their condition.
-
Treprostinil Palmitil Inhalation Powder for Progressive Pulmonary Fibrosis
A 52-week study will test whether once-daily Treprostinil Palmitil Inhalation Powder helps lung function in adults with progressive pulmonary fibrosis compared to placebo.
-
CR-402 treatment for refractory autoimmune disease
This study tests CRT-402, a CD19-targeted CAR-T therapy, in adults with active, treatment-resistant autoimmune diseases like SLE, systemic sclerosis, and inflammatory myopathy to see if it is safe and capable of helping control disease.
-
AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT
This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.