Exploring how stress in lung cells leads to abnormal healing in lung diseases
Official title: Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung disease
Funded at University of Pennsylvania · NIH-10878717 · Data updated 2026-11-12
This study looks at how stress affects lung cells and might lead to interstitial lung diseases, using mice with certain genetic changes to learn more about what happens when these cells are under stress, which could help find new treatments for patients with lung issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $167,940 |
| NIH project number | 5K08HL150226-05 |
| Project ID | NIH-10878717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with interstitial lung diseases, particularly those with genetic mutations affecting alveolar epithelial cells.
✕Less likely to help
Patients with interstitial lung diseases not related to alveolar epithelial cell dysfunction may not benefit from this research.
What this research studies
This research investigates the role of stress in alveolar epithelial cells, which are crucial for lung function, and how this stress contributes to the development of interstitial lung diseases (ILDs). By using mouse models with specific genetic mutations, the study aims to understand the mechanisms behind cellular stress and its impact on lung injury and repair processes. Patients may benefit from insights gained about the underlying causes of ILDs, potentially leading to new therapeutic strategies. The research focuses on the cellular pathways that manage protein stress and how their dysfunction can lead to severe lung conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from interstitial lung diseases.
How similar studies have gone: Previous research has shown that understanding cellular stress mechanisms can lead to significant advancements in treating similar lung conditions, indicating a promising avenue for this study.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Katzen, Jeremy Binder — University of Pennsylvania
- Study coordinator: Katzen, Jeremy Binder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.