Lung MRI for non-cancer lung disease (early IPF)
Magnetic Resonance Imaging of the Lung: Non-Oncological Applications
This project will try using advanced lung MRI (with bronchoalveolar lavage when safe) to look for imaging and molecular signs in people with early-stage idiopathic pulmonary fibrosis (IPF).
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Pavia, Lombardy) |
| Trial ID | NCT07493187 on ClinicalTrials.gov |
What this trial studies
This is an observational, single-center project using advanced magnetic resonance imaging of the lungs in patients with early-stage IPF. When clinically appropriate and safe, bronchoalveolar lavage samples will be collected to link imaging features with cellular and molecular signatures. The work is motivated by data suggesting IPF shows neoplasm-like molecular behavior, including signaling through receptors such as MET, and aims to find noninvasive imaging correlates of those processes. All procedures are performed at Fondazione IRCCS Policlinico San Matteo di Pavia and no investigational treatments are given.
Who should consider this trial
Good fit: Adults with a clinical and radiological diagnosis of early-stage idiopathic pulmonary fibrosis who can safely undergo MRI and bronchoalveolar lavage are ideal candidates.
Not a fit: People with advanced IPF, or anyone who has contraindications to MRI or bronchoalveolar lavage, likely will not benefit from participation.
Why it matters
Potential benefit: If successful, this approach could provide noninvasive ways to detect and monitor early IPF changes and help guide future targeted therapies.
How similar studies have performed: Advanced lung MRI and molecular profiling in IPF have shown promising preliminary results, but combining MRI with molecular markers like MET signaling is still relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical and radiological diagnosis of early-stage IPF Exclusion Criteria: * Absolute contraindications to bronchoalveolar lavage or magnetic resonance imaging
Where this trial is running
Pavia, Lombardy
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Lombardy, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.