Clinical trial Recruiting at 1 site Observational

Lung MRI for non-cancer lung disease (early IPF)

Official title: Magnetic Resonance Imaging of the Lung: Non-Oncological Applications

Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07493187 · Data updated 2026-11-12

This project will try using advanced lung MRI (with bronchoalveolar lavage when safe) to look for imaging and molecular signs in people with early-stage idiopathic pulmonary fibrosis (IPF).

More Interstitial Lung Disease trials

Quick facts

Study typeObservational
SexAll
Enrollment50 (estimated)
SponsorFondazione IRCCS Policlinico San Matteo di Pavia
Academic / other
Drugs / interventionsradiation
Locations1 site (Pavia, Lombardy)
StatusRecruiting
StartedDecember 28, 2020
Main results expectedApril 28, 2026
Study endsApril 28, 2026
Registry record updatedMarch 25, 2026
Trial IDNCT07493187 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with a clinical and radiological diagnosis of early-stage idiopathic pulmonary fibrosis who can safely undergo MRI and bronchoalveolar lavage are ideal candidates.

Probably not a fit

People with advanced IPF, or anyone who has contraindications to MRI or bronchoalveolar lavage, likely will not benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, single-center project using advanced magnetic resonance imaging of the lungs in patients with early-stage IPF. When clinically appropriate and safe, bronchoalveolar lavage samples will be collected to link imaging features with cellular and molecular signatures. The work is motivated by data suggesting IPF shows neoplasm-like molecular behavior, including signaling through receptors such as MET, and aims to find noninvasive imaging correlates of those processes. All procedures are performed at Fondazione IRCCS Policlinico San Matteo di Pavia and no investigational treatments are given.

Why it matters

Potential benefit: If successful, this approach could provide noninvasive ways to detect and monitor early IPF changes and help guide future targeted therapies.

How similar studies have gone: Advanced lung MRI and molecular profiling in IPF have shown promising preliminary results, but combining MRI with molecular markers like MET signaling is still relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinical and radiological diagnosis of early-stage IPF

Exclusion Criteria:

* Absolute contraindications to bronchoalveolar lavage or magnetic resonance imaging

Where it's running

  • Fondazione IRCCS Policlinico San Matteo di Pavia
    Pavia, Lombardy, Italy
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.