Condition

Glioblastoma clinical trials and research

• 151Clinical trials
• 471NIH research projects
• 3New in 30 days
• 27Countries

Newest Glioblastoma clinical trials

All recruiting trials (newest 150 of 151)

• YN003 injection in glioma patients

  This phase 1 study tests whether YN003 injected IV is safe and tolerable for adults with recurrent or progressive glioma, and to explore how the drug behaves in the body and any early signs of activity.

  Recruiting at 2 sites Phase 1 Beijing Inno Medicine Co., Ltd. · Los Angeles, California and 4 other locations · NCT07929909

• Brain connectome project in adults with brain glioma undergoing surgery

  This registry collects MRI data and clinical information from adults with glioma to see how brain networks relate to surgery and recovery.

  Recruiting Northwell Health · New York, New York · NCT07927595

• Lixumistat window of opportunity in newly diagnosed glioblastoma

  This study tests whether Lixumistat can benefit adults with newly diagnosed glioblastoma who are planned for surgical tumor removal.

  Recruiting Early Phase 1 University of Miami · Miami, Florida · NCT07884344

• Glioblastoma in Réunion: an epidemiological and socio-anthropological look at patients and care

  A large group of adults with diffuse gliomas in Réunion is being studied to understand how biology, culture, and health care pathways affect diagnosis and treatment.

  Recruiting Centre Hospitalier Universitaire de la Réunion · Saint-Pierre · NCT07865195

• Butterfly glioblastoma: test adding 5-ALA PoMA with LIDU ultrasound to standard care

  This early-phase study tests whether adding 5-ALA–mediated activation with LIDU ultrasound is safe and tolerable for adults with newly diagnosed butterfly glioblastoma, before or during standard chemotherapy and radiotherapy.

  Recruiting Phase 1 Alpheus Medical, Inc. · Buffalo, New York · NCT07862647

• Maintenance radiotherapy after standard glioblastoma treatment

  This study tests whether a single 2 Gy maintenance radiotherapy dose after standard treatment is safe and feasible for adults with newly diagnosed glioblastoma.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07831772

• Valproic acid, irinotecan, and simvastatin for recurrent glioma in adults

  This trial tests whether the combination of valproic acid, irinotecan, and simvastatin can stabilize or shrink recurrent glioblastoma or IDH-mutant gliomas in adults.

  Recruiting Phase 2 Inova Health Care Services · Fairfax, Virginia · NCT07831369

• Tear Fluid for Detecting Tumor-Linked Particles in Glioblastoma

  This study tests whether tear fluid can reveal tumor-associated particles in people with glioblastoma, potentially offering a easier way to monitor the cancer.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07775534

• Blood-brain barrier profiling in high-grade glioma with imaging, biomarkers, and tissue analysis

  This study tests how the blood-brain barrier is disrupted in adults with newly diagnosed glioblastoma who are getting surgical removal of the tumor.

  Recruiting Beaumont Hospital · Beaumont · NCT07731555

• Intensified adjuvant therapy for high-risk glioblastoma after partial removal or early progression

  This study tests whether adding intensified post-surgery treatment helps adults with high-risk glioblastoma live longer without the disease progressing.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07670026

• TTFields with FET-PET–Guided SRS for Recurrent Glioblastoma

  This trial tests whether adding FET-PET-guided stereotactic radiosurgery to TTFields helps adults with recurrent IDH-wildtype glioblastoma live longer than TTFields alone.

  Recruiting Prof. Franciszek Lukaszczyk Memorial Oncology Center · Bydgoszcz · NCT07668869

• Couples Coping Together Against Cancer: A Feasibility and Acceptability Look

  This observational study tests whether a brokered program for patients with cancer and their partners is feasible and acceptable, and whether it may reduce distress over time.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07664579

• EASE: A new approach to help adults with advanced cancer cope with fear of progression

  This study tests a written exposure-based coping program to see if it reduces fear of cancer progression and related distress in adults with advanced solid tumors.

  Recruiting at 2 sites University of Colorado, Boulder · Aurora, Colorado and 1 other locations · NCT07636200

• FT536 injection for recurrent WHO Grade 4 astrocytoma

  This will try a single intratumoral dose of FT536, an off-the-shelf engineered NK‑cell therapy, in adults undergoing repeat surgery for recurrent Grade 4 astrocytoma.

  Recruiting Phase 1 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT07560865

• LRRC15-targeted PET imaging for more precise diagnosis and staging of pancreatic, breast, lung, sarcoma and head-and-neck cancers

  This project tests whether an LRRC15-targeted PET scan can better detect and stage LRRC15-expressing cancers and measures how the tracer behaves in healthy adults.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07552467

• Dual-target CAR-NK therapy for adults with recurrent or progressive glioblastoma and other high-grade gliomas

  This study will try giving dual-target CAR-NK cells into the surgical cavity to see if they can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07551336

• Sitagliptin plus bevacizumab for recurrent grade 4 glioma

  This study tests whether adding sitagliptin to bevacizumab can help people whose recurrent glioblastoma or other grade 4 gliomas respond to treatment and to find a safe dose when used with bevacizumab.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07541781

• Panitumumab-IRDye800 for guiding brain tumor surgery

  A tiny dose of panitumumab-IRDye800 is tested to see if it helps visualize brain tumors during surgery in adults.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07493447

• Local targeted alpha therapy using 225Ac‑DOTA‑SP for newly diagnosed WHO grade 3–4 glioma

  This trial tests a local peptide‑guided alpha‑particle treatment (225Ac‑DOTA‑SP) in adults 18–80 with newly diagnosed WHO grade 3–4 glioma after initial surgery and radiochemotherapy to see if it safely targets residual tumor and improves local control.

  Recruiting at 2 sites Medical University of Warsaw · Warsaw, Poland and 1 other locations · NCT07488754

• Dual-target CAR-NK cell therapy for recurrent glioblastoma and high-grade glioma

  This phase 1 study will test whether injecting dual-target CAR-NK cells into the brain is safe and can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07480941

• Daily temozolomide for older adults with newly diagnosed glioblastoma and unmethylated MGMT promoter

  This trial will test whether a modified daily temozolomide schedule helps people aged 65 and older with newly diagnosed glioblastoma whose tumors have an unmethylated MGMT promoter.

  Recruiting Phase 2 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07476794

• Phase 1 safety and dose-finding of GLIX1 for adults with recurrent or progressive high-grade glioma

  This trial will test whether taking oral GLIX1 daily is safe, tolerable, and shows early anti-tumor activity in adults with recurrent or progressive high-grade glioma.

  Recruiting at 4 sites Phase 1 Tetragon Biosciences Ltd · Palo Alto, California and 3 other locations · NCT07464925

• Using advanced MRI to image the tumor immune environment in glioblastoma

  This project will test whether three advanced MRI methods (CEST, DR-CSI, and ferumoxytol-enhanced MRI) can noninvasively measure immune cells and proteins around glioblastoma tumors in adults preparing for surgery.

  Recruiting Phase 3 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07461948

• Pre-radiation chemotherapy for high-grade glioma

  Researchers are testing whether giving temozolomide before radiation can help patients with newly diagnosed high-grade gliomas see better outcomes and clearer MRI results after treatment.

  Recruiting Phase 2 Cooper Norcross Health · Camden, New Jersey · NCT07439172

• Group occupational therapy program to help adults with primary brain tumours manage daily activities

  This program will try a six-week occupational therapy group to see if it helps adults with primary brain tumours on active treatment improve daily functioning and quality of life.

  Recruiting Royal College of Surgeons, Ireland · Dublin, Beaumont · NCT07426848

• Skin closure after brain tumor surgery: running absorbable versus interrupted non-absorbable sutures

  This will test whether absorbable running intradermal sutures or non-absorbable interrupted transdermal sutures produce better wound healing after craniotomy in adults with supratentorial brain tumors.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT07413796

• Cerebrospinal fluid leak after brain tumor surgery

  This project will look at adults having planned supratentorial craniotomy for intracranial tumors to see how often cerebrospinal fluid leaks occur and what complications they cause.

  Recruiting Medical University of Warsaw · Warsaw · NCT07411690

• EBNK-001 allogeneic NK cell therapy with low-dose IL-15, with or without pembrolizumab, for advanced solid tumors

  This treatment tests an off-the-shelf NK cell product (EBNK-001) given with low-dose IL-15, either alone or with pembrolizumab, in adults with advanced or metastatic solid tumors who have exhausted standard options.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07410676

• Biomarker-guided donor CAR-NK therapy targeting one or two tumor antigens for advanced solid tumors

  This treatment tries donor-derived CAR-NK cells that target one or two tumor antigens for adults with advanced solid tumors such as breast, NSCLC, colorectal, and recurrent prostate cancer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07410494

• CTX-009 alone or with CTX-471 for recurrent glioblastoma

  This study tests CTX-009 by itself and in combination with CTX-471 to see if they can control tumors and help people living with recurrent glioblastoma.

  Recruiting Phase 1/2 Washington University School of Medicine · St Louis, Missouri · NCT07392957

• How Acetadote might affect metabolism in newly diagnosed glioblastoma

  This early-phase trial tests whether Acetadote can change brain tumor metabolism in adults with a new glioblastoma diagnosis.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07387666

• Salovum® to lower tumor pressure, inflammation, and oxygen deficits in glioblastoma

  This trial will test whether taking Salovum®, an egg-yolk product containing antisecretory factor, can reduce pressure inside glioblastoma tumors, change inflammatory cytokine release, and affect tumor oxygen levels in adults having a diagnostic brain biopsy.

  Recruiting Phase 2 Skane University Hospital · Lund · NCT07364786

• Irinotecan-ChemoSeed in Resectable Glioblastoma

  This study tests a targeted chemotherapy seed implanted in the tumor cavity after surgical removal of glioblastoma to see if it is safe and if it helps patients respond better.

  Recruiting Phase 2 CRISM Therapeutics LTD · Birmingham · NCT07356973

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Vortioxetine for newly diagnosed glioblastoma

  Aimed at adults with newly diagnosed glioblastoma, this study tests whether the antidepressant vortioxetine can help alongside standard treatment.

  Recruiting Phase 2 University of Zurich · Zurich · NCT07284628

• Adding senicapoc and perampanel to standard treatment for newly diagnosed glioblastoma

  This trial will test whether giving the drugs perampanel and senicapoc, alone or together, with standard therapy is safe and reaches the brain in adults newly diagnosed with glioblastoma.

  Recruiting Early Phase 1 University of Aarhus · Aarhus, Denmark · NCT07284069

• Early post-operative brain PET-MRI in glioblastoma surgery

  This study tests whether doing PET-MRI soon after glioblastoma surgery is safe and feasible and whether imaging with 18F-DOPA can better detect residual tumor than standard MRI.

  Recruiting Beta Emitting Accurate Monitored Systems · Créteil · NCT07274397

• Trimipramine with atezolizumab and bevacizumab for recurrent glioblastoma

  Researchers will try whether adding the antidepressant trimipramine to the immunotherapy atezolizumab plus bevacizumab helps people with recurrent glioblastoma.

  Recruiting at 7 sites Phase 2 Centre Hospitalier Universitaire Vaudois · Basel, Basel and 6 other locations · NCT07263438

• Standard temozolomide plus 5‑ALA and low‑intensity ultrasound after surgery for newly diagnosed glioblastoma

  This trial tests whether adding the light‑activated drug 5‑ALA together with a low‑intensity ultrasound device to standard temozolomide can help people with newly diagnosed glioblastoma after surgery and chemoradiation.

  Recruiting at 11 sites Phase 2 Alpheus Medical, Inc. · Boston, Massachusetts and 10 other locations · NCT07225621

• Immediate radiation with GammaTile during glioblastoma surgery versus standard timing

  This trial tests whether placing GammaTile at the time of surgery to start radiation right away, combined with temozolomide, helps adults with newly diagnosed glioblastoma compared with the usual delayed external beam radiation schedule.

  Recruiting at 22 sites Phase 3 GT Medical Technologies, Inc. · Scottsdale, Arizona and 21 other locations · NCT07195591

• Understanding Glioblastoma Recurrence and Progression Through Blood and Tumor Samples

  This study will test blood and tumor samples from adults with newly diagnosed or recurrent glioblastoma to explore the molecular and immune factors involved in tumor growth and relapse.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07173829

• MRI‑guided laser ablation plus lomustine for recurrent glioblastoma

  This study will test whether a focused MRI‑guided laser ablation followed about a week later by the chemotherapy lomustine is safe and doable for adults whose glioblastoma has returned.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT07145112

• Surgery plus intraoperative balloon electronic brachytherapy with the Xoft Axxent system for newly diagnosed glioblastoma.

  This trial will test whether adding intraoperative balloon electronic brachytherapy with the Xoft Axxent system during tumor removal helps people aged 40–75 with newly diagnosed glioblastoma.

  Recruiting Phase 1 Joint Stock Company European Medical Centre · Moscow, Moscow · NCT07141732

• Giving immunotherapy before standard treatment for newly diagnosed glioblastoma

  This Phase 1 trial tests whether giving two doses of the immunotherapy drug ipilimumab before surgery is safe and may help people with newly diagnosed glioblastoma or gliosarcoma.

  Recruiting Phase 1 University College, London · London, Greater London · NCT07134842

• APTw-CEST MRI to detect glioblastoma progression after radiotherapy

  This study tests whether a special MRI method called APTw-CEST can tell adults with glioblastoma who have had radiotherapy or chemoradiotherapy whether new MRI changes mean true tumor growth or just treatment-related pseudoprogression.

  Recruiting at 3 sites Erasmus Medical Center · Amsterdam and 3 other locations · NCT07121842

• FAPI PET/MR imaging of fibroblast activity in glioblastoma

  This will try a FAPI PET/MR scan to image fibroblast activation in adults with a suspected or recurrent glioblastoma.

  Recruiting Jules Bordet Institute · Brussels · NCT07119294

• TLX101-Tx plus standard care versus standard care alone for recurrent glioblastoma

  This test checks whether adding TLX101-Tx, a tumor-targeted radiopharmaceutical given with lomustine, helps adults with first-recurrence glioblastoma control their tumor or live longer compared with lomustine alone.

  Recruiting at 7 sites Phase 3 Telix Pharmaceuticals (Innovations) Pty Limited · Gold Coast, Queensland and 8 other locations · NCT07100730

• VRT106 injections for recurrent or progressive glioblastoma.

  This trial will test whether injections of VRT106 are safe and can help adults aged 18–70 with recurrent or progressive glioblastoma.

  Recruiting at 5 sites Phase 1/2 Guangzhou Virotech Pharmaceutical Co., Ltd. · Hefei, Anhui and 10 other locations · NCT07093814

• ERAS-801 for operable or recurrent EGFR-altered IDH-wildtype Grade IV glioblastoma or astrocytoma

  This trial tests ERAS-801, a brain-penetrant EGFR blocker, to see if it is safe and changes tumor metabolism in adults with resectable or recurrent IDH-wildtype Grade IV glioblastoma or astrocytoma that have EGFR amplification or mutation.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California and 1 other locations · NCT07089641

• PSMA PET/CT for GBM patients on bevacizumab

  This study tests PSMA PET/CT scans in adults with IDH-wildtype glioblastoma who are receiving bevacizumab to see how PSMA expression relates to VEGF in their tumors.

  Recruiting Royal North Shore Hospital · Saint Leonards, New South Wales · NCT07052877

• Phase 2 pharmacodynamic test of sitagliptin for progressive grade 4 glioma

  This trial will try sitagliptin in adults with progressive grade 4 glioma to see if it lowers immune-suppressing MDSCs and boosts anti-tumor immune activity before surgery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07003542

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Local targeted therapy for recurrent glioblastoma using alpha emitter.

  This study is testing a new targeted treatment for adults with recurrent high-grade gliomas to see if it can help them after standard therapies have failed.

  Recruiting at 2 sites Medical University of Warsaw · Warsaw, Poland and 1 other locations · NCT06975332

• Enhanced treatment for newly diagnosed glioblastoma after surgery

  This study is testing a new treatment plan for people with newly diagnosed glioblastoma after surgery to see if a combination of different drugs and higher radiation doses works better than the usual care.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT06936046

• Testing new drug combinations for glioblastoma treatment

  This study is testing new combinations of drugs to see if they can safely help people with recurrent or newly diagnosed glioblastoma, an aggressive type of brain cancer.

  Recruiting at 11 sites Phase 1 Memorial Sloan Kettering Cancer Center · Los Angeles, California and 10 other locations · NCT06934889

• Evaluating the use of Optune Gio® in patients with newly diagnosed Glioblastoma in France

  This study is testing if the Optune Gio® device can help people with newly diagnosed Glioblastoma live longer and feel better after their treatment.

  Recruiting at 24 sites NovoCure Ltd. · Amiens and 23 other locations · NCT06924099

• Neoadjuvant chemoradiotherapy with or without azeliragon for newly diagnosed glioblastoma

  This will test whether adding azeliragon to standard radiation and temozolomide before repeat tumor sampling can reduce immune-suppressive myeloid cells and boost T-cell activity in adults with newly diagnosed glioblastoma.

  Recruiting Early Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT06831526

• Pharmacoscopy-guided treatment for refractory brain tumors

  This trial tests whether personalized drug testing on a patient’s tumor cells can guide treatment choices for adults with hard-to-treat brain cancers like glioblastoma.

  Recruiting Phase 2 University of Zurich · Basel, Basel-Landschaft and 2 other locations · NCT06804655

• Understanding brain blood flow and metabolism in patients with brain lesions

  This study is trying to understand how blood flow and metabolism in the brain are affected in patients with brain tumors like glioblastoma, glioma, and astrocytoma.

  Recruiting Erasme University Hospital · Brussels · NCT06797661

• Testing drug responses using glioblastoma organoids

  This study is testing if lab-grown brain tumor samples from patients can help predict how well different drugs will work for their glioblastoma treatment.

  Recruiting Chungnam National University Hospital · Daejeon, Chungcheongnam-do · NCT06782984

• Hypofractionated radiotherapy for glioblastoma treatment

  This study is testing a new way of giving radiation therapy combined with a medication for people with newly diagnosed glioblastoma to see if it helps them live longer.

  Recruiting The First Hospital of Jilin University · Changchun, Jilin · NCT06740955

• Limiting the radiation target area for glioblastoma to reduce treatment side effects

  This trial will test whether giving radiotherapy with a smaller margin around the tumor (10 mm instead of 15 mm) for adults with newly diagnosed glioblastoma can reduce side effects and improve quality of life.

  Recruiting at 18 sites Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Aalst and 22 other locations · NCT06719440

• Effects of Salovum® and SPC® Flakes on Brain Tumor Edema

  This study is testing if eating Salovum® and SPC® flakes can help reduce swelling in the brain and improve symptoms for people with certain types of brain tumors.

  Recruiting Phase 2 Skane University Hospital · Lund · NCT06710249

• Testing ivonescimab for recurrent glioblastoma

  This study is testing a new treatment called ivonescimab to see if it can help adults with recurrent glioblastoma feel better and manage their disease after other treatments have failed.

  Recruiting at 2 sites Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas and 1 other locations · NCT06672575

• Imaging study using two antibody fragments in patients with solid tumors

  This study is testing two special antibody fragments in people with solid tumors to see how well they target cancer cells and how they move through the body.

  Recruiting Early Phase 1 Var2 Pharmaceuticals · Groningen, Provincie Groningen · NCT06645808

• Combining TIL Therapy and Pembrolizumab for Advanced Brain Cancer

  This study is testing a new treatment that combines a type of immune therapy using patients' own tumor cells with Pembrolizumab to see if it helps people with advanced brain cancer feel better and live longer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06640582

• Investigating factors affecting glioblastoma outcomes

  This study is looking to see how different health and lifestyle factors affect the survival and quality of life for adults with glioblastoma, a tough type of brain cancer.

  Recruiting Duke University · Durham, North Carolina · NCT06625684

• Advanced imaging techniques for brain tumor surgery

  This study is testing if advanced imaging techniques can help doctors remove brain tumors more accurately in patients with certain types of glioblastoma to improve their outcomes.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06623565

• Metabolic profiling of glioblastoma using advanced imaging techniques

  This study is testing new imaging techniques to see how glioblastoma tumors use energy and nutrients, which could help doctors understand the tumors better and improve treatment options.

  Recruiting at 2 sites Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT06613841

• Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents

  This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.

  Recruiting Phase 1/2 Fundación de investigación HM · Boadilla del Monte, Madrid · NCT06607692

• Testing Troriluzole for recurrent glioblastoma treatment

  This study is testing if Troriluzole can help people with recurrent glioblastoma feel better when given before and after surgery compared to just after surgery.

  Recruiting at 3 sites Early Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT06552260

• Pre-surgery ultrahypofractionated stereotactic radiotherapy with targeted dose boost for glioblastoma

  This trial will test whether a short course of focused pre-surgery stereotactic radiotherapy with an extra, imaging-guided dose boost helps people with operable glioblastoma.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06551909

• Personalized treatment for glioblastoma using patient-derived drug screening

  This study is testing if creating personalized treatment plans using patients' own cancer cells can help people with glioblastoma get better results than standard treatment alone.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06512311

• Evaluating Bevacizumab with Focused Ultrasound for Recurrent Glioblastoma

  This study is testing if adding focused ultrasound to the standard treatment of Bevacizumab can help people with recurrent glioblastoma feel better and live longer.

  Recruiting at 2 sites Phase 3 NaviFUS Corporation · Taipei and 1 other locations · NCT06496971

• Glioma adaptive radiotherapy using an AI-driven dose plan

  This trial tests whether using AI to guide adaptive radiation can improve treatment for adults with diffuse gliomas.

  Recruiting Phase 2 Tata Memorial Centre · Mumbai, Maharatshtra · NCT06492486

• Neoadjuvant radiochemotherapy for glioblastoma treatment

  This study is testing a new combination of radiation and chemotherapy before surgery to see if it helps people with glioblastoma feel better and live longer compared to standard treatment.

  Recruiting Phase 1 Hospital San Carlos, Madrid · Madrid · NCT06418113

• Mental health and resilience in people with glioblastoma or head and neck cancer

  We will see how common different psychological and psychiatric problems are, and whether resilience helps protect against them, in adults with glioblastoma or head-and-neck cancer who are receiving curative long-course radiotherapy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06385132

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Evaluating anthracycline treatment after radiotherapy for glioblastoma in young patients

  This study tests if adding a heart-safe version of doxorubicin to radiotherapy and temozolomide can help young patients with glioblastoma do better than with standard treatments.

  Recruiting Phase 2 Meyer Children's Hospital IRCCS · Florence · NCT06297512

• Comparing surgery and best treatment for recurrent glioblastoma

  This study is testing whether surgery or the best available treatment helps people with recurring glioblastoma feel better and live longer.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06283927

• Resection techniques for recurrent glioblastoma

  This study is testing different methods of mapping the brain during surgery for recurring glioblastoma to see which one helps patients keep their movement and speech abilities while removing as much of the tumor as possible.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06273176

• Investigating biomarkers in glioblastoma patients treated with TTFields

  This study is testing how well a new treatment called TTFields works for people with newly diagnosed glioblastoma by looking for signs in their blood and tumors that show if they respond to the treatment.

  Recruiting Institut Claudius Regaud · Toulouse · NCT06222138

• E-SYNC CAR T cell therapy for EGFRvIII positive glioblastoma

  This study is testing a new type of CAR T cell therapy to see if it can help people with a specific type of brain cancer called EGFRvIII positive glioblastoma after they have had chemotherapy.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06186401

• Using advanced MRI to improve radiotherapy for glioblastoma

  This study is testing whether using advanced MRI techniques can help doctors better target glioblastoma tumors during radiotherapy, aiming to protect healthy tissue while effectively treating the cancer.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06183983

• pH-sensitive MRI-guided resection for glioblastoma

  This trial will test whether using a pH-sensitive MRI scan (CEST‑EPI) to guide more extensive surgery can help adults with newly diagnosed or recurrent IDH‑wildtype glioblastoma by finding and removing infiltrative tumor beyond standard imaging.

  Recruiting Phase 1 University of California, Los Angeles · Los Angeles, California · NCT06176066

• Testing PLX038 for brain and spinal cord tumors with MYC or MYCN amplifications

  This study is testing a new treatment called PLX038 for adults with brain and spinal cord tumors that have specific gene changes to see if it helps improve their condition.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06161519

• Comparing palliative care and surgery for high-grade glioma patients

  This study is testing whether palliative care or surgery helps people with high-grade glioma live longer and feel better.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146738

• Comparing tumor resection and biopsy for high-grade glioma patients

  This study is testing whether removing a brain tumor or just taking a small sample helps older patients with high-grade gliomas live longer and feel better afterward.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146725

• Treatment for glioblastoma using radiofrequency electromagnetic fields and chemotherapy

  This study is testing whether combining radiofrequency electromagnetic field treatment with standard chemotherapy can help people with newly diagnosed glioblastoma feel better and improve their outcomes.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06140875

• Pre-surgery and pre-radiotherapy Tumour Treating Fields (Optune) for glioblastoma

  This will test whether using Optune (Tumour Treating Fields) before surgery and again before radiotherapy is safe and workable for adults with a new glioblastoma diagnosis.

  Recruiting The Christie NHS Foundation Trust · Manchester · NCT06136611

• Immunotherapy for CMV Antigens in Glioblastoma

  A phase 1 trial tests the PEP-CMV vaccine in adults with newly diagnosed, MGMT-unmethylated glioblastoma who have CMV exposure and have had surgery and initial chemoradiation.

  Recruiting at 2 sites Phase 1 The University of New South Wales · Liverpool, New South Wales and 1 other locations · NCT06132438

• Comparing two surgical approaches for high-grade glioma patients

  This study is testing whether a more extensive surgical method for removing high-grade brain tumors helps patients live longer and feel better compared to a standard approach.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06118723

• Identifying glioblastoma pseudoprogression using imaging and biomarkers

  This study is testing new imaging and blood tests to help doctors tell the difference between false signs of tumor growth and real tumor progression in patients with glioblastoma.

  Recruiting Istituto Clinico Humanitas · Rozzano · NCT06113705

• Evaluating RZ-001 with Valganciclovir for Glioblastoma

  This study is testing a new treatment combining RZ-001 and Valganciclovir to see if it can help people with a specific type of brain cancer called glioblastoma.

  Recruiting at 6 sites Phase 1/2 Rznomics, Inc. · Incheon and 5 other locations · NCT06102525

• Using MRI to understand brain tumor biology in patients with glioblastoma

  This study is testing if MRI scans can help doctors understand brain tumors in patients with glioblastoma to see who might benefit from a specific treatment.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06090903

• Testing BDTX-1535 for patients with recurrent high-grade glioma and glioblastoma

  This study is testing a new drug called BDTX-1535 to see if it can help patients with recurrent high-grade glioma or newly diagnosed glioblastoma who have certain changes in the EGFR protein.

  Recruiting at 2 sites Early Phase 1 St. Joseph's Hospital and Medical Center, Phoenix · Chandler, Arizona and 1 other locations · NCT06072586

• Using Trastuzumab Deruxtecan to treat brain cancer

  This study is testing if a new drug called trastuzumab deruxtecan can effectively treat brain cancer in adults with specific types of tumors that have the HER2 protein.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06058988

• MRI-guided radiotherapy for cancer treatment

  This study is testing a new way of giving radiation therapy for cancer that uses MRI technology to better target tumors and improve treatment for patients with different types of cancer.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06041555

• Monitoring soluble CD146 levels in glioblastoma patients treated with bevacizumab

  This study is testing if tracking a specific protein in the blood can help understand how well glioblastoma patients are responding to treatment with bevacizumab.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT06001281

• Blocking blood supply to treat glioblastoma

  This study is testing a new procedure that blocks blood flow to glioblastoma tumors to see if it can help the immune system fight the cancer better in people who haven't had treatment yet.

  Recruiting First Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT05990556

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Testing WSD0628 with radiation for recurrent brain tumors

  This study is testing a new drug called WSD0628 combined with radiation to see if it can help adults with recurrent brain tumors like glioblastoma feel better and improve their treatment outcomes.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT05917145

• Combining eflornithine and temozolomide for newly diagnosed glioblastoma

  This study is testing a new combination of two medications, eflornithine and temozolomide, to find the best dose for people with newly diagnosed glioblastoma.

  Recruiting at 7 sites Phase 1 Orbus Therapeutics, Inc. · Birmingham, Alabama and 7 other locations · NCT05879367

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Liposomal Curcumin with Radiotherapy and Temozolomide for High-Grade Gliomas

  This study is testing if adding a new treatment called Liposomal Curcumin to standard radiotherapy and Temozolomide can be safe and effective for people newly diagnosed with high-grade gliomas.

  Recruiting at 2 sites Phase 1/2 SignPath Pharma, Inc. · Washington D.C., District of Columbia and 1 other locations · NCT05768919

• Escalated dose proton therapy for glioblastoma patients

  This study is testing higher doses of proton therapy for patients with glioblastoma to find out the safest amount they can tolerate while receiving other treatments.

  Recruiting at 2 sites University of Aarhus · Aarhus, Central Jutland and 1 other locations · NCT05768087

• Collecting and preserving glioblastoma tissue during surgery for future research

  This study is collecting and saving glioblastoma tumor tissue and blood samples during surgery to help researchers learn more about the disease and find better treatments.

  Recruiting Baptist Health South Florida · Miami, Florida · NCT05756985

• Combining Temozolomide with Abexinostat for Recurrent Glioma Treatment

  This study is testing a new combination of two drugs, Temozolomide and Abexinostat, to see if it can help people with recurrent high-grade gliomas like glioblastoma feel better and manage their condition.

  Recruiting Phase 1 University of Nebraska · Omaha, Nebraska · NCT05698524

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Preventing blood clots in outpatients with newly diagnosed grade 4 glioma using apixaban

  This trial will test whether taking apixaban can prevent dangerous blood clots in adults newly diagnosed with grade 4 glioma.

  Recruiting Phase 2 University of Vermont Medical Center · Burlington, Vermont · NCT05683808

• Using egg powder to improve outcomes in glioblastoma patients

  This study is testing if a special egg powder can help people with newly diagnosed glioblastoma live longer and improve their treatment outcomes when taken during their therapy.

  Recruiting Phase 2/3 Skane University Hospital · Lund · NCT05669820

• Using glutamate inhibitors to treat glioblastoma

  This study is testing if adding certain medications that block glutamate can help improve treatment outcomes for people with newly diagnosed glioblastoma when used with standard chemotherapy and radiation.

  Recruiting Phase 1/2 University of Zurich · Zurich, Canton of Zurich · NCT05664464

• Using CARv3-TEAM-E T Cells to treat glioblastoma

  This study is testing the best dose of a new type of immune cell treatment for people with glioblastoma, a serious brain cancer, to see how safe and effective it is.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT05660369

• FDOPA PET-guided IMRT simultaneous-integrated boost for recurrent glioblastoma

  This trial will try using FDOPA PET scans to guide a higher‑dose simultaneous‑integrated boost IMRT re-irradiation for adults with recurrent glioblastoma to better target tumor while protecting healthy brain.

  Recruiting Phase 2 Centre Paul Strauss · Nancy, De and 1 other locations · NCT05653635

• Using Gliolan with Radiotherapy for Recurrent Brain Tumors

  This study is testing if a new drug called Gliolan can make radiotherapy more effective for patients with recurrent brain tumors after surgery.

  Recruiting Phase 1/2 Universität Münster · Münster · NCT05590689

• Recording brain activity during surgery for high-grade glioma

  This study is testing if recording brain activity during surgery for high-grade glioma tumors can help us understand how these tumors interact with brain cells to improve treatment options.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05565118

• Comparing two types of radiotherapy with temozolomide for elderly glioblastoma patients

  This study is testing whether two different types of radiotherapy, along with a medication called temozolomide, can help older patients with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Severance Hospital · Seoul · NCT05439278

• Collection of biological samples for diagnosing rare neurological diseases

  This study is collecting blood and spinal fluid samples from people with rare neurological diseases to see if they can find new markers that help diagnose these conditions more accurately.

  Recruiting Hospices Civils de Lyon · Bron · NCT05370079

• Evaluating the safety of a new treatment for certain cancer types

  This study is testing a new treatment for certain types of cancer to see if it's safe for adults with recurrent or metastatic tumors.

  Recruiting at 4 sites Phase 1 Orano Med LLC · Chicago, Illinois and 7 other locations · NCT05283330

• Noninvasive detection of glioblastoma using sonobiopsy

  This study is testing a new noninvasive method called sonobiopsy to see if it can help doctors better detect and understand glioblastoma in patients.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05281731

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Testing if lab drug screening can predict cancer treatment responses

  This study is testing if a new way of checking how tumors respond to different cancer treatments can help doctors choose the best options for patients with solid tumors like bladder or kidney cancer.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT05231655

• Evaluating the CONVIVO System for Brain Tumor Surgery

  This study is testing a new imaging tool during brain tumor surgery to see if it can better tell the difference between healthy and unhealthy brain tissue for patients with brain tumors.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT05139277

• Combining Ibrutinib and Indoximod for Pediatric Brain Cancer Treatment

  This study is testing a new combination of two drugs, ibrutinib and indoximod, to see if they can safely help children and young adults with hard-to-treat brain tumors feel better.

  Recruiting Phase 1 Augusta University · Augusta, Georgia · NCT05106296

• Using Imipramine and Lomustine to treat recurrent glioblastoma

  This study is testing whether a combination of Imipramine and Lomustine can help people with recurrent glioblastoma whose tumors have continued to grow after other treatments.

  Recruiting Phase 2 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT04863950

• Comparing proton and photon radiation therapy for glioblastoma

  This study is testing whether proton beam therapy is better than traditional photon beam therapy for treating glioblastoma by looking at side effects in patients during the first four months of treatment.

  Recruiting University Hospital Heidelberg · Heidelberg and 2 other locations · NCT04752280

• Using ONC206 to treat newly diagnosed and recurrent brain tumors in children and young adults

  This study is testing a new treatment called ONC206, alone or with radiation, to see if it can help children and young adults with newly diagnosed or recurring brain tumors feel better.

  Recruiting at 7 sites Phase 1 University of California, San Francisco · San Francisco, California and 6 other locations · NCT04732065

• Using laser therapy and radiation to treat newly diagnosed gliomas

  This study is testing a new treatment that combines laser therapy and radiation to see if it helps people with newly diagnosed brain tumors called gliomas.

  Recruiting at 5 sites University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT04699773

• Treatment of advanced cancers with RSC-1255

  This study is testing a new oral drug called RSC-1255 to see if it can help adults with advanced cancers that haven't responded to other treatments.

  Recruiting at 3 sites Phase 1 RasCal Therapeutics, Inc. · Los Angeles, California and 2 other locations · NCT04678648

• Chemotherapy and radiation therapy for treating certain types of gliomas

  This study is testing if a combination of a chemotherapy drug and radiation therapy can help people with certain types of brain tumors live longer and feel better.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04623931

• Customized video to reduce anxiety for brain tumor patients and caregivers during radiation treatment

  This study tests if a personalized video can help reduce anxiety for brain tumor patients and their caregivers during radiation treatment.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04479696

• Exploring a new treatment for newly diagnosed glioblastoma

  This study is testing a new treatment that combines L19TNF with standard chemotherapy for people who have just been diagnosed with glioblastoma to see if it works better than the usual treatment alone.

  Recruiting Phase 1/2 Philogen S.p.A. · Zurich · NCT04443010

• Restricting Dexamethasone Use in Glioblastoma Treatment

  This study is testing if newly diagnosed glioblastoma patients can do well without the usual steroid treatment to see if it helps them avoid side effects and improve their outcomes.

  Recruiting Insel Gruppe AG, University Hospital Bern · Sankt Gallen, St.Gallen and 3 other locations · NCT04266977

• Using MRI scans to monitor cancer treatment response during radiation therapy

  This study is testing if regular MRI scans can help doctors see how well radiation therapy is working for patients with advanced cancers like glioblastoma and esophageal cancer.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04188535

• Implantable microdevice to test drug effects in primary brain tumors

  A tiny implantable device is placed into your glioma during surgery to see if local releases of standard glioma drugs cause tumor responses.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT04135807

• Using microdialysis during brain surgery to collect biomarkers for tumors

  This study is testing if a special device used during brain surgery can help doctors collect important information about brain tumors to improve diagnosis and treatment for patients with these conditions.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04047264

• Evaluating therapies for newly diagnosed and recurrent glioblastoma

  This study is testing different treatments for people with newly diagnosed or recurring glioblastoma to see which ones work best for different types of the disease.

  Recruiting at 38 sites Phase 2/3 Global Coalition for Adaptive Research · Birmingham, Alabama and 62 other locations · NCT03970447

• Comparing awake craniotomy and general anesthesia for glioblastoma surgery

  This study is testing whether having brain surgery while awake is safer and more effective than having it under general anesthesia for people with glioblastoma in important areas of the brain.

  Recruiting at 5 sites Erasmus Medical Center · Ghent and 4 other locations · NCT03861299

• Evaluating progastrin levels in cancer patients

  This study is testing if measuring progastrin levels in the blood can help predict how cancer will progress and respond to treatment in patients with different types of cancer.

  Recruiting at 17 sites Hospices Civils de Lyon · Bron and 16 other locations · NCT03787056

• Combining Bortezomib and Temozolomide for Recurrent Glioblastoma

  This study is testing if giving Bortezomib before Temozolomide can help people with recurrent glioblastoma live longer and feel better by making the chemotherapy work more effectively.

  Recruiting at 2 sites Phase 1/2 Haukeland University Hospital · Bergen and 1 other locations · NCT03643549

• Gene therapy combined with radiation and chemotherapy for newly diagnosed brain tumors

  This study is testing a new gene therapy combined with radiation and chemotherapy to see if it can help people who have just been diagnosed with aggressive brain tumors like glioblastoma or anaplastic astrocytoma.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03603405

• AI-based precision oncology clinical trial matching and registry

  This study is testing whether an AI tool can help match cancer patients with the right clinical trials based on their specific cancer details to see if it improves their chances of getting into trials and their overall outcomes.

  Recruiting at 68 sites Massive Bio, Inc. · Birmingham, Alabama and 67 other locations · NCT03452774

• Intracranial NK-92 cell injections plus IV ezabenlimab for recurrent HER2‑positive glioblastoma

  This trial will test whether injecting engineered NK-92 immune cells into the brain together with intravenous ezabenlimab is safe and shows signs of benefit in adults with recurrent HER2‑positive glioblastoma.

  Recruiting at 5 sites Phase 1 Johann Wolfgang Goethe University Hospital · Heidelberg, Baden-Wurttemberg and 4 other locations · NCT03383978

• Combining capecitabine and temozolomide for newly diagnosed glioblastoma

  This study is testing if combining two cancer drugs, capecitabine and temozolomide, can help people with newly diagnosed glioblastoma live longer and feel better compared to using temozolomide alone.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT03213002

• Biomarkers to predict 6‑month survival with Avastin in first‑relapse glioblastoma

  This project will test whether early MRI spectroscopy markers can predict which people with first‑relapse glioblastoma treated with Avastin will live six months or longer.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT03144167

• Individualized treatment for Glioblastoma using new drugs

  This study is testing new drugs for people with glioblastoma to see if they work better than the standard treatment.

  Recruiting at 4 sites Phase 2 Dana-Farber Cancer Institute · Birmingham, Alabama and 11 other locations · NCT02977780

• Treatment of newly diagnosed glioblastoma using targeted drug infusion

  This study is testing a new way to deliver a targeted drug directly to the brain tumor in people with newly diagnosed glioblastoma to see if it can improve their treatment outcomes.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT02861898

• Targeting brain tumors with a specific drug infusion and re-irradiation

  This study is testing a new way to deliver a drug directly to brain tumors in patients with certain aggressive types of glioblastoma to see if it can improve treatment results.

  Recruiting Phase 2 Northwell Health · New York, New York · NCT02800486

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (newest 40 of 471)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Small molecules to block Slit2/ROBO in glioblastoma

  A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11616958

• Immunotherapy for glioblastoma: advancing treatment and understanding

  A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11608606

• Small-molecule and biologic treatments for glioblastoma using targeted brain delivery

  A new approach aims to use FPS-ZM1 to shrink brain swelling and support immunotherapy for glioblastoma, potentially helping patients recover after surgery.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11608579

• Targeted therapies for glioblastoma in adults and kids

  A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11608562

• 6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery

  A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.

  NIH research Duke University · Durham, United States · NIH-11607175

• CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma

  A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.

  NIH research West Virginia University · Morgantown, United States · NIH-11579310

• Role of a brain tumor RNA in glioblastoma where a unique lncRNA may drive cancer cells

  A small, focused NIH grant explores how a brain cancer–related RNA called LINC01896 might control the growth of glioblastoma stem cells and influence treatment resistance.

  NIH research University of New Haven · West Haven, United States · NIH-11516889

• BAI3 in glioblastoma: how a brain protein isoform could help patients

  A small NIH grant is exploring how a brain protein called BAI3, produced in two forms, may affect glioblastoma and patient survival.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11498746

• Overcoming Immune Blockade Resistance in Glioblastoma with a Patient-Derived Stem Cell Therapy

  A new therapy using your own stem cells grown outside your body is being explored to help people with glioblastoma who no longer respond to current immune therapies.

  NIH research Ioncologi INC · Gainesville, United States · NIH-11457448

• How glioblastoma changes across the tumor and over time during treatment

  This work maps how glioblastoma tumors shift their cell types and interactions during and after treatment to find weaknesses that could help people with recurrent GBM.

  NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11457140

• AHR-driven immunosuppression in glioblastoma and new therapeutic targets

  A personalized cancer study aims to understand why glioblastoma suppresses the immune system and to find ways to boost anti-tumor immunity in patients with this brain tumor.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11455312

• Understanding why some glioblastoma patients respond long-term to an ATL-DC vaccine

  A study in glioblastoma patients exploring why a personalized vaccine made from a patient’s own tumor blood cells helps some people live longer.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11453574

• Sex-specific role of GABA signaling in glioblastoma immune response

  A study in people with glioblastoma to understand how GABA signaling in immune cells may influence tumor progression and treatment responses, with a focus on sex differences.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11452828

• Understanding glioblastoma necrosis to find new therapeutic targets

  Researchers are studying why a deadly brain cancer called glioblastoma becomes so aggressive, with a focus on necrosis and a cell death process that may open doors to new treatments for adults living with this disease.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11448748

• Restoring dendritic-cell signaling to boost brain tumor T cells

  Aims to re-activate the immune system inside the brain to better fight glioblastoma in adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447511

• Epigenetic rules of brain tumor cell states in glioblastoma

  This grant studies how glioblastoma cells change states at the epigenetic level to resist therapy, with mouse models and single-cell profiling.

  NIH research Duke University · Durham, United States · NIH-11447009

• Dual-hypoxia and proliferation PET biomarker for recurrent glioblastoma

  A study using a special PET imaging approach to map oxygen-poor areas and cell growth in recurrent brain tumors to guide treatment decisions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11445726

• Brain Calcium Channels and Glioblastoma: New Ways to Tame a Deadly Brain Cancer

  This grant studies how calcium channels in brain cells influence glioblastoma growth and whether blocking them can lead to new therapies for this very aggressive brain tumor.

  NIH research University of Virginia · Charlottesville, United States · NIH-11442852

• GlycoRNA clues in glioblastoma: a new path to diagnosis and therapy

  A small grant is testing a new type of molecular signal called glycoRNAs in glioblastoma to see if it can reveal how the cancer hides from the immune system and help guide new treatments.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11440804

• Epigenetic Reprogramming to Target GBM Signaling in CARM1-Deficient Tumors

  Aimed at adults with glioblastoma, this grant explores how epigenetic changes affect cancer cell signaling and whether targeting these pathways could make tumors more treatable.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11436847

• BiViSTA: a glow-in-the-dark virus sensor that helps kill brain tumors

  A patient-friendly project to make glioblastoma therapy safer and more effective by using a bioluminescent viral sensor to trigger targeted tumor cell death.

  NIH research Central Michigan University · Mount Pleasant, United States · NIH-11424537

• Targeting death receptors to boost MET-CAR T cells for glioblastoma

  Aims to make MET-CAR T cells work better against glioblastoma by using radiation to trigger death receptors on tumor cells.

  NIH research East Tennessee State University · Johnson City, United States · NIH-11424532

• NF1-Driven Glioblastoma: Targeting MAPK Signaling in Adults

  A new program will test a brain-penetrant MEK inhibitor for adults with NF1-related or NF1-mutant glioblastoma to slow tumor growth and improve outcomes.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11422878

• Liquid biopsy and oxygen therapy to guide glioblastoma treatment

  A patient-focused study exploring a blood-based test and a safe oxygen therapy to help doctors tell true tumor growth from treatment effects in adults with glioblastoma treated with chemoradiation.

  NIH research Nuvox Pharma, LLC · Tucson, United States · NIH-11420569

• Understanding glioblastoma and its communication with brain cells and the immune system

  A large NIH grant aims to map how glioblastoma cancer cells talk to neurons and immune cells, with the goal of finding new ways to treat this aggressive brain tumor.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11420536

• How tumor metabolism controls protein-making in glioblastoma

  Researchers are testing metabolic and diet-based approaches to slow protein-making and tumor growth in people with glioblastoma.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11420517

• RNA-lipid vaccine approach for glioblastoma in newly diagnosed patients

  A new RNA-lipid particle vaccine is being tested to help the body’s own immune system fight glioblastoma in people who have just been diagnosed.

  NIH research University of Florida · Gainesville, United States · NIH-11420160

• EGFR signaling changes to help GBM cells cope with membrane stress

  A study in glioblastoma researchers will map how EGFR and its mutant EGFRvIII help cancer cells survive membrane stress and methuosis, using computer modeling and lab experiments.

  NIH research University of Virginia · Charlottesville, United States · NIH-11418085

• Neoepitope Vaccine with Intratumoral Oncolytic Virus for Glioblastoma

  A personalized tumor vaccine combined with a targeted virus therapy is being tested to boost immune attack against glioblastoma in patients.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11417400

• Understanding and Overcoming T cell Immunosuppression in Glioblastoma (GBM)

  A large research program is looking at how glioblastoma tumors weaken immune responses and how to boost immune cells to fight GBM.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11417398

• Murine brain tumor model to test herpes-based cancer therapy

  Researchers will develop a mouse model of aggressive brain tumors to safely test herpes-based viral therapies aimed at treating malignant glioblastoma.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11416177

• Engineered GBM-targeted T cells guided by photothermal nanoparticles

  A personalized cell therapy approach uses a patient’s own tumor cells and immune cells, activated by a light-activated nanoparticle to help fight glioblastoma.

  NIH research Immunoblue, LLC · Baltimore, UNITED STATES · NIH-11415186

• Engineered T cells that light up imaging targets in glioblastoma

  Aims to create specially designed T cells that reveal glioblastoma markers using PET imaging, helping doctors see tumors and track CAR-T cells in living patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11415015

• Spatial imaging of whole tumor genomics in glioblastoma

  A patient-centered look at how mapping all regions of a glioblastoma tumor in 3D could reveal common genetic targets and help guide future therapies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11413784

• Telomerase-Targeted Therapy Plus Radiation for Glioblastoma in Veterans

  A new treatment approach uses a telomerase-targeting drug with radiation to try to shrink glioblastoma tumors in veterans.

  NIH research Southern Arizona VA Health Care System · Tucson, United States · NIH-11413201

• Overcoming Radiation Resistance in Glioblastoma by Targeting Cell Fate Transitions

  A Duke University study aims to make radiation therapy more effective for glioblastoma patients by blocking how cancer cells change into a resistant state.

  NIH research Duke University · Durham, United States · NIH-11412228

• Alphavirus-delivered peptide therapy for glioblastoma (GSC-targeted)

  A new treatment approach uses a virus-based system to deliver a small protein fragment that specifically kills glioblastoma stem cells, potentially slowing tumor growth and improving survival.

  NIH research Acomhal Research, INC. · Roanoke, United States · NIH-11409740

• Sonodynamic therapy for recurrent glioblastoma using MRI-guided focused ultrasound and ALA

  A new treatment combines a drug called 5-ALA with MRI-guided focused ultrasound to target recurrent glioblastoma tumors.

  NIH research Sonalasense INC · San Carlos, UNITED STATES · NIH-11408427

• Understanding how a brain tumor protein stops glioblastoma from spreading

  Aims to learn how a brain-specific protein, ADGRB1/BAI1, prevents glioblastoma cells from invading nearby brain tissue and to explore new treatments that could help patients with this deadly cancer.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11406086

• Restore immune cells’ ability to eat glioblastoma cells by targeting QKI/PPARb/RXRa in GBM

  Aimed at helping people with glioblastoma by boosting how brain immune cells eat tumor cells and present them to the immune system.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11404904

Related topics

Quick answers

How many Glioblastoma clinical trials are recruiting right now?

151, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (76 trials), Netherlands (15 trials), Germany (14 trials), Switzerland (14 trials), China (12 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 27, Phase 2: 26, Phase 1/2: 17, Early Phase 1: 11. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →