Comparing surgery and best treatment for recurrent glioblastoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This international, multicenter, prospective observational cohort study aims to compare the effects of tumor resection versus best oncological treatment for patients with recurrent glioblastoma. Patients will be assigned to either treatment option at a 1:1 ratio based on a tumor board decision. The study will evaluate primary endpoints such as NIHSS deterioration at 6 weeks post-surgery and overall survival, along with secondary endpoints including progression-free survival and various functional assessments. The study will utilize intraoperative mapping techniques to enhance safety during resection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years and ≤90 years
2. Tumor recurrence according to the RANO criteria of a previously diagnosed glioblastoma based on the WHO 2021 classification for glioma
3. The tumor is suitable for resection (according to neurosurgeon)
4. Written informed consent

Exclusion Criteria:

1. Tumors of the cerebellum, brainstem, or midline
2. Medical reasons precluding MRI (e.g., pacemaker)
3. Inability to give written informed consent
4. Secondary high-grade glioma due to malignant transformation from low-grade glioma
5. Clinical data unavailable for the newly diagnosed setting

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• University Hospital Leuven
  Leuven, Belgium Recruiting
• University Hospital Heidelberg
  Heidelberg, Germany Recruiting
• Erasmus MC
  Rotterdam, South Holland, Netherlands Recruiting
• Medical Center Haaglanden
  The Hague, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Jasper Gerritsen, MD PhD — Erasmus Medical Center
• Study coordinator: Jasper Gerritsen, MD PhD
• Email: j.gerritsen@erasmusmc.nl
• Phone: 31107036130

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Resection techniques for recurrent glioblastoma

  This study is testing different methods of mapping the brain during surgery for recurring glioblastoma to see which one helps patients keep their movement and speech abilities while removing as much of the tumor as possible.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06273176

• Comparing tumor resection and biopsy for high-grade glioma patients

  This study is testing whether removing a brain tumor or just taking a small sample helps older patients with high-grade gliomas live longer and feel better afterward.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146725

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Comparing palliative care and surgery for high-grade glioma patients

  This study is testing whether palliative care or surgery helps people with high-grade glioma live longer and feel better.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146738

• Comparing two surgical approaches for high-grade glioma patients

  This study is testing whether a more extensive surgical method for removing high-grade brain tumors helps patients live longer and feel better compared to a standard approach.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06118723

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.