AI-based precision oncology clinical trial matching and registry

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The SYNERGY Registry is an international observational cohort study aimed at evaluating the feasibility and clinical utility of an Artificial Intelligence-based tool for matching cancer patients to clinical trials. It utilizes a virtual tumor board program and extracts clinical data from electronic health records to dynamically match patients with available clinical trials based on their specific cancer-related biomarkers. The study involves voluntary enrollment of patients with advanced solid and hematological malignancies, and treatment decisions remain at the discretion of their primary providers. The study will assess the impact of this matching tool on clinical trial enrollment and patient outcomes over a period of approximately 36 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pts with solid and hematological malignancies;
* Pts cancer-related biomarkers, gene variants, fusion and rearrangements (by immunohistochemistry, PCR, FISH or NGS): PD-L1, MSI (MMR), Claudin18.2, HER2/Neu, Tumor mutational burden/load (TMB), ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, APC, AR, ATM, ATRX, AURKA, AURKB, BAP1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BTK, CCND1, CCND2, CCND3, CDK4, CDK6, CDKN1A/B, CEBPA, CHEK1, CHEK2, CSF1R, CTNNB1, DAXX, DDR1/2, DNMT3A, EGFR, ERBB2, ERBB3, ERBB4, ERCC4, ER, ESR1, FANCA, FAS, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GATA3, GATA6, GNAS, HDAC1, HGF, HRAS, IDH1, IDH2, IGF1R, JAK1, JAK2, JAK3, KDR (VEGFR2), KIT, KRAS, MAP2K2 (MEK2), MAP3K1, MCL1, MDM2, MDM4, MEN1, MET, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), NF1, NF2, NOTCH1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PARP1, PARP2, PARP3, PBRM1, PDCD1 (PD1), PDCD1LG2 (PD-L2), PDGFRA, PDGFRB, PIK3C, PMS2, POLD1, POLE, PRDM1, PTCH1, PTEN, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA/B/C, SMAD, SMARC, SMO, STK11, TGFBR2, TP53, TSC1, TSC2, VEGFA, VHL, WT1, ZNF217, ZNF703, CEACAM, NRG1, among others.

These biomarkers should be determined by local laboratory, external vendor, or next generation sequencing platform

* Decision to consider clinical trial pre-screening enrollment (CTE) by primary provider and/or patient

Exclusion Criteria:

* ECOG PS \> 2;
* Abnormal organ function;
* Hospice enrollment

Where it's running

• Massive Bio SYNERGY-AI site
  Birmingham, Alabama, United States Recruiting
• Massive Bio SYNERGY-AI site
  Mobile, Alabama, United States Recruiting
• Massive Bio SYNERGY-AI site
  Scottsdale, Arizona, United States Recruiting
• Massive Bio SYNERGY-AI site
  Little Rock, Arkansas, United States Recruiting
• Massive Bio SYNERGY-AI site
  Duarte, California, United States Recruiting
• Massive Bio SYNERGY-AI site
  Irvine, California, United States Recruiting

+18 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: Selin Kurnaz, PhD — Massive Bio, Inc.
• Study coordinator: Fiona Evans, MS
• Email: fevans@massivebio.com
• Phone: +1 (844) 627-7246

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.