Condition

Glioblastoma (GBM) clinical trials and research

• 32Clinical trials
• 2NIH research projects
• 1New in 30 days
• 16Countries

Newest Glioblastoma (GBM) clinical trials

All recruiting trials (32)

• Brain connectome project in adults with brain glioma undergoing surgery

  This registry collects MRI data and clinical information from adults with glioma to see how brain networks relate to surgery and recovery.

  Recruiting Northwell Health · New York, New York · NCT07927595

• Targeted radioligand therapy for recurrent glioblastoma with Lu-177 XT771

  This early-phase study tests whether a radiolabeled medicine (Lu-177 XT771) delivered directly into the tumor cavity is safe and tolerable for adults with recurrent glioblastoma.

  Recruiting at 2 sites Early Phase 1 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07648823

• Personalized Targeted Glioblastoma Therapies Guided by Ex Vivo Drug Screening

  This trial tests whether using a patient’s own tumor cells to screen drugs can guide a personalized treatment plan for people with newly diagnosed glioblastoma undergoing short-course radiotherapy.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT07627334

• LITT for ultra-early GBM recurrence within 1 week of pre-radiation planning

  This study tests whether a minimally invasive laser treatment can destroy an early GBM recurrence without delaying planned radiotherapy and chemotherapy.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07616986

• Combined intracranial and intravenous NK cell therapy for malignant brain tumors

  This trial will test whether giving adults with recurrent malignant brain tumors their own expanded and activated natural killer (NK) cells into the tumor site and into the bloodstream is safe and feasible.

  Recruiting at 3 sites Peking University Third Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07552233

• Preventive intrathecal thiotepa with standard chemoradiation for high‑risk glioblastoma

  This trial tests whether adding six weekly intrathecal injections of thiotepa to standard chemoradiation can lower leptomeningeal spread and improve outcomes for adults with newly diagnosed GBM that contacts the subventricular zone or had ventricular entry during surgery.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07511725

• Local targeted alpha therapy using 225Ac‑DOTA‑SP for newly diagnosed WHO grade 3–4 glioma

  This trial tests a local peptide‑guided alpha‑particle treatment (225Ac‑DOTA‑SP) in adults 18–80 with newly diagnosed WHO grade 3–4 glioma after initial surgery and radiochemotherapy to see if it safely targets residual tumor and improves local control.

  Recruiting at 2 sites Medical University of Warsaw · Warsaw, Poland and 1 other locations · NCT07488754

• BGB-58067 in MTAP-deleted glioblastoma (newly diagnosed)

  This study tests BGB-58067 in adults with newly diagnosed GBM that show MTAP deletion to see how the drug behaves in the body, how it affects tumor biology, and whether it is safe.

  Recruiting Early Phase 1 St. Joseph's Hospital and Medical Center, Phoenix · Phoenix, Arizona · NCT07485049

• MR‑Linac guided adaptive 'dose‑painting' radiation with reduced margins for Grade 4 glioma

  This trial will test whether daily MRI‑guided adaptive 'dose‑painting' radiation with smaller treatment margins helps people with glioblastoma (Grade 4 astrocytoma) get better local tumor control and fewer side effects than standard radiation.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07459101

• Mental health and suicidal thoughts in adults with glioblastoma in Germany

  This project uses questionnaires and medical records to see if depression, anxiety, or other factors are linked to suicidal thoughts or behavior in adults with IDH wild-type glioblastoma.

  Recruiting at 5 sites University Hospital, Essen · Berlin and 5 other locations · NCT07409584

• Music therapy for patients with newly diagnosed GBM after chemoradiation

  This study tests whether adding music therapy helps improve quality of life for adults with newly diagnosed glioblastoma who are receiving standard treatment.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07375992

• GLOW400-assisted neurosurgery for high-grade gliomas

  This PMCF study tests whether the GLOW400 digital fluorescence accessory used with the ARveo8x microscope helps surgeons see tumor tissue during elective surgery for suspected high-grade gliomas.

  Recruiting at 2 sites Leica Microsystems (Schweiz) AG · Porto and 1 other locations · NCT07366892

• AAV dual-payload gene therapy injected directly into high-grade glioma to kill tumor cells and stimulate immune attack.

  This will try TGX-007, a virus-delivered gene therapy given into the tumor together with oral valaciclovir, in adults 18–70 with newly diagnosed or recurrent glioblastoma to see if it safely kills tumor cells and boosts immune response.

  Recruiting at 2 sites Phase 1/2 Trogenix ltd · Columbus, Ohio and 1 other locations · NCT07346144

• Low‑intensity focused ultrasound with EGFR‑targeted T‑cell therapy for newly diagnosed unmethylated glioblastoma

  This trial is testing whether opening the blood–brain barrier with low‑intensity focused ultrasound can help autologous EGFR‑bispecific antibody‑armed T cells reach and treat newly diagnosed MGMT‑unmethylated, IDH‑wildtype glioblastoma.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT07343986

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• B7-H3 targeted antibody-drug conjugate (risvutatug rezetecan) for recurrent Grade 4 glioma and brain metastases

  This study will try risvutatug rezetecan, a B7-H3 antibody-drug conjugate, in adults with recurrent Grade 4 glioma or brain metastases who are undergoing surgical resection.

  Recruiting Early Phase 1 St. Joseph's Hospital and Medical Center, Phoenix · Phoenix, Arizona · NCT07268053

• Stupp treatment plus intrathecal thiotepa for glioblastoma with ventricular or meningeal spread

  This trial will test whether adding intrathecal thiotepa to the Stupp regimen and radiotherapy helps adults with glioblastoma that has spread into the brain ventricles or meninges.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07193654

• MT-125 with radiotherapy for newly diagnosed glioblastoma

  This trial tests whether adding the experimental drug MT-125 to standard radiotherapy helps people with newly diagnosed IDH wild-type, MGMT-unmethylated glioblastoma.

  Recruiting at 3 sites Phase 1/2 Myosin Therapeutics Inc. · Phoenix, Arizona and 2 other locations · NCT07185880

• Injected oncolytic virus for recurrent glioblastoma

  This trial tries an injected oncolytic virus to see if it can shrink or control recurrent glioblastoma in adults.

  Recruiting Phase 1/2 Mianyang Central Hospital · Mianyang, Sichuan · NCT07145047

• Allogeneic γδ T cell therapy for glioblastoma

  This first-in-human trial will try locally delivered, genetically edited allogeneic γδ T cells (ABOUT γδT) to see if they are safe for adults with recurrent or progressive glioblastoma.

  Recruiting at 3 sites Peking University Third Hospital · Beijing, Beijing Municipality and 2 other locations · NCT07144735

• Stem cell–based gene and cell therapy for people with newly diagnosed glioblastoma.

  This trial will test whether an injected stem cell therapy carrying a suicide gene is safe for adults with newly diagnosed glioblastoma after surgery.

  Recruiting Phase 1 CHA University · Seongnam, Kyunggido · NCT07143812

• TLX101-Tx plus standard care versus standard care alone for recurrent glioblastoma

  This test checks whether adding TLX101-Tx, a tumor-targeted radiopharmaceutical given with lomustine, helps adults with first-recurrence glioblastoma control their tumor or live longer compared with lomustine alone.

  Recruiting at 7 sites Phase 3 Telix Pharmaceuticals (Innovations) Pty Limited · Gold Coast, Queensland and 8 other locations · NCT07100730

• FearLess for adults with malignant brain tumors and their caregivers

  This project will test whether the FearLess psychological program can reduce fear of cancer recurrence in adults with primary malignant brain tumors and their nonprofessional caregivers.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT06989086

• Timing of Temozolomide for Glioblastoma Treatment

  This study is testing whether taking the cancer drug temozolomide in the morning or evening helps people with glioblastoma feel better and have fewer side effects.

  Recruiting at 2 sites Ottawa Hospital Research Institute · London, Ontario and 1 other locations · NCT06850766

• Enhanced local intensified radiation for older adults with glioblastoma

  This trial tests whether a higher-dose, short-course (hypofractionated) radiation schedule helps people aged 65 and older with newly diagnosed glioblastoma do better than the standard short-course radiation.

  Recruiting at 3 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 2 other locations · NCT06835803

• Dendritic cell immunotherapy for glioblastoma treatment

  This study is testing if a new dendritic cell immunotherapy, given alongside standard treatments, can help adults newly diagnosed with glioblastoma live longer and feel better.

  Recruiting at 17 sites Phase 2 Diakonos Oncology Corporation · Gilbert, Arizona and 17 other locations · NCT06805305

• Treatment of recurrent glioblastoma with NRG-103 injection

  This study is testing if a new gene therapy called NRG-103 can help adults with recurrent glioblastoma live longer and feel better after receiving two injections.

  Recruiting Early Phase 1 Zhongnan Hospital · Wuhan, Hubei · NCT06757153

• AI blood test using platelet and immune-cell RNA for early cancer detection and monitoring

  This AI-based blood test profiles platelet and immune-cell RNA to see if it can find common cancers early and track treatment response in adults aged 40 and older.

  Recruiting at 2 sites Dysplasia Diagnostics Limited · Rosario and 3 other locations · NCT06717295

• G-CSF after chemo-radiation for MGMT-methylated glioblastoma

  This test checks whether giving G-CSF after standard chemo-radiation helps protect brain structure and thinking in adults with newly diagnosed MGMT-methylated glioblastoma.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06649851

• Intraoperative neuronal recordings during brain tumor surgery

  This study tries out a Neuropixel probe to record brain activity during awake tumor removal in adults with glioma or brain metastases to explore how neurons interact with tumors.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06617208

• Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents

  This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.

  Recruiting Phase 1/2 Fundación de investigación HM · Boadilla del Monte, Madrid · NCT06607692

• Using advanced MRI to tell apart tumor recurrence from false alarms in brain cancer patients

  This study is testing if a new type of MRI can help doctors tell the difference between real tumor growth and false alarms in patients with glioblastoma or brain metastases.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05911230

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted Nanoparticles for Glioblastoma Brain Tumors

  This project is developing tiny, targeted particles to deliver medicine directly to brain tumor cells, aiming to help people with glioblastoma.

  NIH research Nanovalent Pharmaceuticals, INC. · Bozeman, United States · NIH-11145974

• Targeting brain tumors with nanoparticles for treatment

  This study is testing a new kind of tiny particle that can deliver cancer-fighting drugs right to brain tumors, hoping to shrink the tumors and help people with glioblastoma live longer and healthier lives.

  NIH research Nanovalent Pharmaceuticals, INC. · Bozeman, United States · NIH-11081824

Related topics

Quick answers

How many Glioblastoma (GBM) clinical trials are recruiting right now?

32, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (12 trials), China (7 trials), Switzerland (3 trials), Canada (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Early Phase 1: 4, Phase 1/2: 4, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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