Comparing tumor resection and biopsy for high-grade glioma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the effects of maximal tumor resection versus tissue biopsy on survival and quality of life outcomes in high-grade glioma patients aged 70 and older or with limited performance status. It is an international, multicenter, prospective study where patients will be treated with either resection or biopsy in a 3:1 ratio. The primary endpoints include overall survival and the proportion of patients receiving adjuvant treatment, while secondary endpoints focus on neurological morbidity and quality of life assessments post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years and ≤90 years
2. Tumor diagnosed as HGG (WHO grade III/IV) on MRI as assessed by the neurosurgeon
3. Written informed consent

Exclusion Criteria:

1. Tumors of the cerebellum, brainstem or midline
2. Medical reasons precluding MRI (e.g. pacemaker)
3. Inability to give written informed consent
4. Secondary high-grade glioma due to malignant transformation from low-grade glioma
5. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• University Hospital Leuven
  Leuven, Belgium Recruiting
• University Hospital Heidelberg
  Heidelberg, Germany Recruiting
• Erasmus Medical Center
  Rotterdam, South Holland, Netherlands Recruiting
• Haaglanden Medical Center
  The Hague, Netherlands Recruiting

Study contacts

• Principal investigator: Jasper Gerritsen, MD PhD — Erasmus Medical Center
• Study coordinator: Jasper Gerritsen, MD PhD
• Email: j.gerritsen@erasmusmc.nl
• Phone: +31107036130

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing surgery and best treatment for recurrent glioblastoma

  This study is testing whether surgery or the best available treatment helps people with recurring glioblastoma feel better and live longer.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06283927

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Comparing palliative care and surgery for high-grade glioma patients

  This study is testing whether palliative care or surgery helps people with high-grade glioma live longer and feel better.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146738

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Evaluating Bevacizumab with Focused Ultrasound for Recurrent Glioblastoma

  This study is testing if adding focused ultrasound to the standard treatment of Bevacizumab can help people with recurrent glioblastoma feel better and live longer.

  Recruiting at 2 sites Phase 3 NaviFUS Corporation · Taipei and 1 other locations · NCT06496971

• Neoadjuvant radiochemotherapy for glioblastoma treatment

  This study is testing a new combination of radiation and chemotherapy before surgery to see if it helps people with glioblastoma feel better and live longer compared to standard treatment.

  Recruiting Phase 1 Hospital San Carlos, Madrid · Madrid · NCT06418113

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.