Epigenetic rules of brain tumor cell states in glioblastoma
Official title: Epigenetic mechanisms of adaptive plasticity in glioblastoma
Funded at Duke University · NIH-11447009 · Data updated 2026-11-12
This grant studies how glioblastoma cells change states at the epigenetic level to resist therapy, with mouse models and single-cell profiling.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 19, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $726,421 |
| NIH project number | 1R37CA304729-01A1 |
| Project ID | NIH-11447009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with glioblastoma could benefit from future therapies emerging from this research.
✕Less likely to help
Direct benefits are unlikely for patients outside the scope of future translational trials.
What this research studies
Glioblastoma remains one of the deadliest brain cancers despite current treatments. The project focuses on how non-genetic cell states and epigenetic changes drive adaptive therapy resistance. Researchers will use glioma stem cell xenografts in mice and single-cell analyses to map how tumor cells respond to treatment over time. The goal is to translate these insights into strategies that target cell state diversity to improve therapies for GBM patients.
Why it matters
Potential benefit: If successful, the work could lead to new treatment approaches that prevent or overcome therapy resistance in glioblastoma.
How similar studies have gone: Prior work shows epigenetic mechanisms can influence GBM cell states and treatment response, suggesting this approach is promising but not yet proven in humans.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Patel, Anoop P. — Duke University
- Study coordinator: Patel, Anoop P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.