Collecting and preserving glioblastoma tissue during surgery for future research
Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue (PRESERVE GBM)
This study is collecting and saving glioblastoma tumor tissue and blood samples during surgery to help researchers learn more about the disease and find better treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Baptist Health South Florida Academic / other |
| Locations | 1 site (Miami, Florida) |
| Trial ID | NCT05756985 on ClinicalTrials.gov |
What this trial studies
This study aims to collect and preserve glioblastoma tissue during standard tumor resection surgeries, along with blood samples for molecular and genetic testing. Researchers will gather tissue from three different regions of the tumor to analyze variations in structure, DNA, and RNA. The collected data will be compared with imaging results from medical records to enhance understanding of glioblastoma biology. Ultimately, this research seeks to inform the development of new therapies for glioblastoma treatment.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with high-grade glioma on MRI or those with a confirmed diagnosis of glioblastoma or gliosarcoma undergoing repeat tumor resection.
Not a fit: Patients with medical conditions or therapies that could confound study results or are not in their best interest may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved therapies for glioblastoma patients by enhancing our understanding of tumor biology.
How similar studies have performed: While this approach of specimen banking is common, the specific focus on glioblastoma tissue variation and its correlation with imaging data is a novel aspect that has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Have the appearance of high-grade glioma on magnetic resonance (MR) imaging if allowed to consent and will undergo the procedure if the frozen is consistent with glioblastoma or gliosarcoma OR Patients with a history of histologically confirmed diagnosis of World Health Organization Grade glioblastoma or gliosarcoma that are undergoing repeat resection of a recurrent tumor as identified on preoperative MR imaging 2. Aged ≥ 18 years old 3. Contrast-enhancing tumor volume of at least 10 cc on the preoperative, volumetric MRI within 1 month prior to surgery 4. Provision of signed and dated informed consent form by participant or legally authorized representative (LAR), if applicable Exclusion Criteria: 1\. Has a history or current evidence of any medical condition, therapy, or laboratory abnormality that might confound the results of the study or is not in the best interest of the participant, in the opinion of the treating investigator.
Where this trial is running
Miami, Florida
- Miami Cancer Institute at Baptist Health, Inc. — Miami, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Manmeet S Ahluwalia, M.D. — Miami Cancer Institute at Baptist Health, Inc.
- Study coordinator: Manmeet S Ahluwalia, M.D.
- Email: manmeeta@baptisthealth.net
- Phone: (786) 596-2000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.