Condition

Astrocytoma clinical trials and research

• 14Clinical trials
• 7NIH research projects
• 9Countries

Newest Astrocytoma clinical trials

All recruiting trials (14)

• FT536 injection for recurrent WHO Grade 4 astrocytoma

  This will try a single intratumoral dose of FT536, an off-the-shelf engineered NK‑cell therapy, in adults undergoing repeat surgery for recurrent Grade 4 astrocytoma.

  Recruiting Phase 1 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT07560865

• Pre-radiation chemotherapy for high-grade glioma

  Researchers are testing whether giving temozolomide before radiation can help patients with newly diagnosed high-grade gliomas see better outcomes and clearer MRI results after treatment.

  Recruiting Phase 2 Cooper Norcross Health · Camden, New Jersey · NCT07439172

• Tuvusertib for ATRX‑mutated IDH‑mutant astrocytoma

  This trial will test the ATR inhibitor tuvusertib in adults with first‑recurrent IDH‑ and ATRX‑mutant, p53‑mutant astrocytoma to see if it delays tumor progression.

  Recruiting at 9 sites Phase 2 Grupo Español de Investigación en Neurooncología · Palma de Mallorca, Balearic Islands and 9 other locations · NCT07417761

• FearLess for adults with malignant brain tumors and their caregivers

  This project will test whether the FearLess psychological program can reduce fear of cancer recurrence in adults with primary malignant brain tumors and their nonprofessional caregivers.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT06989086

• Understanding brain blood flow and metabolism in patients with brain lesions

  This study is trying to understand how blood flow and metabolism in the brain are affected in patients with brain tumors like glioblastoma, glioma, and astrocytoma.

  Recruiting Erasme University Hospital · Brussels · NCT06797661

• Re-irradiation for recurrent glioblastoma

  This study is testing a new way to safely give radiation treatment again to adults with recurring glioblastoma to see if it can improve their options after their tumors come back.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06344130

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Combining eflornithine and temozolomide for newly diagnosed glioblastoma

  This study is testing a new combination of two medications, eflornithine and temozolomide, to find the best dose for people with newly diagnosed glioblastoma.

  Recruiting at 7 sites Phase 1 Orbus Therapeutics, Inc. · Birmingham, Alabama and 7 other locations · NCT05879367

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Preventing blood clots in outpatients with newly diagnosed grade 4 glioma using apixaban

  This trial will test whether taking apixaban can prevent dangerous blood clots in adults newly diagnosed with grade 4 glioma.

  Recruiting Phase 2 University of Vermont Medical Center · Burlington, Vermont · NCT05683808

• Combining All-Trans Retinoic Acid and PD-1 Inhibition for Recurrent IDH-Mutant Glioma

  This study is testing if a combination of a vitamin A derivative and a cancer immunotherapy can help people with recurrent IDH-mutant glioma feel better and fight their tumors.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05345002

• Proton therapy for brain tumors

  This study is testing whether proton therapy can be a better treatment option for patients with certain brain tumors by comparing it to traditional radiation methods to see if it can reduce harm to healthy tissues.

  Recruiting at 3 sites Maastricht Radiation Oncology · Maastricht, Limburg and 2 other locations · NCT04648462

• Implantable microdevice to test drug effects in primary brain tumors

  A tiny implantable device is placed into your glioma during surgery to see if local releases of standard glioma drugs cause tumor responses.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT04135807

• Using a virus therapy to treat recurrent cerebellar brain tumors in children

  This study is testing a new virus treatment for children with recurring brain tumors to see if it can help them get better when combined with a low dose of radiation.

  Recruiting at 3 sites Phase 1 M.D. Anderson Cancer Center · Birmingham, Alabama and 2 other locations · NCT03911388

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting epigenetic changes in IDH‑mutant, ATRX‑loss adult astrocytoma

  Researchers are working to help the immune system better recognize and attack adult astrocytoma tumors that have IDH mutations and ATRX loss.

  NIH research Hugo W. Moser Res Inst Kennedy Krieger · Baltimore, United States · NIH-11290314

• Advanced brain MRI to understand thinking and memory in low-grade astrocytoma

  This project uses advanced MRI scans to link brain changes with thinking and quality of life in people with lower-grade astrocytoma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11173633

• Targeting tumor metabolism in IDH‑mutant grade 4 astrocytoma

  People with IDH‑mutant grade 4 astrocytoma will get a short presurgery dose of a brain‑penetrant drug that blocks nucleotide metabolism to look for early effects on the tumor.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11164786

• Understanding how certain brain tumors evade the immune system

  This study is looking at how certain brain tumors called astrocytomas, which often affect younger adults, can avoid being attacked by the immune system, and it aims to find new ways to make treatments work better by understanding how these tumors interact with immune cells.

  NIH research Hugo W. Moser Res Inst Kennedy Krieger · Baltimore, United States · NIH-11043440

• Targeting metabolic weaknesses in a type of brain tumor called IDH-mutant astrocytoma.

  This study is looking for new ways to treat a type of brain tumor called IDH-mutant grade 4 astrocytomas by testing a special drug that targets the tumor's unique weaknesses, with the hope of killing the cancer cells while keeping healthy cells safe.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10911187

• Evaluating cognitive function in patients with lower grade astrocytomas using advanced brain imaging techniques.

  This study is looking at how special brain scans can help us understand how lower grade astrocytomas affect thinking and memory in patients, with the hope of finding ways to improve their quality of life and support those who might struggle with cognitive issues.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10910045

• Investigating a new treatment for recurrent brain tumors using a viral vector and a prodrug.

  This study is looking at a new treatment for people with tough brain tumors called glioblastoma or anaplastic astrocytoma, using a special combination of therapies to see if it can help them live longer and fight their tumors better.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10888393

Related topics

Quick answers

How many Astrocytoma clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (11 trials), Netherlands (2 trials), Australia (1 trial), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 5, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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