Blood-brain barrier profiling in high-grade glioma with imaging, biomarkers, and tissue analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study combines advanced MRI, blood biomarkers, neurocognitive testing, and tumor tissue analysis to characterize how the blood-brain barrier changes in glioblastoma. Participants have assessments before surgery, after surgery, and during follow-up after radiotherapy, including serial imaging, blood tests, and cognitive testing. Tumor tissue collected during standard surgical resection will undergo immunohistochemical and transcriptional analyses to relate barrier integrity to tumor biology and function. The goal is to understand how BBB disruption relates to treatment delivery, neurological performance, and clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 years or older.
* Newly diagnosed glioblastoma.
* Selected for surgical tumor resection.
* Able and willing to provide written informed consent.
* Able to undergo study assessments and follow-up procedures.

Exclusion Criteria:

* Contraindication to magnetic resonance imaging.
* Confusion, delirium, or altered state of consciousness that interferes with the ability to provide informed consent.
* Any condition that, in the opinion of the investigator, would prevent completion of study procedures or compromise participant safety.

Where it's running

• Beaumont RCSI Cancer Centre
  Beaumont, Ireland Recruiting

Study contacts

• Study coordinator: Professor Donncha O'Brien, MB, BCh, BAO, MCh, FRCSI (SN)
• Email: cancerdirectorate@beaumont.ie
• Phone: 018093000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.