Condition

Recurrent Glioblastoma clinical trials and research

• 36Clinical trials
• 10NIH research projects
• 8Countries

Newest Recurrent Glioblastoma clinical trials

All recruiting trials (36)

• Targeted radioligand therapy for recurrent glioblastoma with Lu-177 XT771

  This early-phase study tests whether a radiolabeled medicine (Lu-177 XT771) delivered directly into the tumor cavity is safe and tolerable for adults with recurrent glioblastoma.

  Recruiting at 2 sites Early Phase 1 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07648823

• Engineered NK Cells with dual CARs for recurrent glioblastoma

  This study tests whether delivering specially engineered natural killer (NK) cells to glioblastoma patients is safe and helps fight the tumor, using three different administration routes to find the best approach.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT07579208

• Dual-target CAR-NK therapy for adults with recurrent or progressive glioblastoma and other high-grade gliomas

  This study will try giving dual-target CAR-NK cells into the surgical cavity to see if they can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07551336

• Sitagliptin plus bevacizumab for recurrent grade 4 glioma

  This study tests whether adding sitagliptin to bevacizumab can help people whose recurrent glioblastoma or other grade 4 gliomas respond to treatment and to find a safe dose when used with bevacizumab.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07541781

• YSCH-01 alone or with atezolizumab for recurrent glioblastoma

  This will test whether YSCH-01 by itself or together with atezolizumab helps people with recurrent glioblastoma live longer.

  Recruiting Early Phase 1 Huashan Hospital · Shanghai, Shanghai Municipality · NCT07538128

• Dual-target CAR-NK cell therapy for recurrent glioblastoma and high-grade glioma

  This phase 1 study will test whether injecting dual-target CAR-NK cells into the brain is safe and can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07480941

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• AAV dual-payload gene therapy injected directly into high-grade glioma to kill tumor cells and stimulate immune attack.

  This will try TGX-007, a virus-delivered gene therapy given into the tumor together with oral valaciclovir, in adults 18–70 with newly diagnosed or recurrent glioblastoma to see if it safely kills tumor cells and boosts immune response.

  Recruiting at 2 sites Phase 1/2 Trogenix ltd · Columbus, Ohio and 1 other locations · NCT07346144

• Pumitamig with bevacizumab or temozolomide for adults with recurrent glioblastoma

  This test tries pumitamig, an investigational bispecific immunotherapy, alone or with bevacizumab or temozolomide in adults whose glioblastoma has returned after standard radiotherapy and temozolomide.

  Recruiting at 6 sites Phase 2 BioNTech SE · Beijing and 5 other locations · NCT07297212

• Bispecific B7H3/IL13Ra2 armored CAR-T therapy for recurrent or refractory glioblastoma

  This trial will try giving repeated intraventricular injections of EPC-003 bispecific CAR-T cells to adults with B7H3 and/or IL13Ra2 positive recurrent or refractory glioblastoma to see if it is safe and helps control the tumor.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07193628

• Sonodynamic therapy using SONALA-001 or 5-ALA with MRI-guided focused ultrasound for progressive or recurrent glioblastoma

  This trial tries giving SONALA-001 (IV) or 5-ALA (oral) together with MRI-guided focused ultrasound to see if the combination is safe and can help people whose glioblastoma has progressed or come back.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07076472

• Home-based digital platform delivering sequential therapy for people with glioma

  This program will test a mobile app that helps deliver and remotely monitor home-based systemic therapy for adults with newly diagnosed or recurrent glioma.

  Recruiting at 2 sites Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT07074756

• Alpha-emitting seed treatment for recurrent glioblastoma

  This trial will try tiny alpha-emitting seeds placed into the tumor to treat adults with recurrent glioblastoma who are not candidates for surgery.

  Recruiting at 3 sites Alpha Tau Medical LTD. · Scottsdale, Arizona and 2 other locations · NCT06910306

• ACT001 for recurrent glioblastoma with STAT3-high signature

  This study tests ACT001 in adults whose glioblastoma has recurred and shows a high STAT3 signature after standard treatment.

  Recruiting Phase 2 National Neuroscience Institute · Singapore · NCT06894225

• Using genetically modified immune cells to treat recurrent brain tumors

  This study is testing a new treatment using modified immune cells to see if it can help people with recurring brain tumors feel better and fight their cancer.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06815029

• Metabolic profiling of glioblastoma using advanced imaging techniques

  This study is testing new imaging techniques to see how glioblastoma tumors use energy and nutrients, which could help doctors understand the tumors better and improve treatment options.

  Recruiting at 2 sites Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT06613841

• Evaluating BL-B01D1 for patients with recurrent glioblastoma

  This study is testing a new drug called BL-B01D1 to see if it can help people with recurrent glioblastoma who haven't had success with other treatments.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT06598787

• Evaluating a new treatment approach for recurrent glioblastoma

  This study is testing a new combination treatment for adults with recurrent glioblastoma to see if using Optune GIO®, laser therapy, and a drug called pembrolizumab together can help manage their cancer better.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT06558214

• Testing Troriluzole for recurrent glioblastoma treatment

  This study is testing if Troriluzole can help people with recurrent glioblastoma feel better when given before and after surgery compared to just after surgery.

  Recruiting at 3 sites Early Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT06552260

• Re-irradiation for recurrent glioblastoma

  This study is testing a new way to safely give radiation treatment again to adults with recurring glioblastoma to see if it can improve their options after their tumors come back.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06344130

• Comparing surgery and best treatment for recurrent glioblastoma

  This study is testing whether surgery or the best available treatment helps people with recurring glioblastoma feel better and live longer.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06283927

• Resection techniques for recurrent glioblastoma

  This study is testing different methods of mapping the brain during surgery for recurring glioblastoma to see which one helps patients keep their movement and speech abilities while removing as much of the tumor as possible.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06273176

• Combining low-dose radiotherapy with sintilimab and temozolomide for recurrent glioblastoma

  This study is testing a new treatment that combines low-dose radiation with two medications to see if it can help people with recurrent glioblastoma feel better and improve their outcomes.

  Recruiting Phase 2 Fifth Affiliated Hospital, Sun Yat-Sen University · Zhuhai, Guangdong · NCT06220552

• E-SYNC CAR T cell therapy for EGFRvIII positive glioblastoma

  This study is testing a new type of CAR T cell therapy to see if it can help people with a specific type of brain cancer called EGFRvIII positive glioblastoma after they have had chemotherapy.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06186401

• Combining retifanlimab, bevacizumab, and radiation for recurrent glioblastoma treatment

  This study is testing whether a new combination of a drug and radiation can help people with recurring glioblastoma live longer and feel better compared to just using one of the drugs with radiation.

  Recruiting Phase 2 Academic and Community Cancer Research United · Scottsdale, Arizona and 2 other locations · NCT06160206

• Using MRI to understand brain tumor biology in patients with glioblastoma

  This study is testing if MRI scans can help doctors understand brain tumors in patients with glioblastoma to see who might benefit from a specific treatment.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06090903

• Identifying biomarkers for atezolizumab in recurrent glioblastoma

  This study is testing if a new immune therapy called atezolizumab can help people with recurrent glioblastoma who have low levels of tumor mutations.

  Recruiting at 3 sites Phase 2 Duke University · San Francisco, California and 3 other locations · NCT06069726

• Using Trastuzumab Deruxtecan to treat brain cancer

  This study is testing if a new drug called trastuzumab deruxtecan can effectively treat brain cancer in adults with specific types of tumors that have the HER2 protein.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06058988

• Using sonodynamic therapy for recurrent glioblastoma

  This study is testing a new treatment that uses sound waves and a special drug to see if it can safely help people with recurrent glioblastoma by destroying tumor cells while protecting healthy brain tissue.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06039709

• Using CARv3-TEAM-E T Cells to treat glioblastoma

  This study is testing the best dose of a new type of immune cell treatment for people with glioblastoma, a serious brain cancer, to see how safe and effective it is.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT05660369

• Tris-CAR-T Cell Therapy for Recurrent Glioblastoma

  This study is testing a new treatment using modified immune cells to see if it helps people with recurring glioblastoma feel better and fight their cancer.

  Recruiting Phase 1 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05577091

• Evaluating the TheraSphere device for recurrent glioblastoma

  This study is testing a new device that delivers targeted radiation directly to tumors in patients with recurrent glioblastoma to see if it can improve treatment results and reduce side effects.

  Recruiting at 7 sites Phase 1 Boston Scientific Corporation · Birmingham, Alabama and 8 other locations · NCT05303467

• Using advanced MRI and proton therapy to treat recurrent glioblastoma

  This study is testing a new way to treat recurring glioblastoma by using special MRI scans to find hidden cancer cells and then delivering targeted proton therapy along with a medication to help reduce side effects.

  Recruiting University of Miami · Miami, Florida · NCT05284643

• BRiTE: a brain-penetrant bispecific T cell engager for EGFRvIII-positive glioblastoma

  This Phase 1 study tests the safety of BRiTE, a brain-delivered bispecific T cell engager, in adults with newly diagnosed or recurrent EGFRvIII-positive glioblastoma.

  Recruiting Phase 1 Duke University · Durham, North Carolina · NCT04903795

• Treatment for recurrent glioblastoma using Sacituzumab Govitecan

  This study is testing a new treatment called Sacituzumab Govitecan to see if it can help people with recurrent glioblastoma who haven't responded to standard therapies.

  Recruiting at 3 sites Phase 2 The University of Texas Health Science Center at San Antonio · Cleveland, Ohio and 2 other locations · NCT04559230

• Using a modified cold virus to treat recurrent high-grade brain tumors

  This study is testing a new treatment using a modified cold virus delivered through special stem cells to see if it can safely help people with recurring high-grade brain tumors like glioblastoma.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03896568

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Dual-hypoxia and proliferation PET biomarker for recurrent glioblastoma

  A study using a special PET imaging approach to map oxygen-poor areas and cell growth in recurrent brain tumors to guide treatment decisions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11445726

• Sonodynamic therapy for recurrent glioblastoma using MRI-guided focused ultrasound and ALA

  A new treatment combines a drug called 5-ALA with MRI-guided focused ultrasound to target recurrent glioblastoma tumors.

  NIH research Sonalasense INC · San Carlos, UNITED STATES · NIH-11408427

• Targeting Fatty Acid Metabolism to Fight Brain Cancer (GBM)

  A new treatment approach uses a repurposed drug to cut off the energy supply of glioblastoma tumors in the brain.

  NIH research Numiera Therapeutics INC · Denver, United States · NIH-11314195

• Giving immune checkpoint therapy before surgery for recurrent glioblastoma

  This research gives an immune checkpoint drug before surgery to people with recurrent glioblastoma to help the immune system attack the tumor.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11307135

• Decorin and MRI markers to predict response to anti-VEGF treatment in recurrent glioblastoma

  This project looks at whether a protein called decorin and a type of MRI (diffusion MRI) can help predict which people with recurrent glioblastoma will benefit from anti-VEGF therapy like bevacizumab.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11305218

• Using immune therapy before surgery for recurrent glioblastoma

  This study is looking at how giving a special immune therapy before surgery can help patients with recurrent glioblastoma fight their tumors better, and it will compare the results to the usual treatments given after surgery.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11062541

• Investigating how decorin and MRI can improve treatment for recurrent glioblastoma

  This study is looking at how a special protein and MRI scans can help doctors figure out which patients with recurring glioblastoma might benefit the most from a treatment that blocks blood vessel growth in tumors, with the goal of improving outcomes for those patients.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11054702

• Investigating a new treatment for recurrent brain tumors using a viral vector and a prodrug.

  This study is looking at a new treatment for people with tough brain tumors called glioblastoma or anaplastic astrocytoma, using a special combination of therapies to see if it can help them live longer and fight their tumors better.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10888393

• Using ultrasound to improve drug delivery for brain cancer treatment

  This study is testing a new way to help deliver a brain cancer drug more effectively by using ultrasound technology to temporarily open the blood-brain barrier, and it's for patients with recurrent glioblastoma who haven't had success with standard treatments.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10877196

• MRI-guided focused ultrasound with 5‑ALA for recurrent glioblastoma

  This project uses a non-invasive MRI-guided focused ultrasound together with the drug 5‑ALA as a possible treatment for people with recurrent glioblastoma.

  NIH research Sonalasense INC · Oakland, UNITED STATES · NIH-10813104

Related topics

Quick answers

How many Recurrent Glioblastoma clinical trials are recruiting right now?

36, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (26 trials), China (9 trials), Belgium (2 trials), Germany (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 14, Phase 2: 9, Early Phase 1: 5, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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