Role of a brain tumor RNA in glioblastoma where a unique lncRNA may drive cancer cells
Official title: Deciphering the role of the novel long non-coding RNA LINC01896 in glioblastoma multiforme
Funded at University of New Haven · NIH-11516889 · Data updated 2026-11-12
A small, focused NIH grant explores how a brain cancer–related RNA called LINC01896 might control the growth of glioblastoma stem cells and influence treatment resistance.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Haven NIH-funded |
| Lab location | 1 site (West Haven, United States) |
| Project start | March 20, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $69,600 |
| NIH project number | 5R03NS142535-02 |
| Project ID | NIH-11516889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with glioblastoma or patients whose tumors show overexpression of LINC01896 or related molecular features.
✕Less likely to help
Patients without elevated LINC01896 or without glioblastoma may not directly benefit from this research.
What this research studies
This project aims to understand how the long noncoding RNA LINC01896 behaves in glioblastoma stem cells and how its activity supports tumor growth. Researchers will study LINC01896 within the cell nucleus to see how it affects gene regulation and cancer cell survival. The work will use human-derived glioblastoma models and advanced molecular techniques to test what happens when LINC01896 is reduced or altered. Findings could point to new biomarkers or targets for therapies to slow or stop tumor progression.
Why it matters
Potential benefit: If successful, this research could identify new biomarkers and potential therapeutic targets to improve outcomes for glioblastoma patients.
How similar studies have gone: Previous work on cancer-related lncRNAs has shown that similar approaches can reveal functional roles and therapeutic opportunities, though this specific lncRNA is novel in GBM.
Where this research is happening
-
University of New Haven
West Haven, United States Active
Researchers
- Principal investigator: Hazra, Rasmani — University of New Haven
- Study coordinator: Hazra, Rasmani
Related research
Other NIH-funded projects on the same topics.
-
Sonodynamic therapy for recurrent glioblastoma using MRI-guided focused ultrasound and ALA
A new treatment combines a drug called 5-ALA with MRI-guided focused ultrasound to target recurrent glioblastoma tumors.
-
Enhanced delivery of neural stem cells to brain cancer with a biodegradable gel and focused ultrasound
A new treatment approach uses patient-friendly neural stem cells delivered over several months with a biodegradable gel and ultrasound to target glioblastoma.
-
STAG2 mutations and 3D genome organization in glioblastoma
A study in adults with glioblastoma examines how STAG2 gene mutations may change the 3D structure of DNA in tumor cells and drive cancer.
-
Long-lasting stem-cell delivery for glioblastoma using an injectable gel and focused ultrasound
An injectable, biodegradable gel that slowly releases tumor‑killing neural stem cells, paired with focused ultrasound to allow non-surgical re-dosing, for people with glioblastoma.
-
Understanding the STAG2 Gene in Brain Tumors
This project aims to understand how changes in a specific gene called STAG2 contribute to the growth of glioblastoma, a common type of brain tumor.
-
Understanding how metabolic changes help glioblastoma resist radiation treatment
This study is looking at how glioblastoma, a tough type of brain cancer, manages to survive radiation therapy, and it hopes to find new ways to make this treatment work better for patients like you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.