Condition

GBM clinical trials and research

• 18Clinical trials
• 5Countries

Newest GBM clinical trials

All recruiting trials (18)

• Butterfly glioblastoma: test adding 5-ALA PoMA with LIDU ultrasound to standard care

  This early-phase study tests whether adding 5-ALA–mediated activation with LIDU ultrasound is safe and tolerable for adults with newly diagnosed butterfly glioblastoma, before or during standard chemotherapy and radiotherapy.

  Recruiting Phase 1 Alpheus Medical, Inc. · Buffalo, New York · NCT07862647

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• How Acetadote might affect metabolism in newly diagnosed glioblastoma

  This early-phase trial tests whether Acetadote can change brain tumor metabolism in adults with a new glioblastoma diagnosis.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07387666

• Surgery and Laser Therapy for Bilateral Glioblastoma

  This study tests surgery and laser-induced thermal therapy to treat bilateral glioblastoma in people whose tumors cross both brain hemispheres.

  Recruiting King's College Hospital NHS Trust · London · NCT07384884

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• Standard temozolomide plus 5‑ALA and low‑intensity ultrasound after surgery for newly diagnosed glioblastoma

  This trial tests whether adding the light‑activated drug 5‑ALA together with a low‑intensity ultrasound device to standard temozolomide can help people with newly diagnosed glioblastoma after surgery and chemoradiation.

  Recruiting at 11 sites Phase 2 Alpheus Medical, Inc. · Boston, Massachusetts and 10 other locations · NCT07225621

• Focused ultrasound to open the blood-brain barrier in adults with high-grade glioma on chemotherapy

  This trial tests whether focused ultrasound using the Next Generation Dome Helmet can safely open the blood-brain barrier in adults with glioblastoma who are receiving maintenance temozolomide chemotherapy.

  Recruiting Phase 1 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07179328

• Using sonodynamic therapy for recurrent glioblastoma

  This study is testing a new treatment that uses sound waves and a special drug to see if it can safely help people with recurrent glioblastoma by destroying tumor cells while protecting healthy brain tissue.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06039709

• QH104 (allogeneic B7-H3 CAR γδT) for malignant brain glioma

  This study will test if injections of allogeneic B7‑H3 CAR γδT cells (QH104) can help adults with B7‑H3–positive recurrent or progressive high‑grade glioma, including GBM.

  Recruiting Phase 1/2 Dushu Lake Hospital Affiliated to Soochow University · Suzhou, Jiangsu · NCT06018363

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Combining eflornithine and temozolomide for newly diagnosed glioblastoma

  This study is testing a new combination of two medications, eflornithine and temozolomide, to find the best dose for people with newly diagnosed glioblastoma.

  Recruiting at 7 sites Phase 1 Orbus Therapeutics, Inc. · Birmingham, Alabama and 7 other locations · NCT05879367

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Personalized delivery of tumor treating fields for glioblastoma patients

  This study is testing if a new way of mapping brain tumors can help glioblastoma patients using Optune treatment live longer and feel better compared to the standard method.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT05086497

• Evaluating a new immune therapy for glioblastoma patients

  This study is testing a new immune therapy for glioblastoma patients who have had surgery to see if it can help them live longer, especially those with a certain type of immune response.

  Recruiting at 3 sites Phase 2 Ever Supreme Bio Technology Co., Ltd. · Taichung, Non-US and 2 other locations · NCT04115761

• Analysis of glioblastoma multiforme and normal brain tissue

  This study is trying to understand glioblastoma multiforme by comparing the proteins and genes in tumor tissue with those in normal brain tissue to see what makes the cancer different.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT03005132

• Treatment of newly diagnosed glioblastoma using targeted drug infusion

  This study is testing a new way to deliver a targeted drug directly to the brain tumor in people with newly diagnosed glioblastoma to see if it can improve their treatment outcomes.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT02861898

Related topics

Quick answers

How many GBM clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (13 trials), China (2 trials), Canada (1 trial), United Kingdom (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 3, Phase 1/2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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