Glioma adaptive radiotherapy using an AI-driven dose plan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with diffuse gliomas, including glioblastoma, receive standard radiotherapy with MRI and PET imaging up front. During treatment, imaging is repeated to identify resistant areas, and AI helps modify radiation doses to those regions while maintaining safety. The study uses CT, MRI, and PET fusion to drive adaptive dose changes and aims to see if this approach can better target tumor and potentially improve outcomes. Eligible participants are adults 18 to 70 with adequate performance status and a confirmed diffuse glioma.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histological diagnosis of diffuse glioma. Patients with IDH-negative GBM (stratum A) and IDH-mutant glioma (astrocytoma or oligodendroglioma) need radiotherapy (stratum B).

Age: 18-70 years. Karnofsky Performance Scale (KPS) ≥60

Exclusion Criteria:

* Multifocal or multicentric disease Not eligible for radical intent radiation. IDH status is unknown or uninterpretable (IHC or gene sequencing). Use of prior radiotherapy to the head-neck region or brain or chemotherapy. Contraindication/unable to undergo MRI or PET scan during radiation.

Where it's running

• Tata Memorial Hospital
  Mumbai, Maharatshtra, India Recruiting

Study contacts

• Principal investigator: Archya Dasgupta — Tata Memorial Centre
• Study coordinator: Archya Dasgupta
• Email: archya1010@gmail.com
• Phone: 2224177000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.