Condition

Brain Cancer clinical trials and research

• 32Clinical trials
• 38NIH research projects
• 11Countries

Newest Brain Cancer clinical trials

All recruiting trials (32)

• Pilot test of an active surveillance approach for brain metastases during CNS-penetrant systemic therapy

  A small observational study tests whether an active surveillance plan for newly progressing brain metastases during CNS-penetrant systemic therapy is safe for patients.

  Recruiting University of California, Irvine · Orange, California · NCT07827001

• Living Well With Brain Cancer: A Group Program to Support Whole-Person Health

  This program tests a group self-management approach to improve mental and behavioral health for adults with malignant brain tumors.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07628647

• Precision radiotherapy guided by molecular MRI (APT imaging)

  This project will test whether a special MRI scan called amide proton transfer (APT) imaging can better identify the most aggressive areas of glioblastoma to guide radiotherapy in adults.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07512154

• Panitumumab-IRDye800 for guiding brain tumor surgery

  A tiny dose of panitumumab-IRDye800 is tested to see if it helps visualize brain tumors during surgery in adults.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07493447

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery

  This trial tests whether a near-infrared fluorescent version of the immunotherapy drug nivolumab can be given before planned surgery to visualize drug distribution in adults with suspected high-grade glioma.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07210632

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Home-based self-management and cognitive training for brain tumor survivors

  This trial will try a home-based cognitive coaching program to see if it improves thinking and quality of life for adults who survived non-glioblastoma brain tumors, with optional caregiver participation.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06930846

• Combining TIL Therapy and Pembrolizumab for Advanced Brain Cancer

  This study is testing a new treatment that combines a type of immune therapy using patients' own tumor cells with Pembrolizumab to see if it helps people with advanced brain cancer feel better and live longer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06640582

• Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues

  This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06580002

• Using Trastuzumab Deruxtecan to treat brain cancer

  This study is testing if a new drug called trastuzumab deruxtecan can effectively treat brain cancer in adults with specific types of tumors that have the HER2 protein.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06058988

• Evaluating brain metastasis treatment using PET imaging

  This study is testing if a special type of brain scan can help doctors see how well treatment is working for patients with brain tumors caused by cancer.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT06048094

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Evaluating quality of life in cancer patients treated with hadrontherapy

  This study is trying to see how hadrontherapy affects the quality of life for cancer patients with head and neck, skull base, and brain tumors, comparing long-term survivors with those currently receiving treatment.

  Recruiting CNAO National Center of Oncological Hadrontherapy · Pavia, Pv · NCT05947149

• Using advanced imaging to improve brain tumor surgery

  This study is testing a new imaging technique during brain tumor surgery to see if it helps doctors better understand the tumor type and grade, which could lead to better treatment results for patients.

  Recruiting National Taiwan University Hospital · Taipei · NCT05943262

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Using a special imaging agent to evaluate brain metastases after surgery

  This study is testing a special imaging agent to see if it can help doctors find leftover brain tumors after surgery and improve care for patients with brain cancer.

  Recruiting Phase 2 Baptist Health South Florida · Miami, Florida · NCT05554302

• Validation of a blood test for early cancer detection and monitoring

  This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.

  Recruiting at 3 sites Adela, Inc · Duarte, California and 16 other locations · NCT05366881

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Developing a markerless tracking method for real-time tumor motion measurement during radiation therapy

  This study is testing a new way to track tumor movement during radiation therapy without using markers, to see if it can help doctors target the treatment more accurately for cancer patients.

  Recruiting University of Sydney · Saint Leonards, New South Wales and 3 other locations · NCT05184790

• Measuring brain stimulation effects on hand strength in brain tumor patients

  This study tests if brain stimulation during surgery can improve hand strength and function in patients with brain tumors affecting the part of the brain that controls movement.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05023434

• Exploring the impact of anesthesia on brain cancer survival

  This study is testing whether using different types of anesthesia during brain surgery can help improve survival for patients with aggressive brain cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04962672

• Using nanoparticles to enhance radiation treatment for brain metastases

  This study is testing if adding special nanoparticles to radiation therapy can help people with brain metastases get better results than radiation alone.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04899908

• Using 18F-Fluciclovine to Monitor Brain Metastases After Radiation Therapy

  This study is testing a new imaging agent called 18F-fluciclovine to see if it can help track how well radiation therapy is working for people with large brain metastases.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT04689048

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Comparing awake craniotomy and general anesthesia for glioblastoma surgery

  This study is testing whether having brain surgery while awake is safer and more effective than having it under general anesthesia for people with glioblastoma in important areas of the brain.

  Recruiting at 5 sites Erasmus Medical Center · Ghent and 4 other locations · NCT03861299

• Combining capecitabine and temozolomide for newly diagnosed glioblastoma

  This study is testing if combining two cancer drugs, capecitabine and temozolomide, can help people with newly diagnosed glioblastoma live longer and feel better compared to using temozolomide alone.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT03213002

• Treatment of newly diagnosed glioblastoma using targeted drug infusion

  This study is testing a new way to deliver a targeted drug directly to the brain tumor in people with newly diagnosed glioblastoma to see if it can improve their treatment outcomes.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT02861898

• Targeting brain tumors with a specific drug infusion and re-irradiation

  This study is testing a new way to deliver a drug directly to brain tumors in patients with certain aggressive types of glioblastoma to see if it can improve treatment results.

  Recruiting Phase 2 Northwell Health · New York, New York · NCT02800486

• Using advanced MRI to identify high-risk areas in brain tumors for radiation planning

  This study is testing if advanced MRI can help doctors find the most dangerous parts of brain tumors to plan better radiation treatment for patients with malignant gliomas.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT00870129

NIH-funded research (38)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Social connections and quality of life for kids who survived brain cancer

  This project follows pediatric brain cancer survivors as they grow into adults to understand how their social connections affect their happiness and mental well-being.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11473996

• Brain cancer and brain-glia communication: how tumor cells and microglia talk to each other to drive gbm growth

  A patient-facing look at how GBM tumors may manipulate brain immune cells to grow, and how understanding this communication could lead to new treatments.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11448832

• Clarified imaging reports to reduce anxiety for adult survivors of pediatric brain cancer

  Adult survivors of pediatric brain cancer may get anxious about scan results, and clearer imaging reports delivered through patient portals could help reduce worry and improve understanding.

  NIH research Washington University · Saint Louis, United States · NIH-11435742

• MRI-guided brain tumor surgery robot to improve laser ablation

  A new MRI-compatible robotic system helps precise, real-time laser treatment for brain tumors inside the MRI suite.

  NIH research Aim Medical Robotics INC · Worcester, United States · NIH-11407571

• Brain cancer therapies to help kids and adults with glioblastoma and medulloblastoma

  A large NIH grant supports translating promising brain cancer therapies from the lab into patient trials to help people with glioblastoma and medulloblastoma.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11404894

• Brain cancer: Translational approaches to improve outcomes for glioblastoma patients

  A team at Northwestern is working on better ways to treat glioblastoma, the deadliest brain cancer, with a focus on translating discoveries into real therapies.

  NIH research Northwestern University · Chicago, United States · NIH-11402755

• Polymeric micelles delivering nose-to-brain imaging for brain cancer surgery

  Aims to help brain cancer patients by giving surgeons real-time, nose-delivered imaging that highlights cancer tissue during brain tumor surgery.

  NIH research Fairleigh Dickinson University · Teaneck, United States · NIH-11396363

• New ways to treat HER2-positive brain metastases

  A research team at Northwestern is testing new ways to get anti-HER2 therapies into brain tumors by using engineered stem cells to deliver trastuzumab-like medicines directly to brain metastases from breast cancer.

  NIH research Northwestern University · Chicago, United States · NIH-11384500

• Automated brain MRS to improve cancer imaging

  A research project aims to make brain tumor magnetic resonance spectroscopy faster, more reliable, and easier to use by automating real-time measurements and providing open-source tools.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11380557

• UCLA brain cancer SPORE: new immunotherapy and cell-death strategies

  A premier, patient-focused program at UCLA aims to improve brain cancer diagnosis, prognosis, and treatment by combining immunotherapy, smarter drug strategies, and CAR-T approaches to overcome treatment resistance.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11377152

• Next-Gen Brain Cancer Surveillance with Wireless Miniature Imaging

  A Johns Hopkins-led project will develop a wireless, multi-contrast brain imaging tool to watch glioblastoma cells, tumor signals, and blood vessels move together in living animal models, with the goal of understanding how these cancers spread.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11367355

• Context-specific pathway dependencies for nuclear envelope proteins in brain cancer

  This grant explores how nuclear envelope proteins influence brain cancer behavior using cancer cell models to map signaling and functional networks.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11366260

• Multi-parametric perfusion MRI to predict brain cancer therapy response

  A study to improve brain cancer care by using advanced MRI techniques to predict early how tumors respond to treatment.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-11361637

• How immune cells in glioblastoma are controlled by metabolism

  Researchers are testing ways to change immune cells inside glioblastoma tumors so treatments work better for people with GBM.

  NIH research Wistar Institute · Philadelphia, United States · NIH-11309175

• Targeting mechanical signaling in childhood brain tumors

  Looking for drugs that block how tumor cells sense and respond to their surroundings to help children with medulloblastoma.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11264778

• 3D-printed scaffolds to help tumor-seeking stem cells prevent brain tumor return after surgery

  This work uses custom 3D-printed scaffolds to help tumor-homing stem cells stay in the surgical cavity and deliver cancer-fighting therapy to people with glioblastoma after tumor removal.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11263704

• Better MRI Scans for Brain Cancer Treatment

  This project aims to make MRI scans more accurate at showing how well brain cancer treatments are working for patients.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-11249956

• UCLA program developing new treatments for brain tumors

  This program will combine immune-based therapies and engineered CAR-T cells to try to help people with aggressive brain tumors like glioblastoma.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11210549

• Understanding how immune cells affect brain cancer treatment

  This study is looking at how certain immune cells in the brain, called macrophages, behave in glioblastoma, a tough type of brain cancer, to find new ways to make treatments work better for patients.

  NIH research Wistar Institute · Philadelphia, United States · NIH-11194004

• New approaches for glioblastoma and medulloblastoma

  This program tests multiple new treatment approaches for people with glioblastoma (an adult brain tumor) and medulloblastoma (a childhood brain tumor).

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11193437

• Translating new treatments for brain tumors

  This program brings doctors and researchers together to create and test new treatment options for people with glioblastoma and other brain tumors.

  NIH research Northwestern University · Chicago, United States · NIH-11187066

• Automated MRI spectroscopy for clearer brain tumor metabolic scans

  This project will build automated MRI tools that help doctors get reliable metabolic scans of brain tumors for adults during routine MRI appointments.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11177633

• UCLA Brain Cancer Research

  This research at UCLA aims to find better ways to diagnose, predict, and treat brain cancer, especially by overcoming how tumors resist current therapies.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11164726

• New approaches to treat HER2-positive breast cancer that has spread to the brain

  Using engineered neural stem cells to carry HER2-targeted antibody drugs directly into the brain to treat HER2-positive breast cancer metastases.

  NIH research Northwestern University · Chicago, United States · NIH-11159806

• Nose-delivered glowing marker to guide brain tumor surgery

  This project is testing a nose-delivered fluorescent agent that lights up brain tumors so surgeons can see and remove them more accurately in adults with brain cancer.

  NIH research St. John's University · Queens, United States · NIH-11138754

• Understanding Social Connections for Childhood Brain Tumor Survivors

  This project looks at how social connections affect the health and happiness of adults who survived brain tumors as children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11129613

• New treatment approach for pediatric brain cancer

  This study is exploring a new way to treat glioblastoma, a tough brain cancer in kids, by targeting the stubborn cancer cells while protecting healthy brain tissue, so that young patients can get better care with fewer side effects.

  NIH research Stanford University · Stanford, United States · NIH-11032856

• Targeting mechanosignaling to improve treatments for pediatric brain cancer

  This study is working on finding better treatments for kids with brain cancer, especially medulloblastoma, by using special 3D models that closely resemble how tumors grow in the body, which helps researchers discover new medicines that could improve care for young patients.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11032821

• Improving stem cell therapy for brain cancer using 3D printing

  This study is exploring how to make brain cancer treatment better by using special 3D-printed structures that help deliver healing stem cells right to the tumor site after surgery, aiming to improve recovery for patients with glioblastoma.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11011262

• Creating a new treatment to eliminate brain cancer and its spread.

  This study is testing a new treatment for brain cancer that aims to help patients, both adults and kids, who haven't had success with current therapies by targeting specific pathways in their tumors.

  NIH research Creative Biotherapeutics, LLC · Gurnee, United States · NIH-11007080

• Understanding how specific immune receptors affect brain cancer growth

  This study is looking at how two immune receptors, Trem1 and Trem2, affect the body's immune response to glioblastoma, a tough type of brain cancer, and it aims to find new ways to help patients by understanding how these receptors influence tumor growth and treatment resistance.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10999313

• Improving MRI techniques to assess brain cancer treatment response

  This study is working to make MRI scans better at showing how well treatments for brain cancer are working, so patients can get quicker and more accurate answers without needing more invasive tests like biopsies.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-10996225

• New treatments for metastatic brain cancer from breast cancer

  This study is looking for better ways to treat brain tumors that come from breast cancer, especially for women with HER2+ breast cancer, by understanding how these cancer cells spread to the brain and finding new ways to deliver targeted treatments directly to them.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10976291

• Using special nanoparticles to improve brain cancer surgery through the nose.

  This study is looking at a new way to help brain cancer surgeons find tumors more easily during surgery by using special tiny carriers that deliver imaging agents through the nose, which could lead to safer and more effective surgeries for patients.

  NIH research St. John's University · Queens, United States · NIH-10935078

• Creating tools to improve brain cancer diagnosis using advanced imaging techniques

  This study is working on new tools that make it easier for doctors to use MRI scans to learn more about brain tumors, helping them understand the tumors better and see how well treatments are working, all without needing any special training.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10926909

• Automating brain cancer imaging for better diagnosis

  This study is working on new ways to use MRI technology to better understand brain tumors by making it easier and quicker to get important information about them, so doctors can help patients more effectively without needing a lot of specialized training.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10925156

• Improving treatments for brain cancer patients

  This study is looking for better ways to treat brain tumors, especially glioblastoma, by bringing together a team of experts to find new treatment options that could help patients like you.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10898565

• Understanding social connections in young brain cancer survivors

  This study looks at how having friends and social support affects the health and happiness of kids who have survived brain cancer, and it aims to find out what makes it hard for them to connect with others, so we can help improve their social lives and well-being.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10750950

Related topics

Quick answers

How many Brain Cancer clinical trials are recruiting right now?

32, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (26 trials), Belgium (2 trials), Netherlands (2 trials), Australia (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 4, Phase 1: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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