Using microdialysis during brain surgery to collect biomarkers for tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the feasibility of using microdialysis catheters during neurosurgery to collect extracellular metabolites from patients with central nervous system malignancies, such as gliomas and metastatic brain tumors. The primary objective is to identify biomarkers that can help differentiate between tumor types and assess tumor-associated processes. Patients will undergo microdialysis for 30 minutes during their standard surgical procedure, and the information gathered may lead to improved diagnostic and treatment strategies for brain tumors. Follow-up will occur for 42 days post-procedure to monitor outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 18 years
* Diagnosis of the following, based on clinical and radiographic evidence:

  * Any glioma
  * Metastatic brain tumor of any primary origin
  * Epileptic focus requiring surgical resection
* Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care
* Willing to undergo neurosurgical resection or biopsy at Mayo Clinic \[Rochester, Minnesota (MN)\]
* For patients with gliomas recruited for post-operative microdialysis, willingness to stay in the hospital through post-operative day (POD) 3-5 (timing per physician and patient's shared decision making)
* Ability to understand and the willingness to sign a written informed consent document
* Enrollment into the Biobank study (IRB#12-003458)

Exclusion Criteria:

* Vulnerable populations: pregnant women, prisoners or the mentally handicapped
* Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Terence C Burns, MD, PhD — Mayo Clinic in Rochester
• Study coordinator: Clinical Trials Referral Office
• Email: mayocliniccancerstudies@mayo.edu
• Phone: 855-776-0015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.