Condition

High Grade Gliomas clinical trials and research

• 13Clinical trials
• 9NIH research projects
• 8Countries

Newest High Grade Gliomas clinical trials

All recruiting trials (13)

• Preoperative Proton Therapy for High-Grade Brain Tumors

  This trial tests whether giving proton therapy before surgery is tolerable for people with high-grade brain gliomas.

  Recruiting Phase 1 National Medical Research Radiological Centre of the Ministry of Health of Russia · Obninsk, Kaluga Oblast · NCT07710040

• Neuro-navigation-guided focused ultrasound with nivolumab for relapsed or progressive high-grade brain tumors in children

  This study tests whether using focused ultrasound to open the blood-brain barrier and give nivolumab is safe and feasible for kids with relapsed or progressive DMG/DIPG or other high-grade brain tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07664176

• G207 with 5 Gy Radiation for pediatric high-grade glioma

  This study tests whether injecting G207 into a brain tumor plus a single 5 Gy radiation dose is safe and could help extend survival for children with recurrent or progressive high-grade gliomas.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07649070

• Dual-target CAR-NK therapy for adults with recurrent or progressive glioblastoma and other high-grade gliomas

  This study will try giving dual-target CAR-NK cells into the surgical cavity to see if they can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07551336

• Pre-radiation chemotherapy for high-grade glioma

  Researchers are testing whether giving temozolomide before radiation can help patients with newly diagnosed high-grade gliomas see better outcomes and clearer MRI results after treatment.

  Recruiting Phase 2 Cooper Norcross Health · Camden, New Jersey · NCT07439172

• AAV dual-payload gene therapy injected directly into high-grade glioma to kill tumor cells and stimulate immune attack.

  This will try TGX-007, a virus-delivered gene therapy given into the tumor together with oral valaciclovir, in adults 18–70 with newly diagnosed or recurrent glioblastoma to see if it safely kills tumor cells and boosts immune response.

  Recruiting at 2 sites Phase 1/2 Trogenix ltd · Columbus, Ohio and 1 other locations · NCT07346144

• Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery

  This trial tests whether a near-infrared fluorescent version of the immunotherapy drug nivolumab can be given before planned surgery to visualize drug distribution in adults with suspected high-grade glioma.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07210632

• Determine the highest tolerated dose and safety of Rhenium-186 Nanoliposome in children with recurrent ependymoma or high-grade glioma

  This study tests whether 186RNL can be given safely to children and teens with recurrent ependymoma or high-grade glioma to find a safe dose for future study.

  Recruiting Phase 1 Cerenome · Chicago, Illinois · NCT07061626

• TP53 gene therapy (SGT-53) with nivolumab and focused radiation for children with recurrent brain tumors

  This study tests a TP53 gene therapy called SGT-53 combined with the immune drug nivolumab and focused radiation in children whose brain tumors have come back, grown, or not responded to prior treatment.

  Recruiting Early Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07017816

• Local targeted therapy for recurrent glioblastoma using alpha emitter.

  This study is testing a new targeted treatment for adults with recurrent high-grade gliomas to see if it can help them after standard therapies have failed.

  Recruiting at 2 sites Medical University of Warsaw · Warsaw, Poland and 1 other locations · NCT06975332

• Using tissue monitoring to improve surgery for brain tumors

  This study is testing a new tool that helps surgeons find and remove brain tumor tissue more effectively during surgery for patients with high-grade gliomas.

  Recruiting at 2 sites Kuopio University Hospital · Kuopio, Northern Savonia and 2 other locations · NCT06740097

• Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents

  This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.

  Recruiting Phase 1/2 Fundación de investigación HM · Boadilla del Monte, Madrid · NCT06607692

• QH104 (allogeneic B7-H3 CAR γδT) for malignant brain glioma

  This study will test if injections of allogeneic B7‑H3 CAR γδT cells (QH104) can help adults with B7‑H3–positive recurrent or progressive high‑grade glioma, including GBM.

  Recruiting Phase 1/2 Dushu Lake Hospital Affiliated to Soochow University · Suzhou, Jiangsu · NCT06018363

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• MT-125: a brain-penetrant treatment to slow glioblastoma spread and growth

  A new drug, MT-125, taken by people with recurrent glioblastoma, targets two motor proteins to slow cancer spread and growth inside the brain.

  NIH research Myosin Therapeutics INC. · Jupiter, United States · NIH-11387631

• How immune myeloid cells affect aggressive childhood brain tumors

  Researchers are looking at whether immune cells called macrophages and neutrophils inside and around aggressive childhood brain tumors are linked to tumor behavior and survival in children with high-grade gliomas.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11357817

• MT-125 treatment for recurrent high-grade brain tumors

  Adults with recurrent high-grade gliomas will receive the brain-penetrant drug MT-125 to find safe doses and check whether it can slow tumor invasion and growth.

  NIH research Myosin Therapeutics INC. · Jupiter, United States · NIH-11174970

• Investigating the role of immune cells in childhood brain tumors

  This study is looking at how certain immune cells in the brain, called macrophages and neutrophils, affect a type of brain cancer in kids, and it hopes to find new ways to help treat these young patients better.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11099934

• Understanding how a specific histone mutation affects brain tumor development in children

  This study is looking at how a specific change in a gene related to brain development might lead to brain tumors in kids, with the hope that understanding this could help find better treatments for these tough-to-treat tumors.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11097333

• Developing mRNA therapies for a deadly pediatric brain tumor

  This study is exploring a new way to treat a tough brain tumor called diffuse midline glioma in kids by using special particles to deliver gene therapy directly to the tumor, aiming to improve how we fight this disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10947149

• Using oncolytic viruses to deliver genes for treating high-grade gliomas

  This study is exploring a new way to treat aggressive brain tumors in kids by using special viruses that can target and destroy cancer cells, while also boosting the body's immune system to help fight the cancer better, and some patients may have the chance to try these exciting new treatments in clinical trials.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10832350

• Creating human brain models to study aggressive brain tumors in children

  This study is working on creating mini brain models from children's cells to learn more about aggressive brain tumors called pediatric high-grade gliomas, so we can find better treatments that actually help kids.

  NIH research Emory University · Atlanta, United States · NIH-10727450

• Using a modified herpes virus to treat brain tumors in children

  This study is testing a special virus treatment for kids aged 3-18 with tough brain tumors, hoping to see if it can help them live longer and feel better when combined with radiation therapy.

  NIH research Treovir, INC · Birmingham, UNITED STATES · NIH-10244948

Related topics

Quick answers

How many High Grade Gliomas clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (7 trials), China (2 trials), Russia (1 trial), Poland (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 1/2: 3, Early Phase 1: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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