Comparing palliative care and surgery for high-grade glioma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of palliative care versus biopsy and resection on survival and quality of life in patients with high-grade glioma. It is an international, multicenter, prospective observational study that treats patients in a 1:3:3 ratio across three arms. The primary objectives include measuring overall survival and quality of life at multiple time points using standardized questionnaires. The study aims to identify which subset of patients may benefit most from surgical intervention versus palliative care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years and ≤90 years
2. Tumor diagnosed as HGG (WHO grade III/IV) on MRI as assessed by the neurosurgeon
3. Written informed consent

Exclusion Criteria:

1. Tumors of the cerebellum, brainstem or midline
2. Inability to give written informed consent
3. Secondary high-grade glioma due to malignant transformation from low-grade glioma
4. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• University Hospital Leuven
  Leuven, Belgium Recruiting
• University Hospital Heidelberg
  Heidelberg, Germany Recruiting
• Erasmus Medical Center
  Rotterdam, South Holland, Netherlands Recruiting
• Haaglanden Medical Centre
  The Hague, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Jasper Gerritsen, MD PhD — Erasmus Medical Center
• Study coordinator: Jasper Gerritsen, MD PhD
• Email: j.gerritsen@erasmusmc.nl
• Phone: 31107036130

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.