Understanding brain blood flow and metabolism in patients with brain lesions
Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.
NA · Erasme University Hospital · NCT06797661
This study is trying to understand how blood flow and metabolism in the brain are affected in patients with brain tumors like glioblastoma, glioma, and astrocytoma.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Erasme University Hospital (other) |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Brussels) |
| Trial ID | NCT06797661 on ClinicalTrials.gov |
What this trial studies
This research investigates neurovascular uncoupling (NVU) in patients with brain lesions, particularly focusing on glioblastoma, glioma, and astrocytoma. Using a multimodal noninvasive imaging approach, including functional MRI and PET scans, the study aims to explore the mechanisms behind the relationship between brain metabolism, blood flow, and neuronal activity. By analyzing these interactions, the study seeks to improve the understanding of brain function in the context of brain tumors and their treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with a potentially resectable intra-cerebral mass lesion who have not yet undergone surgery, chemotherapy, or radiation.
Not a fit: Patients with previous brain surgery, respiratory failure, asthma, claustrophobia, or diabetes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy of brain imaging techniques, leading to better surgical outcomes for patients with brain tumors.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown promise in understanding neurovascular coupling and its implications for brain imaging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation Exclusion Criteria: * previous brain surgery * respiratory failure * Asthma * Claustrophobia * Previous adverse reaction to gadovist (contrast agent) * Pregnancy and Breath feeding * Diabetes (type I and II)
Where this trial is running
Brussels
- HUB-Erasme Hospital — Brussels, Belgium (RECRUITING)
Study contacts
- Study coordinator: Thibault Vanbutsele
- Email: thibault.vanbutsele@hubruxelles.be
- Phone: 25558167
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glioblastoma, Glioma, Astrocytoma, Primary brain tumor