Clinical trial Recruiting at 1 site Observational Ages 18 to 75

Comparing eccentric and traditional exercise on fatigue in multiple sclerosis

Official title: The Effect of Lower Extremity Eccentric Resistance Training on Fatigue in Multiple Sclerosis

Run by Hunter College of City University of New York · NCT06505421 · Data updated 2026-11-12

This study is testing whether eccentric exercise is better than traditional exercise for reducing fatigue in people with multiple sclerosis.

Quick facts

Study typeObservational
Ages18 Years to 75 Years
SexAll
Enrollment30 (estimated)
SponsorHunter College of City University of New York
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedJuly 1, 2024
Main results expectedDecember 30, 2025
Study endsDecember 30, 2026
Registry record updatedJuly 17, 2024
Trial IDNCT06505421 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with a definitive diagnosis of multiple sclerosis who can walk for six minutes continuously.

Probably not a fit

Patients who have experienced a recent exacerbation of MS or have other orthopedic or cardiopulmonary conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the effects of eccentric resistance training versus traditional resistance training on fatigue levels in individuals with multiple sclerosis (MS). Participants will engage in two different training sessions over two weeks, with one week dedicated to each type of training. After each session, fatigue levels will be assessed to determine any differences between the two training methods. The study seeks to understand if eccentric training, which may be less fatiguing, could be a viable option for improving mobility in MS patients.

Why it matters

Potential benefit: If successful, this study could provide insights into more effective exercise regimens for managing fatigue in patients with multiple sclerosis.

How similar studies have gone: While eccentric training has shown promise in other populations, this specific comparison in MS is novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Definitive diagnosis of Multiple Sclerosis.
* Ability to walk for 6 minutes continuously with or without assistive device
* Ability read, understand and sign and informed consent

Exclusion Criteria:

* Evidence of recent exacerbation in the last 2 months prior to starting the study
* Orthopedic, cardiopulmonary, or non -MS neurologic condition that could interfere with carrying out the study protocol

Where it's running

  • Hunter College, Physical Therapy Department, City University of New York
    New York, New York, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.