Understanding how fatigue affects effort perception in decision-making

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the behavioral and neural mechanisms behind how individuals perceive the effort required for tasks, particularly in the context of fatigue and motivation. By using a combination of experiments with healthy participants, computational modeling, and functional magnetic resonance imaging (fMRI), the research will identify the brain regions involved in valuing physical and cognitive effort. The study seeks to uncover both common and distinct neural circuits that represent effort valuation, which could provide insights into motivated performance in mental disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Right-handed
* Age between 18 and 35 years old - Male or female
* Any ethnicity

Exclusion Criteria:

Individuals with a history of any of the following will be excluded from the study:

* Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report)
* Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report)
* Metal in the head or eyes
* If they are pregnant or suspect that you may be pregnant
* If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos

Where it's running

• Kennedy Krieger Institute
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Vikram S. Chib, PhD — Kennedy Krieger Institute and Johns Hopkins School of Medicine
• Study coordinator: Anthony Gonzalez
• Email: gonzalezan@kennedykrieger.org
• Phone: 443-923-2716

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.