Understanding how fatigue affects effort perception in decision-making
Behavioral and Neural Representations of Subjective Effort Cost
NA · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · NCT04041154
This study is trying to see how feeling tired affects how people judge the effort needed for tasks, especially to help understand motivation in mental health issues.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 185 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (other) |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT04041154 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the behavioral and neural mechanisms behind how individuals perceive the effort required for tasks, particularly in the context of fatigue and motivation. By using a combination of experiments with healthy participants, computational modeling, and functional magnetic resonance imaging (fMRI), the research will identify the brain regions involved in valuing physical and cognitive effort. The study seeks to uncover both common and distinct neural circuits that represent effort valuation, which could provide insights into motivated performance in mental disorders.
Who should consider this trial
Good fit: Ideal candidates for this study are right-handed individuals aged 18 to 35, regardless of ethnicity.
Not a fit: Patients with neurological issues, severe psychiatric diseases, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of motivation and effort perception, potentially leading to better interventions for individuals with fatigue-related conditions.
How similar studies have performed: While the specific approach of this study may be novel, related research has indicated the importance of understanding effort valuation in mental health contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Right-handed * Age between 18 and 35 years old - Male or female * Any ethnicity Exclusion Criteria: Individuals with a history of any of the following will be excluded from the study: * Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report) * Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report) * Metal in the head or eyes * If they are pregnant or suspect that you may be pregnant * If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos
Where this trial is running
Baltimore, Maryland
- Kennedy Krieger Institute — Baltimore, Maryland, United States (RECRUITING)
Study contacts
- Principal investigator: Vikram S. Chib, PhD — Kennedy Krieger Institute and Johns Hopkins School of Medicine
- Study coordinator: Anthony Gonzalez
- Email: gonzalezan@kennedykrieger.org
- Phone: 443-923-2716
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Fatigue