Using advanced MRI to study brain changes in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a new clinical neuroimaging tool that utilizes advanced MRI technologies to assess microstructural changes in the brains of stroke and transient ischemic attack (TIA) patients. By focusing on the connections in the brain that may be affected by these conditions, the study seeks to provide insights into the underlying causes of fatigue experienced by these patients. Participants will undergo clinical assessments and MRI scans to evaluate their brain microstructures and the potential impact of ischemic injuries. The findings could lead to improved understanding and management of post-stroke fatigue.

Why it matters

Who can join: the full rules

Patient Inclusion Criteria:

* Stroke or TIA (ABCD2\>4 and/or acute Diffusion-Weighted Image (DWI) lesion).
* Modified Rankin Scale \<=2.
* As perceived by the investigator, have the ability to comply with all requirements of the study protocol.
* Have the ability to understand and sign the Informed Consents Form.
* Multidimensional Fatigue Inventory score \>= 12 on general fatigue.

Patient Exclusion Criteria:

* The DRCMR´s general exclusion criteria for MRI research.
* Pregnancy or lactation; human chorionic gonadotropin (hCG) urine test is offered for women \< 55 years.
* Major medical illness (for instance: anemia, diabetes mellitus, thyroid disorders, cardiovascular disease, electrolyte imbalance, etc.)
* Treated with ritalin or modafinil.
* Known uncontrolled severe malignancy.
* Known drug or alcohol addiction.
* Tiredness due to pharmaceutical side effects, as identified by the Investigator.
* Max body weight of 130 kg.
* Persons who do not wish to be informed about abnormal findings as part of the investigations.

Healthy Controls Exclusion Criteria:

* The DRCMR´s general exclusion criteria for MRI research.
* Pregnancy or lactation; urin hCG test is offered for women \< 55 years.
* Major medical illness (for instance: anemia, diabetes mellitus, thyroid disorders, cardiovascular disease, electrolyte imbalance, etc.)
* Anamnestic infection (cystitis, influenza, pneumonia, etc) the last 3 weeks.
* Known malignancy.
* Known drug or alcohol addiction.
* Tiredness due to pharmaceutical side effects.
* Max body weight of 130 kg.
* Persons who do not wish to be informed about abnormal findings as part of the investigations.

Healthy Controls Inclusion Criteria:

* Healthy
* Age- and sex-matched to patient groups.
* As perceived by the investigator, have the ability to comply with all requirements of the study protocol.
* Have the ability to understand and sign the Informed Consents Form.

Where it's running

• Bispebjerg Hospital
  Copenhagen, København NV, Denmark Recruiting
• Danish Research Centre for Magnetic Resonance
  Copenhagen, Denmark Recruiting

Study contacts

• Principal investigator: Tim B. Dyrby, Professor — Danish Research Centre for Magnetic Resonance
• Study coordinator: Maria del Carmen Moreno Genis, MSc
• Email: carmenmg@drcmr.dk
• Phone: 38626446

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Remote Ischaemic Conditioning for Fatigue After Stroke 2

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• Music therapy after stroke

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• Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.