RISE‑YA tele‑exercise to reduce fatigue in young adult brain tumor survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program delivers a supervised tele‑exercise intervention (RISE‑YA) alongside survivorship education for fatigued young adult brain tumor survivors. The primary outcome is change in cancer‑related fatigue measured by the FACIT‑Fatigue scale, with secondary outcomes including physical activity, physical function, and biomarkers of oxidative phosphorylation and inflammation. Exploratory outcomes include quality of life, muscle mass measures, dietary intake, and exercise adherence and progression. Participants are aged 18–39, 6 months to under 5 years after curative treatment, and must have received chemotherapy and radiation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Is currently between the ages of 18-39 years
2. Their primary brain tumor was diagnosed at age 15-39 years
3. Is 6 months to \<5 years post curative treatment
4. Has been treated with chemotherapy and radiation, given most patients receive both therapies.
5. Functional Assessment of Chronic Illness therapy (FACIT)-Fatigue ≤ 43. FACIT-Fatigue will be used as a screener because this 13-item scale can be completed relatively quickly in clinic
6. Currently engage in \<150 minutes of PA and \< 2 sessions of muscle strengthening exercise per week (assessed by Godin Leisure-Time PA Questionnaire)
7. Must be able to speak, write, and read English
8. No exercise contraindication as assessed by screening with the Physical Activity Readiness Questionnaire PAR-Q+. In addition, participants' care teams will be notified of their participation in the study.
9. Must be able to provide informed consent/assent.

Exclusion Criteria:

1. Non-English speaking
2. Screen failure for exercise safety
3. Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
4. Recent fracture or acute musculoskeletal injury that precludes ability to participate in supervised exercise training sessions
5. History of underlying chronic disease, secondary malignances, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain
6. Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.
7. Self-report of pregnancy
8. Prisoners
9. Documented developmental disorders (e.g., Autism) or major psychotic illness (e.g., schizophrenia)

Where it's running

• The University of Texas M. D. Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Michael Roth, MD — M.D. Anderson Cancer Center
• Study coordinator: Michael Roth, MD
• Email: mroth1@mdanderson.org
• Phone: (713) 792-7751

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.