Long COVID as a possible subtype of chronic fatigue syndrome
Official title: Long COVID as a putative subtype of chronic fatigue syndrome
Funded at Massachusetts General Hospital · NIH-11391125 · Data updated 2026-11-12
A study at a major hospital will look at whether Long COVID shares biology with chronic fatigue syndrome and what genetic and immune factors may link them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 18, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $348,246 |
| NIH project number | 5R01AI170850-05 |
| Project ID | NIH-11391125 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Long COVID or chronic fatigue syndrome, plus those who may be at risk due to genetic or immune factors, could benefit from future insights.
✕Less likely to help
People without Long COVID or related fatigue symptoms may not directly benefit.
What this research studies
Researchers will use large biobank data and a genetics working group to explore whether Long COVID is a subtype of chronic fatigue syndrome. The project analyzes genetic risk factors, comorbidities, and immune system signals across hundreds of thousands of people. Findings could point to shared mechanisms and potential targets for treatment or risk prediction. The work is centered at Massachusetts General Hospital with collaboration from multiple cohorts and biobanks.
Why it matters
Potential benefit: If successful, the study could clarify disease relationships and guide future diagnostics or personalized care for people with Long COVID or related fatigue syndromes.
How similar studies have gone: Previous research has linked chronic fatigue syndrome with infectious triggers; this study builds on that groundwork using large-scale data.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Saxena, Richa — Massachusetts General Hospital
- Study coordinator: Saxena, Richa
Related research
Other NIH-funded projects on the same topics.
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Is Long COVID a subtype of chronic fatigue syndrome?
This project looks at whether people with Long COVID share the same genetic and immune signs as people with chronic fatigue syndrome by analyzing large collections of patient data.
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Long COVID may be a form of chronic fatigue syndrome
This project looks for shared genetic and immune causes in people with Long COVID and people with chronic fatigue syndrome to explain lingering symptoms.
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Investigating Long COVID as a type of chronic fatigue syndrome
This study is looking into how Long COVID works and what might make some people more likely to experience it, especially since it has symptoms similar to chronic fatigue syndrome, to help find better treatments for those who are struggling with these ongoing issues.
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Human Herpesvirus 6B and ME/CFS: does the virus cause or follow immune problems?
A study to see if HHV-6B reactivation is a cause or result of immune problems in people with ME/CFS, using long-term follow-up and biosamples from patients and controls.
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HHV-6B (a common herpesvirus) and its link to ME/CFS and Long COVID
This project will follow adults with ME/CFS, some with Long COVID, and healthy controls over time to find out whether reactivation of herpesvirus HHV-6B is linked to changes in symptoms and immune responses.
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Investigating T Cell Responses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This study is looking at how a type of immune cell called T cells behaves in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared to healthy individuals, to help uncover clues about the condition and find better ways to treat it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.