Magnetic stimulation treatment for fatigue after stroke
Official title: Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study
Run by VA Office of Research and Development · NCT05584124 · Data updated 2026-11-12
This study is testing whether a type of magnetic treatment can help stroke survivors feel less tired and improve their overall well-being.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 34 Years to 80 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 2 sites (Decatur, Georgia and 1 other locations) |
| Status | Recruiting |
| Started | April 10, 2023 |
| Main results expected | October 29, 2027 |
| Study ends | October 29, 2027 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT05584124 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 35 to 80 who are more than six months post-stroke and experience clinically significant fatigue.
✕Probably not a fit
Patients with contraindications to rTMS, such as certain neurological conditions or severe hypertension, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for individuals experiencing fatigue following a stroke. Fatigue is a prevalent issue that can hinder recovery and quality of life for stroke survivors. Participants will receive either active rTMS or a sham treatment, and their levels of fatigue, mood, and cognitive function will be assessed before and after the intervention. The goal is to determine if rTMS can effectively alleviate post-stroke fatigue and improve overall well-being.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce fatigue in stroke survivors, enhancing their ability to engage in daily activities.
How similar studies have gone: Other studies have shown promising results with rTMS for various neurological conditions, suggesting potential efficacy for post-stroke fatigue.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * More than 6 months post-stroke * Clinically present fatigue Exclusion Criteria: * Contraindications to magnetic resonance imaging (MRI)/transcranial magnetic stimulation (TMS)/repetitive transcranial magnetic stimulation (rTMS), e.g., implanted metal within the head, history of seizures * Inability to follow simple three-step instructions * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe traumatic brain injury (TBI) * Pregnancy * Strokes within stimulation sites * Pregnancy * Severe hypertension (resting systolic blood pressure (SBP) \> 200, DBP \> 120)
Where it's running
-
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States Recruiting -
Ralph H. Johnson VA Medical Center
Charleston, South Carolina, United States Not yet recruiting
Study contacts
- Principal investigator: John H Kindred — Atlanta VA Medical and Rehab Center, Decatur, GA
- Study coordinator: John H Kindred
- Email: John.Kindred1@va.gov
- Phone: (970) 426-9350
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
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Post-stroke fatigue and related clinical factors
We will try to find how common fatigue is and which health and personal factors are linked to it in adults at least three months after their first stroke.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
Nutrition's impact on fatigue after stroke
This study is testing if a nutritional supplement can help stroke survivors feel less tired and improve their overall well-being.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.