Energize-MBC: a web-based fatigue program for women with metastatic breast cancer
Official title: Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11194344 · Data updated 2026-11-12
This project will adapt a cognitive behavioral therapy program delivered online to help women with metastatic breast cancer who have tiring side effects from CDK4/6 inhibitor treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $308,399 |
| NIH project number | 5R34CA289918-02 |
| Project ID | NIH-11194344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women living with metastatic breast cancer who are receiving or recently received a CDK4/6 inhibitor and who are experiencing bothersome fatigue are the intended participants.
✕Less likely to help
People without metastatic breast cancer, not taking CDK4/6 inhibitors, or those who are medically unstable or unable to use telemedicine likely would not benefit or be eligible.
What this research studies
If you join, you would use a web-based version of cognitive behavioral therapy tailored for people living with metastatic breast cancer and treatment-related fatigue. The team will refine the online platform, deliver sessions by telemedicine, and may include wearable activity tracking to monitor daily movement and sleep. The pilot will focus on whether the program is acceptable and workable for participants and will collect early signals about changes in fatigue and daily functioning. Feedback from participants will be used to finalize the program for a larger future trial.
Why it matters
Potential benefit: If successful, the program could reduce treatment-related fatigue and help people feel more able to do daily activities.
How similar studies have gone: Cognitive behavioral therapy for fatigue has shown large benefits in people treated for curable cancers, but it has not been specifically tested in women with metastatic breast cancer on CDK4/6 inhibitors.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Jim, Heather S.l. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Jim, Heather S.l.
Related research
Other NIH-funded projects on the same topics.
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Improving fatigue management for women with metastatic breast cancer
This study is testing a new online therapy program called Energize-MBC designed to help women with metastatic breast cancer who feel tired from their treatment, making it easier for them to feel better and enjoy their daily lives.
-
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This project explores why a type of breast cancer with FGFR1 changes stops responding to hormone therapy and looks for new combination treatments that may help patients live longer.
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Fit2ThriveMB: A digital activity program to help people with metastatic breast cancer feel better and stay active
A digital, at-home physical activity program designed for people with metastatic breast cancer to improve quality of life and daily functioning.
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Acupuncture to ease symptoms for people with metastatic breast cancer
A clinical trial will test whether weekly acupuncture for 12 weeks can reduce symptom burden for people with metastatic breast cancer who are on standard therapy.
-
Predicting end-of-life timing to guide better care for metastatic breast cancer
A clinician-facing project tests a breast cancer prognostic tool in everyday oncology care to help guide conversations and timely hospice referrals for patients nearing the end of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.