Using magnetic stimulation to reduce fatigue in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine if repetitive Transcranial Magnetic Stimulation (rTMS) of the left premotor cortex can alleviate fatigue in patients with Relapsing-Remitting Multiple Sclerosis. Participants will receive either real or sham rTMS for 30 minutes over five consecutive days, followed by assessments through questionnaires and brain scans to evaluate changes in fatigue levels and brain activity. The study seeks to understand the relationship between brain excitation and inhibition in relation to fatigue symptoms in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A confirmed diagnosis of relapse-remitting or secondary progressive multiple sclerosis, according to most recent McDonald's criteria (Thompson et al., 2018). This diagnosis must not be more recent than 3 months
* Must have fatigue as a complaint, and an FSMC score corresponding to at least moderate fatigue (\>53)
* Stable MS medication for at least 3 months

Exclusion Criteria:

* Pregnancy, any subject with the potential to become pregnant must ensure against this (e.g. by taking oral contraceptives, or other high efficacy method)
* MS Relapse or steroid treatment within 3 months prior to inclusion
* Current treatment targeted towards fatigue, or previous if discontinued within 3 months prior to inclusion
* History of neurologic disease or other significant medical conditions, aside from MS
* EDSS \> 6.5
* Major psychiatric disorder, including current clinical depression.
* Intake of medication that primarily acts on CNS or neurotransmission, except SSRI or SNRI
* Pacemaker or other implanted electronic devices
* Any intracranial metal
* Any metallic implant incompatible with MR scanning
* Claustrophobia
* Either patient or their close relatives suffering from epilepsy
* Current Drug or alcohol abuse

Where it's running

• Danish Research Centre for Magnetic Resonance
  Hvidovre, Capital Region, Denmark Recruiting

Study contacts

• Principal investigator: Hartwig R Siebner, MD, DMSc — Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre & University of Copenhagen
• Study coordinator: Hartwig R Siebner, MD, DMSc
• Email: hartwig@drcmr.dk
• Phone: 3862 6541

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.