Effects of nutrient timing on cancer-related fatigue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of time-restricted eating on cancer-related fatigue in patients who have been treated for hematologic neoplasms. Participants will be required to consume all their food within a 10-hour window, which may help regulate their circadian rhythms and alleviate fatigue. The study aims to determine if this dietary approach can improve quality of life for cancer survivors experiencing persistent fatigue. Participants will receive nutrition counseling to support their dietary changes.

Why it matters

Who can join: the full rules

Inclusion criteria (Participants must…):

* Have a diagnosis of a hematologic neoplasm (e.g., leukemia, lymphoma, multiple myeloma);
* Be at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, chimeric antigen receptor (CAR)-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for \>2 months and expected to stay on it until progression is okay);
* Have a baseline level of fatigue, as determined by at least one of the following:

  1. Reporting a score of 4 or higher in response to the question, "What was your worst fatigue in the last week, on a scale of 0-10, where 0 is no fatigue and 10 is the worst fatigue?"
  2. In the habit of taking daytime naps,
  3. Have fatigue that interferes with their ability to work, engage in social events, or is more than would be expected from physical exertion,
* Be able to speak and/or read and write in English or Spanish;
* Be at least 18 years old; and
* Be able to provide informed consent.

Exclusion criteria (participants must not…)

* Be underweight, as defined as a body mass index \<18.5 kg/m2;
* Already eat all their food within a window that is 10 h or shorter most (6/7) days of the week;
* Be employed in a job where they regularly work away from the home at night (e.g., night shift);
* Have surgery planned during the study duration;
* Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., type 1 diabetes, risk for hypoglycemia, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder);
* Be taking insulin; or
* Be on enteral or parenteral nutrition.

Where it's running

• University of Maryland, Baltimore
  Baltimore, Maryland, United States Recruiting

Study contacts

• Study coordinator: Amber Kleckner
• Email: amber.kleckner@umaryland.edu
• Phone: 4107065961

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.