Investigating MitoQ to reduce fatigue in people with Multiple Sclerosis
Official title: MitoQ for Fatigue in Multiple Sclerosis: A Placebo Controlled Trial
Funded at Portland VA Medical Center · NIH-11249112 · Data updated 2026-11-12
This study is looking at whether MitoQ, a special antioxidant, can help reduce fatigue in people with Multiple Sclerosis, as many current treatments don’t work well and can have side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX001955-06 |
| Project ID | NIH-11249112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Multiple Sclerosis and experience significant fatigue.
✕Less likely to help
Patients who do not have Multiple Sclerosis or those who do not experience fatigue as a symptom may not benefit from this research.
What this research studies
This research focuses on evaluating the effects of MitoQ, a mitochondrial-targeted antioxidant, on fatigue experienced by individuals with Multiple Sclerosis (MS). Fatigue is a common and debilitating symptom in MS, and current treatments have limited effectiveness and side effects. The study will involve a placebo-controlled trial where participants will receive either MitoQ or a placebo to assess improvements in fatigue levels. By targeting mitochondrial dysfunction, the research aims to provide a novel approach to managing fatigue in MS patients.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for alleviating fatigue in individuals with Multiple Sclerosis.
How similar studies have gone: Previous studies have shown some success with mitochondrial-targeted therapies like CoQ10, suggesting potential for MitoQ, although this specific approach is novel.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Yadav, Vijayshree — Portland VA Medical Center
- Study coordinator: Yadav, Vijayshree
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.