Condition

Eosinophilic Esophagitis clinical trials and research

• 23Clinical trials
• 34NIH research projects
• 14Countries

Newest Eosinophilic Esophagitis clinical trials

All recruiting trials (23)

• Upadacitinib for Eosinophilic Esophagitis in adults not responding to standard therapy

  This study tests whether upadacitinib, taken with topical corticosteroids, can reduce disease activity in adults with eosinophilic esophagitis who still have symptoms.

  Recruiting Phase 2 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT07588568

• A registry for adults with esophageal movement and reflux problems.

  This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT07506746

• Using a mucosal impedance device to help diagnose chronic esophageal problems

  This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07227506

• Esophageal string test to screen for eosinophilic esophagitis in adults of African descent with swallowing problems

  This study will test whether a 1-hour esophageal string test can detect eosinophilic esophagitis in adults born in Africa (or with African parents) who have trouble swallowing.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 2 other locations · NCT07027826

• Improving management of eosinophilic esophagitis in children and adolescents

  This study is trying to find better ways to manage eosinophilic esophagitis in kids and teens by using simple tests to avoid invasive procedures and improve their quality of life.

  Recruiting at 2 sites Oslo University Hospital · Bergen and 1 other locations · NCT06991881

• How common FIRE is and what it looks like in children with eosinophilic esophagitis

  This project will see how often and in what ways Food Induced Immediate Response of the Esophagus (FIRE) occurs in children aged 6–17 who have eosinophilic esophagitis.

  Recruiting University Hospital, Angers · Angers and 1 other locations · NCT06972147

• Comparing dupilumab and topical corticosteroids for treating eosinophilic esophagitis

  This study is testing whether a new weekly injection called dupilumab works better than a daily swallowed medication for treating eosinophilic esophagitis in young people aged 12 to 25.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT06705387

• Long-term assessment of dupilumab for eosinophilic esophagitis in Germany

  This study is testing how well dupilumab works and how safe it is for people aged 12 and older with eosinophilic esophagitis in Germany over two years.

  Recruiting at 15 sites Sanofi · Aschaffenburg, Bavaria and 14 other locations · NCT06695897

• San Raffaele registry for adults with eosinophilic esophagitis

  This registry will collect clinical, endoscopic, and biopsy information from adults with eosinophilic esophagitis who are referred to the San Raffaele Motility and EoE Unit.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT06443346

• Measuring EDN (a protein from eosinophils) in people with eosinophilic esophagitis

  This will see if measuring EDN in blood, urine, saliva, stool, and esophageal samples can show active disease or remission in people with suspected or known eosinophilic esophagitis who are having an upper GI endoscopy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06387030

• Effect of heated foods on remission in children with Eosinophilic Esophagitis

  This study is testing if giving heated versions of hen's egg and cow's milk can help children with Eosinophilic Esophagitis stay in remission and possibly build tolerance to these foods.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06381219

• Improving maintenance treatment adherence for adults with eosinophilic esophagitis

  This project will test whether extra education plus more frequent follow-up and reminders help adults with eosinophilic esophagitis stick to their long-term medications.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT05730933

• Evaluating EP-104IAR for treating eosinophilic esophagitis in adults

  This study is testing a new treatment called EP-104IAR to see if it can help adults with eosinophilic esophagitis feel better.

  Recruiting at 22 sites Phase 1/2 Eupraxia Pharmaceuticals Inc. · Sydney, New South Wales and 22 other locations · NCT05608681

• Examining the effects of Zemaira in patients with Eosinophilic Esophagitis

  This study is testing if the medication Zemaira can help adults with eosinophilic esophagitis feel better after receiving weekly infusions for four weeks.

  Recruiting at 2 sites Phase 2 Children's Hospital Medical Center, Cincinnati · Bethesda, Maryland and 1 other locations · NCT05485155

• Evaluating gastrointestinal eosinophilic disorders in children

  This study looks at how common eosinophilic gastrointestinal disorders are in children to help improve understanding and treatment of these conditions.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT05219903

• Registry for Eosinophilic Gastrointestinal Disorders

  This study is collecting information from people with Eosinophilic Gastrointestinal Disorders to better understand their symptoms and improve treatments for them.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT05199532

• Testing goat milk protein tolerance in patients with eosinophilic esophagitis triggered by cow milk

  This study is testing if people with eosinophilic esophagitis who can't tolerate cow milk can safely drink goat milk without having a bad reaction.

  Recruiting Shaare Zedek Medical Center · Jerusalem · NCT05180578

• Registry for individuals with food allergies

  This study is collecting health information from people with food allergies to help researchers learn more about the condition and improve treatments.

  Recruiting Food Allergy Research & Education · McLean, Virginia · NCT04653324

• Registry for gastrointestinal motility disorders at Indiana University

  This study is creating a detailed list of patients with gastrointestinal motility disorders to help doctors better understand and treat these conditions.

  Recruiting Indiana University · Indianapolis, Indiana · NCT04506593

• Observing characteristics and inflammatory markers in children with eosinophilic esophagitis

  This study is looking at children with eosinophilic esophagitis to see how their symptoms and lab results relate to inflammation in their bodies.

  Recruiting University of California, San Diego · San Diego, California · NCT03980886

• Exploring esophageal distensibility changes with proton pump inhibitors in eosinophilic esophagitis

  This study is testing how well proton pump inhibitors can improve the flexibility of the esophagus in people with eosinophilic esophagitis.

  Recruiting at 2 sites Indiana University · Indianapolis, Indiana and 1 other locations · NCT03312686

• Evaluating outcomes in eosinophilic gastrointestinal disorders

  This study is trying to find the best ways to measure how well people with eosinophilic gastrointestinal disorders are doing by looking at their symptoms and tissue samples over time.

  Recruiting at 16 sites Children's Hospital Medical Center, Cincinnati · Phoenix, Arizona and 18 other locations · NCT02523118

• Understanding the genetics and natural history of food allergies and related conditions

  This study is trying to understand the causes of food allergies and related conditions by looking at the genetics and health history of people with food allergies, their families, and healthy volunteers over several years.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02504853

NIH-funded research (34)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Esophageal antigen test-guided diet for eosinophilic esophagitis

  A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11445933

• Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts

  This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11443932

• How environmental signals and a receptor may protect or worsen eosinophilic esophagitis

  A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11377324

• Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers

  A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11365332

• Role of protective proteins in the esophagus to treat eosinophilic esophagitis

  A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11353961

• Role of 1q21 Genetic Variants in Eosinophilic Esophagitis

  This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11353128

• Mitochondria and IL-13 in eosinophilic esophagitis

  A study exploring how immune signals and mitochondria interact in eosinophilic esophagitis to find new biomarkers and targets for treatment.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11349699

• Dupilumab versus swallowed fluticasone for narrowing (fibrostenotic) eosinophilic esophagitis

  This trial compares dupilumab injections with swallowed fluticasone in people who have fibrostenotic eosinophilic esophagitis to try to improve esophageal narrowing and swallowing symptoms.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11333745

• How the antibody IgG4 may trigger food-related eosinophilic esophagitis

  This work looks at whether the antibody IgG4 and food proteins stick together in the esophagus and cause inflammation in people with eosinophilic esophagitis.

  NIH research University of Virginia · Charlottesville, United States · NIH-11320742

• How the enzyme GPX3 affects eosinophilic esophagitis

  This work explores whether low levels of the antioxidant enzyme GPX3 make the esophagus more inflamed and scarred in people with eosinophilic esophagitis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11298972

• How immune signals guide allergy-type T cells into the esophagus in eosinophilic esophagitis

  This project looks at whether the GPR15 and C10ORF99 signals cause allergy-type T cells to move into the esophagus in people with eosinophilic esophagitis.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11270648

• How genes and the immune system affect eosinophilic esophagitis

  Researchers are looking at genes and immune responses in people with eosinophilic esophagitis to find biological clues that could lead to better diagnosis and treatments.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11224046

• How environmental factors affect eosinophilic esophagitis

  This research explores how environmental signals influence a protein in our bodies, called AHR, which plays a role in eosinophilic esophagitis, an allergic condition of the esophagus.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11169675

• Improving medication adherence in children with eosinophilic esophagitis

  This study is all about helping teenagers with eosinophilic esophagitis stick to their medication routines better by creating a helpful plan, and it will also look at how a specific medication called dupilumab affects their ability to follow these routines and their overall health.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11168887

• Investigating the role of mitochondria in eosinophilic esophagitis

  This study is looking at how a protein called IL-13 affects the cells in the esophagus of people with eosinophilic esophagitis (EoE), which could help us find new ways to understand and diagnose this condition better.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11164724

• A new tool for diagnosing eosinophilic esophagitis in children

  This study is testing a new tool that uses light to help doctors quickly and accurately diagnose eosinophilic esophagitis (EoE) in kids, making it easier for them to get the right care without needing lots of tissue samples.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11127494

• Investigating how specific T cells move to the esophagus in Eosinophilic Esophagitis

  This study is looking into how certain immune cells move to the esophagus and cause problems for people with Eosinophilic Esophagitis (EoE), with the goal of finding new and easier ways to diagnose and treat this condition.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11116740

• How AHR, OVOL1, and SPINK7 affect eosinophilic esophagitis

  This work looks at how three proteins in the esophagus (AHR, OVOL1, and SPINK7) may protect people who have eosinophilic esophagitis.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11103194

• Comparing two treatments for a type of esophageal disease.

  This study is looking at how well two different treatments work for people with fibrostenotic Eosinophilic Esophagitis, a condition that makes swallowing tough, by comparing a medication called dupilumab with a steroid called fluticasone to see which one helps more.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11103161

• Investigating how certain proteins affect the esophagus in children with eosinophilic esophagitis

  This study is looking at how a part of the esophagus works in kids with eosinophilic esophagitis (EoE) to find out why it sometimes doesn't protect them from allergens, with the hope of discovering new ways to help treat this condition.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11091647

• Understanding how IgG4 affects food allergies in eosinophilic esophagitis.

  This study is looking at how a certain antibody called IgG4 affects eosinophilic esophagitis (EoE), a condition that can be caused by food, to help find better ways to diagnose and treat people with EoE.

  NIH research University of Virginia · Charlottesville, United States · NIH-11072985

• Creating tools to help patients make decisions about eosinophilic esophagitis treatment

  This study is all about helping people with eosinophilic esophagitis (EoE) make better choices about their treatment by creating tools that guide them and their doctors in deciding between medications and diet changes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11060883

• Understanding how immune responses affect the esophagus in children with eosinophilic esophagitis

  This study is looking at how certain immune responses affect the esophagus in kids with eosinophilic esophagitis (EoE), using special lab techniques to help find better ways to understand and treat this condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11059936

• Investigating the causes and factors of eosinophilic esophagitis in veterans

  This study is looking at eosinophilic esophagitis (EoE) in veterans to find out what might be causing it and how it affects their health, so we can better understand and treat this condition.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11043820

• Understanding how GPX3 affects Eosinophilic Esophagitis

  This study is looking at how a protein called GPX3 affects Eosinophilic Esophagitis (EoE), a condition that causes inflammation in the esophagus, to help find new ways to treat it.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11026148

• Investigating early life environmental factors that may cause eosinophilic esophagitis

  This study is looking at how things in a child's early life, like antibiotic use, might affect their chances of developing eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus, by examining samples from baby teeth to find out more about these early exposures.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11006282

• Using advanced technology to understand and treat eosinophilic esophagitis in children.

  This study is looking at how to better understand and treat eosinophilic esophagitis (EoE) in kids by using special imaging technology and computer analysis to spot changes in the esophagus that might be causing the condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10992194

• Understanding how environmental factors influence eosinophilic esophagitis

  This study is looking at how certain things in our environment, like food and air pollution, can affect eosinophilic esophagitis (EoE) and how a specific protein in our body might help protect or worsen this condition, so patients can learn more about how their surroundings impact their health and discover new treatmen

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10938426

• Investigating genetic factors in eosinophilic esophagitis

  This study is looking at how certain rare genetic changes might play a role in eosinophilic esophagitis (EoE) by examining the DNA of families affected by the condition, with the hope of creating tools to help identify people who may be at a higher risk for EoE.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10917389

• A diet tailored to specific allergens for treating eosinophilic esophagitis.

  This study is looking at how a personalized diet can help people with eosinophilic esophagitis (EoE) by figuring out which specific foods trigger their symptoms, so they can avoid those foods without the hassle of a strict elimination diet.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10817001

• Investigating how an enzyme affects esophageal tissue changes in a chronic allergic condition

  This study is looking at how a specific enzyme called lysyl oxidase might affect the worsening of eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus, to help find new ways to treat it and make life easier for people with EoE.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10814141

• Investigating how FOXM1 contributes to eosinophilic esophagitis

  This study is looking at how a protein called FOXM1 might cause problems in the esophagus for people with eosinophilic esophagitis (EoE), which makes it hard to swallow, and aims to find new ways to help improve treatments for this condition.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10724896

• Investigating the role of the esophageal microbiome in children's response to swallowed steroids for eosinophilic esophagitis

  This study is looking at how the germs in the esophagus might affect how well children with eosinophilic esophagitis respond to steroid treatments, with the goal of finding ways to help those who aren't getting better with current therapies.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10558624

• Investigating how early life factors and genetics affect eosinophilic esophagitis

  This study is looking at how things like antibiotic use, how babies are born, and breastfeeding might affect the chances of developing eosinophilic esophagitis (EoE) in people who are more likely to get it because of their genes, and it invites patients to share their early life experiences and genetic information to h

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10441396

Related topics

Quick answers

How many Eosinophilic Esophagitis clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (12 trials), Italy (3 trials), France (2 trials), Netherlands (2 trials), Mali (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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