Improving maintenance treatment adherence for adults with eosinophilic esophagitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators will test whether providing extra education combined with more frequent follow-up visits and patient reminders improves long-term adherence to maintenance medication in adults with eosinophilic esophagitis. Eligible participants are adults with histologically confirmed EoE (>15 eosinophils per high power field) who are on or starting maintenance therapy with a proton pump inhibitor or swallowed topical corticosteroids. The intervention offers additional education, closer monitoring, and reminder prompts while the comparator receives usual care and standard information. Adherence will be tracked over time using medication records and follow-up contacts to determine whether the enhanced support increases persistence with therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent
* Male or female patient
* Age \>18 years
* Previous diagnosis of EoE, confirmed by histopathology, with the presence of \>15 eosinophilic granulocytes per high power field (hpf) in esophageal biopsies
* Current maintenance treatment for EoE with a PPI or swallowed topical corticosteroids or about to start with these maintenance medications as decided during regular clinical practice

Exclusion Criteria:

* Severe and clinically unstable concomitant disease that may interfere with the subject's ability to participate in the study
* Receive investigational treatment during the study
* Dilation of esophagus required
* Insufficient Dutch or English language skills to understand patient information leaflets

Where it's running

• Amsterdam UMC, location AMC
  Amsterdam, Netherlands Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• How common FIRE is and what it looks like in children with eosinophilic esophagitis

  This project will see how often and in what ways Food Induced Immediate Response of the Esophagus (FIRE) occurs in children aged 6–17 who have eosinophilic esophagitis.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.