Using advanced technology to understand and treat eosinophilic esophagitis in children.
Official title: Precision Medicine Approaches for Eosinophilic Esophagitis Using Raman Spectroscopy and Machine Learning
Funded at Vanderbilt University Medical Center · NIH-10992194 · Data updated 2026-11-12
This study is looking at how to better understand and treat eosinophilic esophagitis (EoE) in kids by using special imaging technology and computer analysis to spot changes in the esophagus that might be causing the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | February 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $167,247 |
| NIH project number | 5K23DK131341-04 |
| Project ID | NIH-10992194 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with eosinophilic esophagitis.
✕Less likely to help
Patients who do not have eosinophilic esophagitis or are older than 11 years may not benefit from this research.
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic inflammatory condition affecting the esophagus, particularly in children. The study aims to utilize Raman spectroscopy and machine learning to identify biochemical changes in the esophagus that contribute to EoE. By analyzing these changes, researchers hope to better understand the disease's progression and improve treatment strategies. This approach combines advanced imaging techniques with data analysis to enhance patient care.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children suffering from eosinophilic esophagitis.
How similar studies have gone: Previous research has shown promise in using similar advanced techniques for understanding and treating allergic and inflammatory conditions, indicating potential for success in this approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Hiremath, Girish — Vanderbilt University Medical Center
- Study coordinator: Hiremath, Girish
Related research
Other NIH-funded projects on the same topics.
-
Esophageal antigen test-guided diet for eosinophilic esophagitis
A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.
-
Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
-
How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
-
Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
-
Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.