A diet tailored to specific allergens for treating eosinophilic esophagitis.
Official title: An allergen-specific immune signature-directed diet vs sham diet for treatment of eosinophilic esophagitis: A pilot-feasibility study
Funded at Univ of North Carolina Chapel Hill · NIH-10817001 · Data updated 2026-11-12
This study is looking at how a personalized diet can help people with eosinophilic esophagitis (EoE) by figuring out which specific foods trigger their symptoms, so they can avoid those foods without the hassle of a strict elimination diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | April 30, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $302,088 |
| NIH project number | 5R01DK132001-03 |
| Project ID | NIH-10817001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis who are struggling with dietary management of their condition.
✕Less likely to help
Patients who do not have eosinophilic esophagitis or those whose condition is not related to food allergies may not benefit from this research.
What this research studies
This research investigates a personalized diet based on individual immune responses to allergens in patients with eosinophilic esophagitis (EoE). It aims to replace the current one-size-fits-all dietary elimination approach, which can be burdensome and ineffective. By identifying specific food triggers through advanced testing, the study seeks to streamline dietary management, making it less invasive and more effective for patients. Participants will be monitored to assess the impact of the tailored diet on their symptoms and overall health.
Why it matters
Potential benefit: If successful, this research could lead to more effective dietary treatments for eosinophilic esophagitis, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in using personalized dietary approaches for food allergies, suggesting potential success for this novel method in treating eosinophilic esophagitis.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Dellon, Evan Samuel — Univ of North Carolina Chapel Hill
- Study coordinator: Dellon, Evan Samuel
Related research
Other NIH-funded projects on the same topics.
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Esophageal antigen test-guided diet for eosinophilic esophagitis
A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.
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Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
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How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
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Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
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Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
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Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.