Effect of heated foods on remission in children with Eosinophilic Esophagitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial investigates whether introducing heated food products, specifically hen's egg and cow's milk, can help maintain remission in children with Eosinophilic Esophagitis (EoE). The study involves a controlled food challenge where children will consume heated versions of these allergens, followed by gradual reintroduction of less heated forms. Participants will undergo regular gastroscopies to assess eosinophil levels in biopsies, which will indicate remission status. The goal is to determine if this approach can lead to tolerance induction in affected children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All children (aged 12 months and older) presenting (since 1-1-2014: moment of diagnostic guideline standardization for pedEoE) with diagnosed pedEoE at UZ Leuven eliminating either hen's egg or cow's milk or both and in complete remission after their latest biopsy (no longer than 12 months earlier, but preferentially as short as possible after their latest biopsy) are eligible for the study. If the last biopsy has been performed more than 12 months earlier, a new gastro-duodenoscopy will be performed to verify remission and rule out e.g. active gastritis. If they are on PPI and/or local budesonide treatment, this should be stable for at least 3 months and will remain untouched during the entire study. We will include 18 pedEoE subjects suffering from cow's milk induced EoE and 18 suffering from hen's egg induced EoE.

Exclusion Criteria:

* Children younger than 12 months
* Children with active pedEoE
* Children who refuse to adhere to the protocol
* Children with associated IgE mediated hen's egg and/or cow's milk allergy with specific IgE antibody titers that predict active (baked egg and/or baked milk) food allergy with cut-off titers as used at the consultation of allergy (KLL). Those children will become eligible however if their titers decrease while the study is still open.

Where it's running

• UZ Leuven Gasthuisberg
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Ilse Hoffman, Prof. Dr. — Co-investigator, pediatric gastro-enterology
• Study coordinator: Dominique Bullens, Prof. Dr.
• Email: dominique.bullens@kuleuven.be
• Phone: 0032016343801

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.