Observing characteristics and inflammatory markers in children with eosinophilic esophagitis
Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)
This study is looking at children with eosinophilic esophagitis to see how their symptoms and lab results relate to inflammation in their bodies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 1 Year to 65 Years |
| Sex | All |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (San Diego, California) |
| Trial ID | NCT03980886 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on children diagnosed with eosinophilic esophagitis (EoE) at Rady Children's Hospital. Participants will have their medical information, including symptoms, endoscopy results, and lab findings, collected and entered into a database during routine visits. Blood and biopsy samples will be taken for analysis of inflammatory markers and to create a repository for future studies on disease progression and therapeutic responses. The study aims to enhance understanding of EoE's natural history and the relationship between clinical symptoms and molecular changes.
Who should consider this trial
Good fit: Ideal candidates are children diagnosed with eosinophilic esophagitis who experience symptoms like dysphagia, vomiting, or abdominal pain.
Not a fit: Patients without a diagnosis of eosinophilic esophagitis or those not exhibiting relevant symptoms may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of eosinophilic esophagitis in children.
How similar studies have performed: Other studies have shown success in understanding eosinophilic esophagitis through similar observational approaches, but this specific study adds a novel focus on inflammatory markers.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have a known EoE diagnosis * Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications) * Present with food impaction * Present with esophageal stricture * Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings Exclusion Criteria: * None
Where this trial is running
San Diego, California
- Rady Children's Hospital San Diego — San Diego, California, United States (Recruiting)
Study contacts
- Study coordinator: Kira Chaiboonma, BS
- Email: kchaiboonma@health.ucsd.edu
- Phone: 8589661700
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.