Observing characteristics and inflammatory markers in children with eosinophilic esophagitis
Official title: Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)
Run by University of California, San Diego · NCT03980886 · Data updated 2026-11-12
This study is looking at children with eosinophilic esophagitis to see how their symptoms and lab results relate to inflammation in their bodies.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Year to 65 Years |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (San Diego, California) |
| Status | Recruiting |
| Started | February 11, 2019 |
| Main results expected | December 17, 2028 |
| Study ends | December 17, 2028 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT03980886 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children diagnosed with eosinophilic esophagitis who experience symptoms like dysphagia, vomiting, or abdominal pain.
✕Probably not a fit
Patients without a diagnosis of eosinophilic esophagitis or those not exhibiting relevant symptoms may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on children diagnosed with eosinophilic esophagitis (EoE) at Rady Children's Hospital. Participants will have their medical information, including symptoms, endoscopy results, and lab findings, collected and entered into a database during routine visits. Blood and biopsy samples will be taken for analysis of inflammatory markers and to create a repository for future studies on disease progression and therapeutic responses. The study aims to enhance understanding of EoE's natural history and the relationship between clinical symptoms and molecular changes.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of eosinophilic esophagitis in children.
How similar studies have gone: Other studies have shown success in understanding eosinophilic esophagitis through similar observational approaches, but this specific study adds a novel focus on inflammatory markers.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have a known EoE diagnosis * Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications) * Present with food impaction * Present with esophageal stricture * Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings Exclusion Criteria: * None
Where it's running
-
Rady Children's Hospital San Diego
San Diego, California, United States Recruiting
Study contacts
- Study coordinator: Angie Rodriguez Verdin, BS
- Email: anrodriguezverdin@health.ucsd.edu
- Phone: 8589661700
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Upadacitinib for Eosinophilic Esophagitis in adults not responding to standard therapy
This study tests whether upadacitinib, taken with topical corticosteroids, can reduce disease activity in adults with eosinophilic esophagitis who still have symptoms.
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A registry for adults with esophageal movement and reflux problems.
This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.
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Using a mucosal impedance device to help diagnose chronic esophageal problems
This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.
-
Esophageal string test to screen for eosinophilic esophagitis in adults of African descent with swallowing problems
This study will test whether a 1-hour esophageal string test can detect eosinophilic esophagitis in adults born in Africa (or with African parents) who have trouble swallowing.
-
Improving management of eosinophilic esophagitis in children and adolescents
This study is trying to find better ways to manage eosinophilic esophagitis in kids and teens by using simple tests to avoid invasive procedures and improve their quality of life.
-
How common FIRE is and what it looks like in children with eosinophilic esophagitis
This project will see how often and in what ways Food Induced Immediate Response of the Esophagus (FIRE) occurs in children aged 6–17 who have eosinophilic esophagitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.