Mitochondria and IL-13 in eosinophilic esophagitis

Who could benefit from this research

What this research studies

Eosinophilic esophagitis is a chronic, immune-driven condition that causes ongoing esophageal inflammation. The researchers will focus on how the immune molecule IL-13 changes mitochondria inside esophageal cells and whether these changes drive tissue remodeling and inflammation. They will test molecular pathways (like JAK/STAT signaling) and see if reducing mitochondrial changes can lessen disease features. They also plan to examine mitochondrial alterations as potential biomarkers in patients with EoE. The work combines cell-based studies with analysis that could translate to human patients.

Why it matters

Where this research is happening

• Temple Univ of the Commonwealth
  Philadelphia, United States Active

Researchers

• Principal investigator: Whelan, Kelly a — Temple Univ of the Commonwealth
• Study coordinator: Whelan, Kelly a

Related research

Other NIH-funded projects on the same topics.

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• Role of protective proteins in the esophagus to treat eosinophilic esophagitis

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• Role of 1q21 Genetic Variants in Eosinophilic Esophagitis

  This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.