Understanding how IgG4 affects food allergies in eosinophilic esophagitis.
Defining the Role of Immunoglobulin G4 (IgG4) in Food-Induced Eosinophilic Esophagitis (EoE)
This study is looking at how a certain antibody called IgG4 affects eosinophilic esophagitis (EoE), a condition that can be caused by food, to help find better ways to diagnose and treat people with EoE.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11072985 on NIH RePORTER |
What this research studies
This research investigates the role of a specific antibody, IgG4, in eosinophilic esophagitis (EoE), a condition often triggered by food. The study aims to uncover how IgG4 interacts with food proteins in the esophagus and contributes to inflammation. By analyzing tissue samples and using advanced imaging techniques, researchers hope to identify the mechanisms behind food-induced inflammation in EoE. This could lead to better diagnostic tests and treatments tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis, particularly those who experience food-related symptoms.
Not a fit: Patients who do not have eosinophilic esophagitis or whose symptoms are not related to food allergies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients suffering from eosinophilic esophagitis.
How similar studies have performed: While the role of IgG4 in EoE is being explored, this specific approach to understanding its contribution to food-induced inflammation is relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Mcgowan, Emily Clarke — University of Virginia
- Study coordinator: Mcgowan, Emily Clarke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.