Investigating how an enzyme affects esophageal tissue changes in a chronic allergic condition
Official title: Lysyl oxidase induced esophageal remodeling in eosinophilic esophagitis
Funded at Children's Hosp of Philadelphia · NIH-10814141 · Data updated 2026-11-12
This study is looking at how a specific enzyme called lysyl oxidase might affect the worsening of eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus, to help find new ways to treat it and make life easier for people with EoE.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $380,160 |
| NIH project number | 5R01DK124266-05 |
| Project ID | NIH-10814141 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis who experience chronic symptoms related to esophageal inflammation.
✕Less likely to help
Patients without eosinophilic esophagitis or those with other unrelated esophageal conditions may not benefit from this research.
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic condition that causes inflammation and scarring in the esophagus due to allergic reactions. The study aims to understand the role of lysyl oxidase (LOX), an enzyme that contributes to tissue stiffness and remodeling, in the progression of EoE. By examining how LOX interacts with other cellular signals in the esophagus, the researchers hope to uncover new mechanisms that lead to tissue damage and fibrosis. This could lead to potential new treatments that target these pathways to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse esophageal damage in patients with eosinophilic esophagitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar enzymes in tissue remodeling, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
Related research
Other NIH-funded projects on the same topics.
-
Esophageal antigen test-guided diet for eosinophilic esophagitis
A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.
-
Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
-
How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
-
Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
-
Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.