Investigating how an enzyme affects esophageal tissue changes in a chronic allergic condition
Lysyl oxidase induced esophageal remodeling in eosinophilic esophagitis
This study is looking at how a specific enzyme called lysyl oxidase might affect the worsening of eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus, to help find new ways to treat it and make life easier for people with EoE.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10814141 on NIH RePORTER |
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic condition that causes inflammation and scarring in the esophagus due to allergic reactions. The study aims to understand the role of lysyl oxidase (LOX), an enzyme that contributes to tissue stiffness and remodeling, in the progression of EoE. By examining how LOX interacts with other cellular signals in the esophagus, the researchers hope to uncover new mechanisms that lead to tissue damage and fibrosis. This could lead to potential new treatments that target these pathways to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis who experience chronic symptoms related to esophageal inflammation.
Not a fit: Patients without eosinophilic esophagitis or those with other unrelated esophageal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse esophageal damage in patients with eosinophilic esophagitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar enzymes in tissue remodeling, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.