Using a mucosal impedance device to help diagnose chronic esophageal problems
Diagnostic Utility of Mucosal Impedance Device in Patients With GERD and Chronic Esophageal Disorders:
Medical College of Wisconsin · NCT07227506
This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical College of Wisconsin (other) |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT07227506 on ClinicalTrials.gov |
What this trial studies
This is an observational study that adds MuVI esophageal mucosal impedance measurements to standard upper endoscopy in participants with chronic esophageal symptoms. Measurements from the impedance device will be compared with endoscopic findings, biopsies, and available pH testing to determine diagnostic concordance. Investigators will also examine potential cost implications by considering whether the device could reduce the need for multiple procedures. Exclusion criteria include esophageal stricture, cancer, unstable condition, anticoagulation on the day of procedure, pregnancy, and minors.
Who should consider this trial
Good fit: Adults with chronic typical or atypical reflux symptoms and/or dysphagia who are already scheduled for upper endoscopy and who do not have exclusions such as pregnancy, active esophageal cancer, stricture, or contraindications to the procedure.
Not a fit: Patients with esophageal strictures, active esophageal cancer, unstable medical conditions, minors, pregnant people, or those on anticoagulation at the time of procedure are not eligible and unlikely to benefit from this testing.
Why it matters
Potential benefit: If successful, the device could speed diagnosis and reduce the need for multiple invasive or costly tests.
How similar studies have performed: Prior research on mucosal impedance has shown promising results for distinguishing GERD from eosinophilic esophagitis and detecting mucosal injury, but larger confirmatory and cost-effectiveness studies are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Patients with chronic esophageal symptoms such as atypical or typical reflux symptoms and dysphagia, is here for upper endoscopy testing. Exclusion Criteria: 1. Presence of esophageal stricture 2. Unstable patients who cannot undergo this testing. 3. Patients on anticoagulation on the day of procedure. 4. Presence of esophageal cancer. 5. Pregnancy. 6. Minor patients.
Where this trial is running
Milwaukee, Wisconsin
- Froedtert Hospital — Milwaukee, Wisconsin, United States (RECRUITING)
Study contacts
- Study coordinator: Gokulakrishnan Balasubramanian
- Email: gbalasubramanian@mcw.edu
- Phone: 414-805-3827
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Gerd, Eosinophilic Esophagitis, gerd, eosinophilic esophagitis