Understanding how GPX3 affects Eosinophilic Esophagitis
Official title: Defining the role of GPX3 in Eosinophilic Esophagitis
Funded at Vanderbilt University Medical Center · NIH-11026148 · Data updated 2026-11-12
This study is looking at how a protein called GPX3 affects Eosinophilic Esophagitis (EoE), a condition that causes inflammation in the esophagus, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | March 15, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $650,614 |
| NIH project number | 1R01DK141803-01 |
| Project ID | NIH-11026148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Eosinophilic Esophagitis, particularly children and adults experiencing symptoms.
✕Less likely to help
Patients without Eosinophilic Esophagitis or those with other unrelated esophageal conditions may not benefit from this research.
What this research studies
This research investigates the role of Glutathione Peroxidase 3 (GPX3) in Eosinophilic Esophagitis (EoE), a condition characterized by inflammation and damage to the esophagus. The study focuses on how GPX3 regulates the balance of reactive oxygen species, which are crucial for maintaining healthy esophageal tissue. By examining both human samples and animal models, the research aims to uncover the mechanisms by which GPX3 influences esophageal remodeling and eosinophil recruitment, potentially leading to new therapeutic strategies for EoE.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from Eosinophilic Esophagitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of oxidative stress in EoE, suggesting that this approach could yield significant insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Choksi, Yash — Vanderbilt University Medical Center
- Study coordinator: Choksi, Yash
Related research
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A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
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A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
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A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.