How common FIRE is and what it looks like in children with eosinophilic esophagitis
Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis
This project will see how often and in what ways Food Induced Immediate Response of the Esophagus (FIRE) occurs in children aged 6–17 who have eosinophilic esophagitis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 6 Years to 17 Years |
| Sex | All |
| Sponsor | University Hospital, Angers Government |
| Locations | 2 sites (Angers and 1 other locations) |
| Trial ID | NCT06972147 on ClinicalTrials.gov |
What this trial studies
Researchers will enroll children aged 6–17 who are followed for eosinophilic esophagitis at the allergology unit of Angers University Hospital, with participation from CHU Lille, and collect standardized clinical histories focused on immediate esophageal reactions after eating. Because formal diagnostic criteria for FIRE are not established, investigators will use targeted questionnaires and chart review to distinguish FIRE from oropharyngeal allergy syndromes and from mechanical obstruction related to esophagitis. The study is observational and aims to establish prevalence, describe typical symptoms, and identify associated clinical features in the pediatric population. No experimental treatments or interventions are administered.
Who should consider this trial
Good fit: Children older than 6 and younger than 18 who are followed for eosinophilic esophagitis in the Angers University Hospital allergology unit and can participate in interviews are the intended participants.
Not a fit: Patients outside the 6–17 age range, those not followed at the Angers allergology unit, or those with severe communication or language barriers are unlikely to gain benefit from participating.
Why it matters
Potential benefit: If successful, this work could help clinicians recognize and diagnose FIRE more reliably in children with eosinophilic esophagitis, leading to faster, more appropriate care.
How similar studies have performed: FIRE has been described in case series since 2020 but there are limited systematic epidemiological studies in pediatric eosinophilic esophagitis, so this approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 6 and under 18 years of age at the time of inclusion * Follow-up in the allergology unit of Angers University Hospital for eosinophilic esophagitis Exclusion Criteria: * Patients or legal representative with severe communication or language comprehension difficulties * Patients or legal representatives objecting to study participation
Where this trial is running
Angers and 1 other locations
- HOPPE Anne — Angers, France (Recruiting)
- CHU Lille — Lille, France (Not_yet_recruiting)
Study contacts
- Principal investigator: Anne HOPPE — University Hospital of Angers
- Study coordinator: Anne HOPPE, MD
- Email: anne.hoppe@chu-angers.fr
- Phone: 241353637
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.