Clinical trial Recruiting at 1 site Observational Ages 6 to 17

How common FIRE is and what it looks like in children with eosinophilic esophagitis

Official title: Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis

Run by University Hospital, Angers · NCT06972147 · Data updated 2026-11-12

This project will see how often and in what ways Food Induced Immediate Response of the Esophagus (FIRE) occurs in children aged 6–17 who have eosinophilic esophagitis.

More Eosinophilic Esophagitis trials

Quick facts

Study typeObservational
Ages6 Years to 17 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity Hospital, Angers
Government
Locations2 sites (Angers and 1 other locations)
StatusRecruiting
StartedJuly 1, 2025
Main results expectedAugust 1, 2026
Study endsAugust 1, 2026
Registry record updatedJune 15, 2026
Trial IDNCT06972147 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Children older than 6 and younger than 18 who are followed for eosinophilic esophagitis in the Angers University Hospital allergology unit and can participate in interviews are the intended participants.

Probably not a fit

Patients outside the 6–17 age range, those not followed at the Angers allergology unit, or those with severe communication or language barriers are unlikely to gain benefit from participating.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will enroll children aged 6–17 who are followed for eosinophilic esophagitis at the allergology unit of Angers University Hospital, with participation from CHU Lille, and collect standardized clinical histories focused on immediate esophageal reactions after eating. Because formal diagnostic criteria for FIRE are not established, investigators will use targeted questionnaires and chart review to distinguish FIRE from oropharyngeal allergy syndromes and from mechanical obstruction related to esophagitis. The study is observational and aims to establish prevalence, describe typical symptoms, and identify associated clinical features in the pediatric population. No experimental treatments or interventions are administered.

Why it matters

Potential benefit: If successful, this work could help clinicians recognize and diagnose FIRE more reliably in children with eosinophilic esophagitis, leading to faster, more appropriate care.

How similar studies have gone: FIRE has been described in case series since 2020 but there are limited systematic epidemiological studies in pediatric eosinophilic esophagitis, so this approach is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients over 6 and under 18 years of age at the time of inclusion
* Follow-up in the allergology unit of Angers University Hospital for eosinophilic esophagitis

Exclusion Criteria:

* Patients or legal representative with severe communication or language comprehension difficulties
* Patients or legal representatives objecting to study participation

Where it's running

  • HOPPE Anne
    Angers, France
    Recruiting
  • CHU Lille
    Lille, France
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.